Format

Send to:

Choose Destination

Links from PubMed

    • Showing Current items.

    TNNI3 troponin I3, cardiac type [ Canis lupus familiaris (dog) ]

    Gene ID: 403566, updated on 8-Sep-2017
    Official Symbol
    TNNI3provided by VGNC
    Official Full Name
    troponin I3, cardiac typeprovided by VGNC
    See related
    Ensembl:ENSCAFG00000002618
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    Location:
    chromosome: 1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    105 current CanFam3.1 (GCF_000002285.3) 1 NC_006583.3 (102475146..102478319)

    Chromosome 1 - NC_006583.3Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L26-like Neighboring gene dynein axonemal assembly factor 3 Neighboring gene troponin T1, slow skeletal type Neighboring gene protein phosphatase 1 regulatory subunit 12C Neighboring gene EPS8 like 1

    Genomic Sequence:
    NC_006583.3 Chromosome 1 Reference CanFam3.1 Primary Assembly

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Adrenergic signaling in cardiomyocytes, organism-specific biosystem (from KEGG)
      Adrenergic signaling in cardiomyocytes, organism-specific biosystemCardiac myocytes express at least six subtypes of adrenergic receptor (AR) which include three subtypes of beta-AR (beta-1, beta-2, beta-3) and three subtypes of the alpha-1-AR (alpha-1A, alpha-1B, a...
    • Adrenergic signaling in cardiomyocytes, conserved biosystem (from KEGG)
      Adrenergic signaling in cardiomyocytes, conserved biosystemCardiac myocytes express at least six subtypes of adrenergic receptor (AR) which include three subtypes of beta-AR (beta-1, beta-2, beta-3) and three subtypes of the alpha-1-AR (alpha-1A, alpha-1B, a...
    • Cardiac conduction, organism-specific biosystem (from REACTOME)
      Cardiac conduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Cardiac muscle contraction, organism-specific biosystem (from KEGG)
      Cardiac muscle contraction, organism-specific biosystemContraction of the heart is a complex process initiated by the electrical excitation of cardiac myocytes (excitation-contraction coupling, ECC). In cardiac myocytes, Ca2+ influx induced by activation...
    • Cardiac muscle contraction, conserved biosystem (from KEGG)
      Cardiac muscle contraction, conserved biosystemContraction of the heart is a complex process initiated by the electrical excitation of cardiac myocytes (excitation-contraction coupling, ECC). In cardiac myocytes, Ca2+ influx induced by activation...
    • Dilated cardiomyopathy, organism-specific biosystem (from KEGG)
      Dilated cardiomyopathy, organism-specific biosystemDilated cardiomyopathy (DCM) is a heart muscle disease characterised by dilation and impaired contraction of the left or both ventricles that results in progressive heart failure and sudden cardiac d...
    • Dilated cardiomyopathy, conserved biosystem (from KEGG)
      Dilated cardiomyopathy, conserved biosystemDilated cardiomyopathy (DCM) is a heart muscle disease characterised by dilation and impaired contraction of the left or both ventricles that results in progressive heart failure and sudden cardiac d...
    • Hypertrophic cardiomyopathy (HCM), organism-specific biosystem (from KEGG)
      Hypertrophic cardiomyopathy (HCM), organism-specific biosystemHypertrophic cardiomyopathy (HCM) is a primary myocardial disorder with an autosomal dominant pattern of inheritance that is characterized by hypertrophy of the left ventricles with histological feat...
    • Hypertrophic cardiomyopathy (HCM), conserved biosystem (from KEGG)
      Hypertrophic cardiomyopathy (HCM), conserved biosystemHypertrophic cardiomyopathy (HCM) is a primary myocardial disorder with an autosomal dominant pattern of inheritance that is characterized by hypertrophy of the left ventricles with histological feat...
    • Ion homeostasis, organism-specific biosystem (from REACTOME)
      Ion homeostasis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Muscle contraction, organism-specific biosystem (from REACTOME)
      Muscle contraction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Striated Muscle Contraction, organism-specific biosystem (from REACTOME)
      Striated Muscle Contraction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • cAMP signaling pathway, organism-specific biosystem (from KEGG)
      cAMP signaling pathway, organism-specific biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...
    • cAMP signaling pathway, conserved biosystem (from KEGG)
      cAMP signaling pathway, conserved biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...

    Markers

    Homology

    Gene Ontology Provided by GO

    Function Evidence Code Pubs
    actin filament binding IEA
    Inferred from Electronic Annotation
    more info
     
    calcium channel inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
     
    calcium-dependent protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein domain specific binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    troponin C binding IEA
    Inferred from Electronic Annotation
    more info
     
    troponin T binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cardiac muscle contraction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cellular calcium ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of ATPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of cardiac muscle contraction by calcium ion signaling IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of systemic arterial blood pressure by ischemic conditions IEA
    Inferred from Electronic Annotation
    more info
     
    skeletal muscle contraction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    vasculogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    ventricular cardiac muscle tissue morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cardiac Troponin complex IEA
    Inferred from Electronic Annotation
    more info
     
    cardiac myofibril IEA
    Inferred from Electronic Annotation
    more info
     
    troponin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Preferred Names
    troponin I, cardiac muscle
    Names
    cardiac troponin I

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003041.1NP_001003041.1  troponin I, cardiac muscle

      See identical proteins and their annotated locations for NP_001003041.1

      Status: PROVISIONAL

      Source sequence(s)
      AF506750
      UniProtKB/Swiss-Prot
      Q8MKD5
      Related
      ENSCAFP00000003805.2, ENSCAFT00000004116.2
      Conserved Domains (2) summary
      pfam11636
      Location:1932
      Troponin-I_N; Troponin I residues 1-32
      pfam00992
      Location:47178
      Troponin; Troponin

    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 105 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference CanFam3.1 Primary Assembly

    Genomic

    1. NC_006583.3 Reference CanFam3.1 Primary Assembly

      Range
      102475146..102478319
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center