Send to:

Choose Destination

Links from PubMed

    • Showing Current items.

    ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide [ Homo sapiens (human) ]

    Gene ID: 124, updated on 19-May-2018
    Official Symbol
    ADH1Aprovided by HGNC
    Official Full Name
    alcohol dehydrogenase 1A (class I), alpha polypeptideprovided by HGNC
    Primary source
    See related
    Ensembl:ENSG00000187758 MIM:103700; Vega:OTTHUMG00000131026
    Gene type
    protein coding
    RefSeq status
    Homo sapiens
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    This gene encodes a member of the alcohol dehydrogenase family. The encoded protein is the alpha subunit of class I alcohol dehydrogenase, which consists of several homo- and heterodimers of alpha, beta and gamma subunits. Alcohol dehydrogenases catalyze the oxidation of alcohols to aldehydes. This gene is active in the liver in early fetal life but only weakly active in adult liver. This gene is found in a cluster with six additional alcohol dehydrogenase genes, including those encoding the beta and gamma subunits, on the long arm of chromosome 4. Mutations in this gene may contribute to variation in certain personality traits and substance dependence. [provided by RefSeq, Nov 2010]
    Biased expression in liver (RPKM 735.3) and fat (RPKM 36.3) See more
    See ADH1A in Genome Data Viewer
    Exon count:
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 4 NC_000004.12 (99276366..99291028, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (100197523..100212185, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100507053 Neighboring gene proliferating cell nuclear antigen pseudogene 2 Neighboring gene ADH6 promoter Neighboring gene alcohol dehydrogenase 6 (class V) Neighboring gene ADH1A promoter Neighboring gene ADH1B promoter Neighboring gene alcohol dehydrogenase 1B (class I), beta polypeptide Neighboring gene ADH1C promoter region Neighboring gene alcohol dehydrogenase 1C (class I), gamma polypeptide

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Extended genetic effects of ADH cluster genes on the risk of alcohol dependence: from GWAS to replication.
    NHGRI GWA Catalog
    Products Interactant Other Gene Complex Source Pubs Description



    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    alcohol dehydrogenase (NAD) activity TAS
    Traceable Author Statement
    more info
    alcohol dehydrogenase activity, zinc-dependent EXP
    Inferred from Experiment
    more info
    alcohol dehydrogenase activity, zinc-dependent IDA
    Inferred from Direct Assay
    more info
    protein binding IPI
    Inferred from Physical Interaction
    more info
    retinol dehydrogenase activity TAS
    Traceable Author Statement
    more info
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    Process Evidence Code Pubs
    alcohol metabolic process NAS
    Non-traceable Author Statement
    more info
    drug metabolic process TAS
    Traceable Author Statement
    more info
    ethanol oxidation TAS
    Traceable Author Statement
    more info
    Component Evidence Code Pubs
    cytosol IDA
    Inferred from Direct Assay
    more info
    cytosol TAS
    Traceable Author Statement
    more info
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    Preferred Names
    alcohol dehydrogenase 1A
    ADH, alpha subunit
    alcohol dehydrogenase 1 (class I), alpha polypeptide
    alcohol dehydrogenase subunit alpha
    aldehyde reductase

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_000667.3NP_000658.1  alcohol dehydrogenase 1A

      See identical proteins and their annotated locations for NP_000658.1

      Status: REVIEWED

      Source sequence(s)
      AK290558, BG199182, CB116632
      Consensus CDS
      ENSP00000209668.2, OTTHUMP00000161653, ENST00000209668.2, OTTHUMT00000253669
      Conserved Domains (1) summary
      alcohol_DH_class_I_II_IV; class I, II, IV alcohol dehydrogenases

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly


    1. NC_000004.12 Reference GRCh38.p12 Primary Assembly

      99276366..99291028 complement
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center