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    CRP C-reactive protein [ Homo sapiens (human) ]

    Gene ID: 1401, updated on 25-Sep-2016
    Official Symbol
    CRPprovided by HGNC
    Official Full Name
    C-reactive proteinprovided by HGNC
    Primary source
    HGNC:HGNC:2367
    See related
    Ensembl:ENSG00000132693 HPRD:00422; MIM:123260; Vega:OTTHUMG00000035344
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PTX1
    Summary
    The protein encoded by this gene belongs to the pentaxin family. It is involved in several host defense related functions based on its ability to recognize foreign pathogens and damaged cells of the host and to initiate their elimination by interacting with humoral and cellular effector systems in the blood. Consequently, the level of this protein in plasma increases greatly during acute phase response to tissue injury, infection, or other inflammatory stimuli. [provided by RefSeq, Sep 2009]
    Orthologs
    Location:
    1q23.2
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 1 NC_000001.11 (159712289..159714623, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (159682079..159684396, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 10 subfamily J member 6 pseudogene Neighboring gene C-reactive protein pseudogene 1 Neighboring gene ribosomal protein L27 pseudogene 2 Neighboring gene uncharacterized LOC101928264

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    A genome-wide association scan on the levels of markers of inflammation in Sardinians reveals associations that underpin its complex regulation.
    NHGRI GWA Catalog
    A genome-wide association study identifies protein quantitative trait loci (pQTLs).
    NHGRI GWA Catalog
    Are C-reactive protein associated genetic variants associated with serum levels and retinal markers of microvascular pathology in Asian populations from Singapore?
    NHGRI GWA Catalog
    C-reactive protein (CRP) promoter polymorphisms influence circulating CRP levels in a genome-wide association study of African Americans.
    NHGRI GWA Catalog
    Common Variants in the CRP Promoter are Associated with a High C-Reactive Protein Level in Kawasaki Disease.
    NHGRI GWA Catalog
    Genetic Loci associated with C-reactive protein levels and risk of coronary heart disease.
    NHGRI GWA Catalog
    Genome-wide association analysis of metabolic traits in a birth cohort from a founder population.
    NHGRI GWA Catalog
    Genome-wide association and population genetic analysis of C-reactive protein in African American and Hispanic American women.
    NHGRI GWA Catalog
    Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1.
    NHGRI GWA Catalog
    Genome-wide association study for C-reactive protein levels identified pleiotropic associations in the IL6 locus.
    NHGRI GWA Catalog
    Genome-wide association with C-reactive protein levels in CLHNS: evidence for the CRP and HNF1A loci and their interaction with exposure to a pathogenic environment.
    NHGRI GWA Catalog
    Genome-wide association with select biomarker traits in the Framingham Heart Study.
    NHGRI GWA Catalog
    Loci related to metabolic-syndrome pathways including LEPR,HNF1A, IL6R, and GCKR associate with plasma C-reactive protein: the Women's Genome Health Study.
    NHGRI GWA Catalog
    Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels.
    NHGRI GWA Catalog
    New variants including ARG1 polymorphisms associated with C-reactive protein levels identified by genome-wide association and pathway analysis.
    NHGRI GWA Catalog
    Polymorphisms of the HNF1A gene encoding hepatocyte nuclear factor-1 alpha are associated with C-reactive protein.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat The dimeric pentamers of CRP are stabilized by two zinc ions trapped within a cleft of the effector face of CRP in the presence of HIV-1 Tat protein PubMed

    Go to the HIV-1, Human Interaction Database

    • Classical antibody-mediated complement activation, organism-specific biosystem (from REACTOME)
      Classical antibody-mediated complement activation, organism-specific biosystemC1, the first component of complement is a complex containing three protein species, C1q, C1r, and C1s. C1q is assembled from six identical subunits each of which consists of three homologous chains ...
    • Complement cascade, organism-specific biosystem (from REACTOME)
      Complement cascade, organism-specific biosystemIn the complement cascade, a panel of soluble molecules rapidly and effectively senses a danger or damage and triggers reactions to provide a response that discriminates among foreign intruders, cell...
    • Creation of C4 and C2 activators, organism-specific biosystem (from REACTOME)
      Creation of C4 and C2 activators, organism-specific biosystemTwo pathways lead to a complex capable of activating C4 and C2.The classical pathway is triggered by activation of the C1-complex, which consists of hexameric molecule C1q and a tetramer comprising t...
    • IL6-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
      IL6-mediated signaling events, organism-specific biosystem
      IL6-mediated signaling events
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Initial triggering of complement, organism-specific biosystem (from REACTOME)
      Initial triggering of complement, organism-specific biosystemComplement activation is due to a cascade of proteolytic steps, performed by serine protease domains in some of the components. Three different pathways of activation are distinguished triggered by t...
    • Innate Immune System, organism-specific biosystem (from REACTOME)
      Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
    • Selenium Pathway, organism-specific biosystem (from WikiPathways)
      Selenium Pathway, organism-specific biosystem
      Selenium Pathway
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC88244, MGC149895

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    calcium ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    choline binding TAS
    Traceable Author Statement
    more info
    PubMed 
    complement component C1q binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    low-density lipoprotein particle binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    low-density lipoprotein particle receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    NOT virion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular region NAS
    Non-traceable Author Statement
    more info
    PubMed 
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    C-reactive protein
    Names
    C-reactive protein, pentraxin-related
    pentraxin 1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_013007.1 RefSeqGene

      Range
      5001..7301
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000567.2NP_000558.2  C-reactive protein isoform 1 precursor

      See identical proteins and their annotated locations for NP_000558.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) retains an intron in the 3' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AI609949, BG533281, BG618967, X56214, X56692
      Consensus CDS
      CCDS30911.1
      UniProtKB/Swiss-Prot
      P02741
      Related
      ENSP00000255030, OTTHUMP00000033307, ENST00000255030, OTTHUMT00000085553
      Conserved Domains (1) summary
      pfam00354
      Location:25220
      Pentaxin; Pentaxin family
    2. NM_001329057.1NP_001315986.1  C-reactive protein isoform 1 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript. Both variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AI609949, AK289443, BC070257, BG618397
      Consensus CDS
      CCDS30911.1
      Conserved Domains (1) summary
      pfam00354
      Location:25220
      Pentaxin; Pentaxin family
    3. NM_001329058.1NP_001315987.1  C-reactive protein isoform 2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains an alternate internal intron compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AI609949, AL445528, BC020766
      Conserved Domains (1) summary
      cl22861
      Location:1966
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p7 Primary Assembly

      Range
      159712289..159714623 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011509207.2XP_011507509.1  

      UniProtKB/Swiss-Prot
      P02741
      Conserved Domains (1) summary
      pfam00354
      Location:25220
      Pentaxin; Pentaxin family

    Alternate CHM1_1.1

    Genomic

    1. NC_018912.2 Alternate CHM1_1.1

      Range
      161076594..161078894 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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