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    Palld palladin, cytoskeletal associated protein [ Mus musculus (house mouse) ]

    Gene ID: 72333, updated on 5-Nov-2017
    Official Symbol
    Palldprovided by MGI
    Official Full Name
    palladin, cytoskeletal associated proteinprovided by MGI
    Primary source
    MGI:MGI:1919583
    See related
    Ensembl:ENSMUSG00000058056 Vega:OTTMUSG00000031055
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    6030492A02; 2410003B16Rik
    Expression
    Broad expression in bladder adult (RPKM 40.1), ovary adult (RPKM 20.2) and 21 other tissues See more
    Orthologs
    Location:
    8; 8 B3.1
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 8 NC_000074.6 (61511429..61902700, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (63993818..64381487, complement)

    Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene SH3 domain containing ring finger 1 Neighboring gene uncharacterized LOC102638389 Neighboring gene carbonyl reductase 4 Neighboring gene predicted gene, 35254 Neighboring gene lysyl-tRNA synthetase pseudogene Neighboring gene RIKEN cDNA 4930512H18 gene Neighboring gene DEAD (Asp-Glu-Ala-Asp) box polypeptide 60

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC150248

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    cytoskeletal protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    epithelial cell morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    keratinocyte development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of podosome assembly ISO
    Inferred from Sequence Orthology
    more info
     
    ruffle organization ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    actin filament ISO
    Inferred from Sequence Orthology
    more info
     
    actin filament ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    axon ISO
    Inferred from Sequence Orthology
    more info
     
    axonal growth cone ISO
    Inferred from Sequence Orthology
    more info
     
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    filopodium ISO
    Inferred from Sequence Orthology
    more info
     
    focal adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    podosome ISO
    Inferred from Sequence Orthology
    more info
     
    ruffle ISO
    Inferred from Sequence Orthology
    more info
     
    stress fiber ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    palladin
    Names
    90kDa actin-associated protein palladin
    palladin isoform

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081390.1NP_001074859.1  palladin isoform 4

      See identical proteins and their annotated locations for NP_001074859.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks two alternate in-frame exons and differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (4) lacks two alternate internal segments and has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC121881, AC139846, AC147616
      Consensus CDS
      CCDS40350.1
      UniProtKB/Swiss-Prot
      Q9ET54
      Related
      ENSMUSP00000034057.7, ENSMUST00000034057.13
      Conserved Domains (3) summary
      cd00096
      Location:465542
      Ig; Immunoglobulin domain
      cd05893
      Location:10341108
      Ig_Palladin_C; C-terminal immunoglobulin (Ig)-like domain of palladin
      pfam07679
      Location:278368
      I-set; Immunoglobulin I-set domain
    2. NM_001293772.1NP_001280701.1  palladin isoform 1

      See identical proteins and their annotated locations for NP_001280701.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC121881, AK031696, AK052489, BB658601
      Consensus CDS
      CCDS80882.1
      UniProtKB/Swiss-Prot
      Q9ET54
      Related
      ENSMUSP00000112442.1, OTTMUSP00000040564, ENSMUST00000121785.8, OTTMUST00000076933
      Conserved Domains (3) summary
      cd00096
      Location:465542
      Ig; Immunoglobulin domain
      cd05893
      Location:12761350
      Ig_Palladin_C; C-terminal immunoglobulin (Ig)-like domain of palladin
      pfam07679
      Location:278368
      I-set; Immunoglobulin I-set domain
    3. NM_001293773.1NP_001280702.1  palladin isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform 1.
      Source sequence(s)
      AC121881, AK076423, AK087270, JX477684
      Consensus CDS
      CCDS80881.1
      UniProtKB/TrEMBL
      K0BWC3
      Related
      ENSMUSP00000113874.1, OTTMUSP00000040566, ENSMUST00000121493.8, OTTMUST00000076936
      Conserved Domains (3) summary
      cd00096
      Location:76153
      Ig; Immunoglobulin domain
      cd05893
      Location:870944
      Ig_Palladin_C; C-terminal immunoglobulin (Ig)-like domain of palladin
      pfam07679
      Location:754844
      I-set; Immunoglobulin I-set domain
    4. NM_001293774.1NP_001280703.1  palladin isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (3) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform 1.
      Source sequence(s)
      AC121881, AK149663, BY766661
      Consensus CDS
      CCDS80880.1
      UniProtKB/Swiss-Prot
      Q9ET54
      Related
      ENSMUSP00000112374.1, OTTMUSP00000040565, ENSMUST00000121200.8, OTTMUST00000076935
      Conserved Domains (3) summary
      cd00096
      Location:298367
      Ig; Immunoglobulin domain
      cd05893
      Location:531605
      Ig_Palladin_C; C-terminal immunoglobulin (Ig)-like domain of palladin
      pfam07679
      Location:415505
      I-set; Immunoglobulin I-set domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000074.6 Reference GRCm38.p4 C57BL/6J

