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    UGT2B17 UDP glucuronosyltransferase family 2 member B17 [ Homo sapiens (human) ]

    Gene ID: 7367, updated on 16-Jan-2017
    Official Symbol
    UGT2B17provided by HGNC
    Official Full Name
    UDP glucuronosyltransferase family 2 member B17provided by HGNC
    Primary source
    HGNC:HGNC:12547
    See related
    Ensembl:ENSG00000197888 MIM:601903; Vega:OTTHUMG00000129305
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BMND12; UDPGT2B17
    Summary
    This gene encodes a member of the uridine diphosphoglucuronosyltransferase protein family. The encoded enzyme catalyzes the transfer of glucuronic acid from uridine diphosphoglucuronic acid to a diverse array of substrates including steroid hormones and lipid-soluble drugs. This process, known as glucuronidation, is an intermediate step in the metabolism of steroids. Copy number variation in this gene is associated with susceptibility to osteoporosis.[provided by RefSeq, Apr 2010]
    Orthologs
    Location:
    4q13.2
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 4 NC_000004.12 (68537184..68568527, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (69402902..69434245, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene transmembrane protease, serine 11E Neighboring gene UDP glucuronosyltransferase family 2 member B29, pseudogene Neighboring gene RAS guanyl releasing protein 2 (calcium and DAG-regulated) pseudogene Neighboring gene UBX domain protein 2A pseudogene

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    glucuronosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT retinoic acid binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    cellular glucuronidation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    flavonoid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    flavonoid glucuronidation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    steroid metabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    organelle membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    UDP-glucuronosyltransferase 2B17
    Names
    C19-steroid-specific UDP-glucuronosyltransferase
    C19-steroid-specific UDPGT
    UDP glucuronosyltransferase 2 family, polypeptide B17
    UDP glycosyltransferase 2 family, member B17
    UDP-glucuronyltransferase, family 2, beta-17
    NP_001068.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_017033.1 RefSeqGene

      Range
      5001..36344
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001077.3NP_001068.1  UDP-glucuronosyltransferase 2B17 precursor

      See identical proteins and their annotated locations for NP_001068.1

      Status: REVIEWED

      Source sequence(s)
      AC147055, U59209
      Consensus CDS
      CCDS3523.1
      UniProtKB/Swiss-Prot
      O75795
      Related
      ENSP00000320401, OTTHUMP00000159641, ENST00000317746, OTTHUMT00000251436
      Conserved Domains (2) summary
      PHA03392
      Location:6508
      egt; ecdysteroid UDP-glucosyltransferase; Provisional
      pfam00201
      Location:24518
      UDPGT; UDP-glucoronosyl and UDP-glucosyl transferase

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p7 Primary Assembly

      Range
      68537184..68568527 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018915.2 Alternate CHM1_1.1

      Range
      69439588..69470934 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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