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    Abi1 abl-interactor 1 [ Mus musculus (house mouse) ]

    Gene ID: 11308, updated on 22-Apr-2017
    Official Symbol
    Abi1provided by MGI
    Official Full Name
    abl-interactor 1provided by MGI
    Primary source
    MGI:MGI:104913
    See related
    Ensembl:ENSMUSG00000058835 Vega:OTTMUSG00000016621
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    E3B1; NAP1; abi-1; Ssh3bp1
    Orthologs
    Location:
    2 A3; 2 15.18 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (22939989..23040241, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (22795509..22895760, complement)

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein Neighboring gene prenyl (solanesyl) diphosphate synthase, subunit 1 Neighboring gene ribosomal protein L17 pseudogene Neighboring gene acyl-Coenzyme A binding domain containing 5 Neighboring gene microtubule associated serine/threonine kinase-like Neighboring gene YME1-like 1 (S. cerevisiae)

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC6064

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    SH3 domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    cadherin binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein tyrosine kinase activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    actin polymerization or depolymerization IEA
    Inferred from Electronic Annotation
    more info
     
    dendrite morphogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lamellipodium morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    megakaryocyte development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    movement of cell or subcellular component ISO
    Inferred from Sequence Orthology
    more info
     
    peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    somitogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    SCAR complex ISO
    Inferred from Sequence Orthology
    more info
     
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    cell leading edge IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    filopodium ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    lamellipodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lamellipodium ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    neuron projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    synapse IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    abl interactor 1
    Names
    abelson interactor 1
    ablphilin-1
    eps8 SH3 domain-binding protein
    eps8 binding protein
    spectrin SH3 domain binding protein 1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077190.3NP_001070658.1  abl interactor 1 isoform 1

      See identical proteins and their annotated locations for NP_001070658.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest protein (isoform 1).
      Source sequence(s)
      AK034476, AK164040, BP767858, BY278454
      Consensus CDS
      CCDS38061.1
      UniProtKB/Swiss-Prot
      Q8CBW3
      UniProtKB/TrEMBL
      Q3TPY5
      Related
      ENSMUSP00000118491.1, OTTMUSP00000044764, ENSMUST00000123948.7, OTTMUST00000083345
      Conserved Domains (2) summary
      cd11971
      Location:423481
      SH3_Abi1; Src homology 3 domain of Abl Interactor 1
      pfam07815
      Location:93169
      Abi_HHR; Abl-interactor HHR
    2. NM_001077192.3NP_001070660.1  abl interactor 1 isoform 4

      See identical proteins and their annotated locations for NP_001070660.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks two alternate in-frame exons and uses an alternate in-frame splice site compared to variant 1. The resulting protein (isoform 4) is shorter compared to isoform 1.
      Source sequence(s)
      AK164040, AY033645, BP767858, BY278454
      Consensus CDS
      CCDS38060.1
      UniProtKB/Swiss-Prot
      Q8CBW3
      UniProtKB/TrEMBL
      Q3TPY5
      Related
      ENSMUSP00000120621.1, OTTMUSP00000044747, ENSMUST00000149719.7, OTTMUST00000083324
      Conserved Domains (2) summary
      pfam07815
      Location:93164
      Abi_HHR; Abl-interactor HHR
      cl17036
      Location:388446
      SH3; Src Homology 3 domain superfamily
    3. NM_001077193.3NP_001070661.1  abl interactor 1 isoform 5

      See identical proteins and their annotated locations for NP_001070661.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks three alternate in-frame exons compared to variant 1. The resulting protein (isoform 5) is shorter compared to isoform 1.
      Source sequence(s)
      AK152061, AK164040, BP767858, BY278454
      Consensus CDS
      CCDS38058.1
      UniProtKB/Swiss-Prot
      Q8CBW3
      UniProtKB/TrEMBL
      Q3TPY5
      Related
      ENSMUSP00000110191.3, OTTMUSP00000044766, ENSMUST00000114544.9, OTTMUST00000083347
      Conserved Domains (2) summary
      pfam07815
      Location:93164
      Abi_HHR; Abl-interactor HHR
      cl17036
      Location:330388
      SH3; Src Homology 3 domain superfamily
    4. NM_001331043.1NP_001317972.1  abl interactor 1 isoform 6

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) uses an alternate in-frame splice site in the central coding region, compared to variant 1. The resulting protein (isoform 6) is one amino acid shorter than isoform 1.
      Source sequence(s)
      AK164040, BP767858, BY278454, CJ135811, EL607233
      Consensus CDS
      CCDS84480.1
      UniProtKB/TrEMBL
      B7ZCU0, Q3TPY5
    5. NM_001331044.1NP_001317973.1  abl interactor 1 isoform 7

