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    STE5 Ste5p [ Saccharomyces cerevisiae S288c ]

    Gene ID: 851680, updated on 9-Apr-2017
    Gene symbol
    STE5
    Gene description
    Ste5p
    Primary source
    SGD:S000002510
    Locus tag
    YDR103W
    Gene type
    protein coding
    RNA name
    Ste5p
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288c (strain: S288c)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    HMD3; NUL3
    See STE5 in Map Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (658350..661103)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene putative hydrolase Neighboring gene hypothetical protein Neighboring gene Spo71p Neighboring gene Tms1p

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • MAPK Signaling Pathway, organism-specific biosystem (from WikiPathways)
      MAPK Signaling Pathway, organism-specific biosystemThe MAPK/ERK pathway is a signal transduction pathway that couples intracellular responses to the binding of growth factors to cell surface receptors. In many cell types, activation of this pathway p...
    • MAPK signaling pathway - yeast, organism-specific biosystem (from KEGG)
      MAPK signaling pathway - yeast, organism-specific biosystemThe S. cerevisiae genome encodes multiple MAP kinase orthologs. One (Fus3) mediates cellular response to peptide pheromones. Another (Kss1) permits adjustment to nutrient limiting conditions. A third...
    • MAPK signaling pathway - yeast, conserved biosystem (from KEGG)
      MAPK signaling pathway - yeast, conserved biosystemThe S. cerevisiae genome encodes multiple MAP kinase orthologs. One (Fus3) mediates cellular response to peptide pheromones. Another (Kss1) permits adjustment to nutrient limiting conditions. A third...
    Products Interactant Other Gene Complex Source Pubs Description

    Homology

    Gene Ontology Provided by GO

    Function Evidence Code Pubs
    MAP-kinase scaffold activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatidylinositol-4,5-bisphosphate binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    mating projection tip IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Names
    Ste5p
    NP_010388.1
    • Pheromone-responsive MAPK scaffold protein; couples activation of the G-protein-coupled pheromone receptor to MAPK activation; intramolecular interaction of PH and VWA domains blocks activation of assembled signaling cascade components (Ste11p, Ste7p and Fus3p) under basal conditions; Gbeta-gamma (Ste4p-Ste18p)-dependent docking at the plasma membrane and binding of PI(4,5)P2 by the PH domain relieves autoinhibition, resulting in pheromone-dependent pathway activation

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      658350..661103
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180411.1NP_010388.1  TPA: Ste5p [Saccharomyces cerevisiae S288c]

      See identical proteins and their annotated locations for NP_010388.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P32917
      Conserved Domains (2) summary
      pfam11610
      Location:287316
      Ste5; Scaffold protein Ste5-Fus5 binding region
      pfam12194
      Location:594775
      Ste5_C; Protein kinase Fus3-binding
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