      Range
      61511429..61902700 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006509507.3XP_006509570.1  palladin isoform X4

      See identical proteins and their annotated locations for XP_006509570.1

      Conserved Domains (3) summary
      cd00096
      Location:315384
      Ig; Immunoglobulin domain
      cd05893
      Location:548622
      Ig_Palladin_C; C-terminal immunoglobulin (Ig)-like domain of palladin
      pfam07679
      Location:432522
      I-set; Immunoglobulin I-set domain
    2. XM_006509508.3XP_006509571.1  palladin isoform X4

      See identical proteins and their annotated locations for XP_006509571.1

      Conserved Domains (3) summary
      cd00096
      Location:315384
      Ig; Immunoglobulin domain
      cd05893
      Location:548622
      Ig_Palladin_C; C-terminal immunoglobulin (Ig)-like domain of palladin
      pfam07679
      Location:432522
      I-set; Immunoglobulin I-set domain
    3. XM_011242242.2XP_011240544.1  palladin isoform X1

      See identical proteins and their annotated locations for XP_011240544.1

      UniProtKB/Swiss-Prot
      Q9ET54
      Conserved Domains (3) summary
      cd00096
      Location:465542
      Ig; Immunoglobulin domain
      cd05893
      Location:12761350
      Ig_Palladin_C; C-terminal immunoglobulin (Ig)-like domain of palladin
      pfam07679
      Location:278368
      I-set; Immunoglobulin I-set domain
    4. XM_006509503.2XP_006509566.1  palladin isoform X2

      UniProtKB/Swiss-Prot
      Q9ET54
      Conserved Domains (3) summary
      cd00096
      Location:465542
      Ig; Immunoglobulin domain
      cd05893
      Location:12591333
      Ig_Palladin_C; C-terminal immunoglobulin (Ig)-like domain of palladin
      pfam07679
      Location:278368
      I-set; Immunoglobulin I-set domain
    5. XM_006509504.3XP_006509567.1  palladin isoform X3

      See identical proteins and their annotated locations for XP_006509567.1

      Conserved Domains (3) summary
      cd00096
      Location:76153
      Ig; Immunoglobulin domain
      cd05893
      Location:887961
      Ig_Palladin_C; C-terminal immunoglobulin (Ig)-like domain of palladin
      pfam07679
      Location:771861
      I-set; Immunoglobulin I-set domain
    6. XM_006509505.3XP_006509568.1  palladin isoform X3

      See identical proteins and their annotated locations for XP_006509568.1

      Conserved Domains (3) summary
      cd00096
      Location:76153
      Ig; Immunoglobulin domain
      cd05893
      Location:887961
      Ig_Palladin_C; C-terminal immunoglobulin (Ig)-like domain of palladin
      pfam07679
      Location:771861
      I-set; Immunoglobulin I-set domain
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