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    CDX2 caudal type homeobox 2 [ Homo sapiens (human) ]

    Gene ID: 1045, updated on 16-Jul-2017
    Official Symbol
    CDX2provided by HGNC
    Official Full Name
    caudal type homeobox 2provided by HGNC
    Primary source
    HGNC:HGNC:1806
    See related
    Ensembl:ENSG00000165556 MIM:600297; Vega:OTTHUMG00000016640
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CDX3; CDX-3; CDX2/AS
    Summary
    This gene is a member of the caudal-related homeobox transcription factor gene family. The encoded protein is a major regulator of intestine-specific genes involved in cell growth an differentiation. This protein also plays a role in early embryonic development of the intestinal tract. Aberrant expression of this gene is associated with intestinal inflammation and tumorigenesis. [provided by RefSeq, Jan 2012]
    Orthologs
    Location:
    13q12.2
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 13 NC_000013.11 (27960918..27969368, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (28536205..28543505, complement)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit pseudogene 2 Neighboring gene long intergenic non-protein coding RNA 543 Neighboring gene uncharacterized LOC105370132 Neighboring gene ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase Neighboring gene RNA, 7SL, cytoplasmic 272, pseudogene

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat downregulates caudal type homeobox 2 in HEK 293T cells PubMed

    Go to the HIV-1, Human Interaction Database

    • Incretin synthesis, secretion, and inactivation, organism-specific biosystem (from REACTOME)
      Incretin synthesis, secretion, and inactivation, organism-specific biosystemIncretins are peptide hormones produced by the gut that enhance the ability of glucose to stimulate insulin secretion from beta cells in the pancreas. Two incretins have been identified: Glucagon-lik...
    • Metabolism of proteins, organism-specific biosystem (from REACTOME)
      Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
    • Peptide hormone metabolism, organism-specific biosystem (from REACTOME)
      Peptide hormone metabolism, organism-specific biosystemPeptide hormones are cleaved from larger precursors in the secretory system (endoplasmic reticulum, Golgi apparatus, secretory granules) of the cell. After secretion peptide hormones are modified and...
    • Preimplantation Embryo, organism-specific biosystem (from WikiPathways)
      Preimplantation Embryo, organism-specific biosystemThe source of this pathway is RNA-Seq data from single-cell pre-implantation embryos (Supplemental Table 1): http://www.nature.com/nsmb/journal/v20/n9/full/nsmb.2660.html Analysis options for runnin...
    • Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1), organism-specific biosystem (from REACTOME)
      Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1), organism-specific biosystemIn L cells of the intestine the transcription factors TCF-4 (TCF7L2) and Beta-catenin form a heterodimer and bind the G2 enhancer of the Proglucagon gene GCG,activating its transcription to yield Pro...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    animal organ morphogenesis TAS
    Traceable Author Statement
    more info
    PubMed 
    anterior/posterior axis specification IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    blood vessel development IEA
    Inferred from Electronic Annotation
    more info
     
    cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    endosome to lysosome transport IEA
    Inferred from Electronic Annotation
    more info
     
    establishment or maintenance of epithelial cell apical/basal polarity IEA
    Inferred from Electronic Annotation
    more info
     
    intestinal epithelial cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    labyrinthine layer development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of somitogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    somatic stem cell population maintenance IEA
    Inferred from Electronic Annotation
    more info
     
    transcription from RNA polymerase II promoter TAS
    Traceable Author Statement
    more info
    PubMed 
    trophectodermal cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    condensed nuclear chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    protein complex IEA
    Inferred from Electronic Annotation
    more info
     
    transcriptional repressor complex IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    homeobox protein CDX-2
    Names
    caudal type homeo box transcription factor 2
    caudal type homeobox transcription factor 2
    caudal-type homeobox protein 2
    homeobox protein miniCDX2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001265.4NP_001256.3  homeobox protein CDX-2

      See identical proteins and their annotated locations for NP_001256.3

      Status: REVIEWED

      Source sequence(s)
      AL591024, BC014461, BI085425
      Consensus CDS
      CCDS9328.1
      UniProtKB/Swiss-Prot
      Q99626
      Related
      ENSP00000370408.6, OTTHUMP00000018176, ENST00000381020.7, OTTHUMT00000044312
      Conserved Domains (2) summary
      pfam00046
      Location:190242
      Homeobox; Homeobox domain
      pfam04731
      Location:13171
      Caudal_act; Caudal like protein activation region

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p7 Primary Assembly

      Range
      27960918..27969368 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011534875.2XP_011533177.1  homeobox protein CDX-2 isoform X1

      Conserved Domains (2) summary
      pfam00046
      Location:198250
      Homeobox; Homeobox domain
      pfam04731
      Location:13171
      Caudal_act; Caudal like protein activation region
    2. XM_011534878.2XP_011533180.1  homeobox protein CDX-2 isoform X4

      Conserved Domains (1) summary
      pfam00046
      Location:81133
      Homeobox; Homeobox domain
    3. XM_011534879.2XP_011533181.1  homeobox protein CDX-2 isoform X5

      Conserved Domains (1) summary
      pfam00046
      Location:73125
      Homeobox; Homeobox domain
    4. XM_011534877.2XP_011533179.1  homeobox protein CDX-2 isoform X3

      See identical proteins and their annotated locations for XP_011533179.1

      Conserved Domains (2) summary
      pfam00046
      Location:190228
      Homeobox; Homeobox domain
      pfam04731
      Location:13171
      Caudal_act; Caudal like protein activation region
    5. XM_011534876.2XP_011533178.1  homeobox protein CDX-2 isoform X2

      Conserved Domains (2) summary
      pfam00046
      Location:198236
      Homeobox; Homeobox domain
      pfam04731
      Location:13171
      Caudal_act; Caudal like protein activation region

    Alternate CHM1_1.1

    Genomic

    1. NC_018924.2 Alternate CHM1_1.1

      Range
      28504663..28511974 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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