Format

Send to:

Choose Destination

Links from PubMed

    • Showing Current items.

    SLC29A4 solute carrier family 29 member 4 [ Homo sapiens (human) ]

    Gene ID: 222962, updated on 10-Sep-2016
    Official Symbol
    SLC29A4provided by HGNC
    Official Full Name
    solute carrier family 29 member 4provided by HGNC
    Primary source
    HGNC:HGNC:23097
    See related
    Ensembl:ENSG00000164638 HPRD:15362; MIM:609149; Vega:OTTHUMG00000023797
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ENT4; PMAT
    Summary
    This gene encodes a member of the SLC29A/ENT transporter protein family. The encoded membrane protein catalyzes the reuptake of monoamines into presynaptic neurons, thus determining the intensity and duration of monoamine neural signaling. It has been shown to transport several compounds, including serotonin, dopamine, and the neurotoxin 1-methyl-4-phenylpyridinium. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
    Orthologs
    Location:
    7p22.1
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 7 NC_000007.14 (5274311..5304073)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (5322561..5343704)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 215, pseudogene Neighboring gene WD repeat domain, phosphoinositide interacting 2 Neighboring gene trinucleotide repeat containing 18 Neighboring gene uncharacterized LOC100129484

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Markers

    Homology

    Clone Names

    • FLJ34923

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    monoamine transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoside transmembrane transporter activity TAS
    Traceable Author Statement
    more info
     
    Process Evidence Code Pubs
    monoamine transport IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoside transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    equilibrative nucleoside transporter 4
    Names
    plasma membrane monoamine transporter
    solute carrier family 29 (equilibrative nucleoside transporter), member 4
    solute carrier family 29 (nucleoside transporters), member 4

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001040661.1NP_001035751.1  equilibrative nucleoside transporter 4 isoform 1

      See identical proteins and their annotated locations for NP_001035751.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Variants 1 and 2 encode the same isoform.
      Source sequence(s)
      AC093376, AY485959, BC047592, H07897
      Consensus CDS
      CCDS5340.1
      UniProtKB/Swiss-Prot
      Q7RTT9
      Related
      ENSP00000297195, OTTHUMP00000200583, ENST00000297195, OTTHUMT00000323998
      Conserved Domains (1) summary
      cl15430
      Location:75503
      Nucleoside_tran; Nucleoside transporter
    2. NM_001300847.1NP_001287776.1  equilibrative nucleoside transporter 4 isoform 2

      See identical proteins and their annotated locations for NP_001287776.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and uses two alternate splice sites in the central coding region, which results in an internal frameshifted section, compared to variant 1. The encoded isoform (2) is shorter and has a distinct internal segment, compared to isoform 1.
      Source sequence(s)
      AK092242, AY485959, BC025325, BU740709, H07897
      Consensus CDS
      CCDS75561.1
      UniProtKB/Swiss-Prot
      Q7RTT9
      Related
      ENSP00000385845, OTTHUMP00000200584, ENST00000406453, OTTHUMT00000323999
      Conserved Domains (1) summary
      cl15430
      Location:75489
      Nucleoside_tran; Nucleoside transporter
    3. NM_153247.2NP_694979.2  equilibrative nucleoside transporter 4 isoform 1

      See identical proteins and their annotated locations for NP_694979.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AY485959, BC047592, BM069878, BU740709, H07897
      Consensus CDS
      CCDS5340.1
      UniProtKB/Swiss-Prot
      Q7RTT9
      Related
      ENSP00000380081, OTTHUMP00000025415, ENST00000396872, OTTHUMT00000060118
      Conserved Domains (1) summary
      cl15430
      Location:75503
      Nucleoside_tran; Nucleoside transporter

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p7 Primary Assembly

      Range
      5274311..5304073
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011515200.2XP_011513502.1  

      See identical proteins and their annotated locations for XP_011513502.1

      UniProtKB/Swiss-Prot
      Q7RTT9
      Conserved Domains (1) summary
      cl15430
      Location:75503
      Nucleoside_tran; Nucleoside transporter
    2. XM_011515201.2XP_011513503.1  

      See identical proteins and their annotated locations for XP_011513503.1

      UniProtKB/Swiss-Prot
      Q7RTT9
      Conserved Domains (1) summary
      cl15430
      Location:75503
      Nucleoside_tran; Nucleoside transporter
    3. XM_006715667.3XP_006715730.1  

      See identical proteins and their annotated locations for XP_006715730.1

      UniProtKB/Swiss-Prot
      Q7RTT9
      Conserved Domains (1) summary
      cl15430
      Location:75503
      Nucleoside_tran; Nucleoside transporter
    4. XM_006715668.2XP_006715731.1  

      Conserved Domains (1) summary
      cl15430
      Location:2311
      Nucleoside_tran; Nucleoside transporter
    5. XM_005249658.4XP_005249715.1  

      See identical proteins and their annotated locations for XP_005249715.1

      UniProtKB/Swiss-Prot
      Q7RTT9
      Conserved Domains (1) summary
      cl15430
      Location:75489
      Nucleoside_tran; Nucleoside transporter

    Alternate CHM1_1.1

    Genomic

    1. NC_018918.2 Alternate CHM1_1.1

      Range
      5322266..5343242
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center