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    CD33 CD33 molecule [ Homo sapiens (human) ]

    Gene ID: 945, updated on 5-Nov-2017
    Official Symbol
    CD33provided by HGNC
    Official Full Name
    CD33 moleculeprovided by HGNC
    Primary source
    HGNC:HGNC:1659
    See related
    Ensembl:ENSG00000105383 MIM:159590; Vega:OTTHUMG00000182891
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    p67; SIGLEC3; SIGLEC-3
    Orthologs
    Location:
    19q13.41
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 19 NC_000019.10 (51211054..51240019)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (51728335..51743274)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene sialic acid binding Ig like lectin 21, pseudogene Neighboring gene microRNA 8074 Neighboring gene sialic acid binding Ig like lectin 22, pseudogene Neighboring gene uncharacterized LOC107985327 Neighboring gene SIGLEC family like 1 Neighboring gene long intergenic non-protein coding RNA 1872 Neighboring gene sialic acid binding Ig like lectin 24, pseudogene

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.
    NHGRI GWA Catalog
    Genome-wide association analysis reveals putative Alzheimer's disease susceptibility loci in addition to APOE.
    NHGRI GWA Catalog
    Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat upregulates CD33 in HEK 293T cells PubMed
    Vpr vpr HIV-1 Vpr downregulates CD33 expression in PBMC PubMed

    Go to the HIV-1, Human Interaction Database

    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
    • Hematopoietic cell lineage, organism-specific biosystem (from KEGG)
      Hematopoietic cell lineage, organism-specific biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
    • Hematopoietic cell lineage, conserved biosystem (from KEGG)
      Hematopoietic cell lineage, conserved biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystem (from REACTOME)
      Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystemA number of receptors and cell adhesion molecules play a key role in modifying the response of cells of lymphoid origin (such as B-, T- and NK cells) to self and tumor antigens, as well as to pathoge...
    • Innate Immune System, organism-specific biosystem (from REACTOME)
      Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
    • Neutrophil degranulation, organism-specific biosystem (from REACTOME)
      Neutrophil degranulation, organism-specific biosystemNeutrophils are the most abundant leukocytes (white blood cells), indispensable in defending the body against invading microorganisms. In response to infection, neutrophils leave the circulation and ...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Clone Names

    • FLJ00391

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    cell-cell signaling TAS
    Traceable Author Statement
    more info
    PubMed 
    negative regulation of cell proliferation TAS
    Traceable Author Statement
    more info
    PubMed 
    neutrophil degranulation TAS
    Traceable Author Statement
    more info
     
    regulation of immune response TAS
    Traceable Author Statement
    more info
     
    signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
     
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    specific granule membrane TAS
    Traceable Author Statement
    more info
     
    tertiary granule membrane TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    myeloid cell surface antigen CD33
    Names
    CD33 antigen (gp67)
    CD33 molecule transcript
    gp67
    sialic acid-binding Ig-like lectin 3

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001082618.1NP_001076087.1  myeloid cell surface antigen CD33 isoform 2

      See identical proteins and their annotated locations for NP_001076087.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in a shorter protein (isoform 2, also known as CD33m), compared to isoform 1.
      Source sequence(s)
      AW007749, AY162464, BP303860
      Consensus CDS
      CCDS46157.1
      UniProtKB/Swiss-Prot
      P20138
      Related
      ENSP00000410126.1, OTTHUMP00000270424, ENST00000421133.6, OTTHUMT00000464200
      Conserved Domains (1) summary
      pfam00047
      Location:19100
      ig; Immunoglobulin domain
    2. NM_001177608.1NP_001171079.1  myeloid cell surface antigen CD33 isoform 3 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AK304810, AK309558, BP295158
      Consensus CDS
      CCDS54299.1
      UniProtKB/Swiss-Prot
      P20138
      Related
      ENSP00000375673.2, OTTHUMP00000270422, ENST00000391796.7, OTTHUMT00000464198
      Conserved Domains (3) summary
      smart00410
      Location:26128
      IG_like; Immunoglobulin like
      pfam00047
      Location:146227
      ig; Immunoglobulin domain
      cl11960
      Location:23139
      Ig; Immunoglobulin domain
    3. NM_001772.3NP_001763.3  myeloid cell surface antigen CD33 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001763.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1), also known as CD33M.
      Source sequence(s)
      AW007749, BC028152, BP303860
      Consensus CDS
      CCDS33084.1
      UniProtKB/Swiss-Prot
      P20138
      UniProtKB/TrEMBL
      Q546G0
      Related
      ENSP00000262262.3, OTTHUMP00000270423, ENST00000262262.4, OTTHUMT00000464199
      Conserved Domains (3) summary
      smart00410
      Location:26128
      IG_like; Immunoglobulin like
      pfam00047
      Location:146227
      ig; Immunoglobulin domain
      cl11960
      Location:23139
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p7 Primary Assembly

      Range
      51211054..51240019
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017027508.1XP_016882997.1  myeloid cell surface antigen CD33 isoform X1

      Conserved Domains (3) summary
      smart00410
      Location:80182
      IG_like; Immunoglobulin like
      pfam00047
      Location:200281
      ig; Immunoglobulin domain
      cl11960
      Location:77193
      Ig; Immunoglobulin domain
    2. XM_017027509.1XP_016882998.1  myeloid cell surface antigen CD33 isoform X2

    3. XM_017027510.1XP_016882999.1  myeloid cell surface antigen CD33 isoform X4

    4. XM_011527532.2XP_011525834.1  myeloid cell surface antigen CD33 isoform X3

      See identical proteins and their annotated locations for XP_011525834.1

      UniProtKB/Swiss-Prot
      P20138
      UniProtKB/TrEMBL
      Q546G0
      Conserved Domains (3) summary
      smart00410
      Location:26128
      IG_like; Immunoglobulin like
      pfam00047
      Location:146227
      ig; Immunoglobulin domain
      cl11960
      Location:23139
      Ig; Immunoglobulin domain
    5. XM_011527531.2XP_011525833.1  myeloid cell surface antigen CD33 isoform X1

      Conserved Domains (3) summary
      smart00410
      Location:80182
      IG_like; Immunoglobulin like
      pfam00047
      Location:200281
      ig; Immunoglobulin domain
      cl11960
      Location:77193
      Ig; Immunoglobulin domain

    Alternate CHM1_1.1

    Genomic

    1. NC_018930.2 Alternate CHM1_1.1

      Range
      51730399..51745342
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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