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) lacks an alternate in-frame exon in the central coding region, compared to variant 1. The resulting protein (isoform 7) is shorter compared to isoform 1.
      Source sequence(s)
      AK152046, AK164040, BP767858, BY278454, CJ135811
      Consensus CDS
      CCDS84481.1
      UniProtKB/TrEMBL
      B7ZCU3, Q3TPY5
    6. NM_001331045.1NP_001317974.1  abl interactor 1 isoform 8

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) uses an alternate in-frame splice site and lacks an alternate in-frame exon in the central coding region, compared to variant 1. The resulting protein (isoform 8) is shorter compared to isoform 1.
      Source sequence(s)
      AK152046, AK164040, BP767858, BY278454, CJ135811, CX212013
      Consensus CDS
      CCDS84479.1
      UniProtKB/TrEMBL
      B7ZCU4, Q3TPY5
    7. NM_007380.4NP_031406.2  abl interactor 1 isoform 3

      See identical proteins and their annotated locations for NP_031406.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region and uses an alternate in-frame splice site compared to variant 1. The resulting protein (isoform 3) is shorter compared to isoform 1.
      Source sequence(s)
      AK164040, AK167328, BP767858, BY278454
      Consensus CDS
      CCDS50513.1
      UniProtKB/Swiss-Prot
      Q8CBW3
      UniProtKB/TrEMBL
      Q3TJR5, Q3TPY5
      Related
      ENSMUSP00000120462.1, OTTMUSP00000044749, ENSMUST00000140164.7, OTTMUST00000040201
      Conserved Domains (2) summary
      cd11971
      Location:417475
      SH3_Abi1; Src homology 3 domain of Abl Interactor 1
      pfam07815
      Location:93164
      Abi_HHR; Abl-interactor HHR
    8. NM_145994.3NP_666106.1  abl interactor 1 isoform 2

      See identical proteins and their annotated locations for NP_666106.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. The resulting protein (isoform 2) is shorter compared to isoform 1.
      Source sequence(s)
      AK164040, AK167568, BP767858, BY278454
      Consensus CDS
      CCDS38059.1
      UniProtKB/TrEMBL
      Q3TJ64, Q3TPY5
      Related
      ENSMUSP00000117335.1, OTTMUSP00000044748, ENSMUST00000126112.7, OTTMUST00000083325
      Conserved Domains (2) summary
      cd11971
      Location:418476
      SH3_Abi1; Src homology 3 domain of Abl Interactor 1
      pfam07815
      Location:93164
      Abi_HHR; Abl-interactor HHR

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

      Range
      22939989..23040241 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006497620.2XP_006497683.1  abl interactor 1 isoform X4

      Related
      ENSMUSP00000090860.6, OTTMUSP00000044769, ENSMUST00000093171.12, OTTMUST00000083351
      Conserved Domains (2) summary
      pfam07815
      Location:93169
      Abi_HHR; Abl-interactor HHR
      cl17036
      Location:393451
      SH3; Src Homology 3 domain superfamily
    2. XM_006497617.2XP_006497680.1  abl interactor 1 isoform X1

      Related
      ENSMUSP00000088957.6, OTTMUSP00000044765, ENSMUST00000091394.12, OTTMUST00000083346
      Conserved Domains (2) summary
      cd11971
      Location:422480
      SH3_Abi1; Src homology 3 domain of Abl Interactor 1
      pfam07815
      Location:93169
      Abi_HHR; Abl-interactor HHR
    3. XM_006497618.2XP_006497681.1  abl interactor 1 isoform X2

      Related
      ENSMUSP00000077997.7, OTTMUSP00000044768, ENSMUST00000078977.13, OTTMUST00000083350
      Conserved Domains (2) summary
      pfam07815
      Location:93169
      Abi_HHR; Abl-interactor HHR
      cl17036
      Location:394452
      SH3; Src Homology 3 domain superfamily
    4. XM_006497619.1XP_006497682.1  abl interactor 1 isoform X3

      See identical proteins and their annotated locations for XP_006497682.1

      UniProtKB/TrEMBL
      B7ZCU2
      Related
      ENSMUSP00000120769.1, OTTMUSP00000044767, ENSMUST00000153931.7, OTTMUST00000083348
      Conserved Domains (2) summary
      pfam07815
      Location:93169
      Abi_HHR; Abl-interactor HHR
      cl17036
      Location:335393
      SH3; Src Homology 3 domain superfamily
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