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    HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) [ Homo sapiens (human) ]

    Gene ID: 3183, updated on 3-Sep-2017
    Official Symbol
    HNRNPCprovided by HGNC
    Official Full Name
    heterogeneous nuclear ribonucleoprotein C (C1/C2)provided by HGNC
    Primary source
    HGNC:HGNC:5035
    See related
    Ensembl:ENSG00000092199 MIM:164020; Vega:OTTHUMG00000170757
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C1; C2; HNRNP; HNRPC; SNRPC
    Summary
    This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene can act as a tetramer and is involved in the assembly of 40S hnRNP particles. Multiple transcript variants encoding at least two different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    14q11.2
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 14 NC_000014.9 (21209136..21269479, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (21677295..21737638, complement)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene myoneurin pseudogene Neighboring gene long intergenic non-protein coding RNA 641 Neighboring gene RPGR interacting protein 1 Neighboring gene mitochondrial ribosomal protein S17 pseudogene 6 Neighboring gene SPT16 homolog, facilitates chromatin remodeling subunit Neighboring gene uncharacterized LOC107984643

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Genome-wide association of bipolar disorder suggests an enrichment of replicable associations in regions near genes.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify heterogeneous nuclear ribonucleoprotein C (HNRNPC), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify heterogeneous nuclear ribonucleoprotein C (HNRNPC), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Nef nef Tandem affinity purification and mass spectrometry analysis identify heterogeneous nuclear ribonucleoprotein C (HNRNPC), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify heterogeneous nuclear ribonucleoprotein C (HNRNPC), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Rev rev HIV-1 Rev interacting protein, heterogeneous nuclear ribonucleoprotein C (HNRNPC), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with HNRNPC is increased by RRE PubMed

    Go to the HIV-1, Human Interaction Database

    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
    • Metabolism of proteins, organism-specific biosystem (from REACTOME)
      Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
    • Post-translational protein modification, organism-specific biosystem (from REACTOME)
      Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
    • Processing of Capped Intron-Containing Pre-mRNA, organism-specific biosystem (from REACTOME)
      Processing of Capped Intron-Containing Pre-mRNA, organism-specific biosystemCo-transcriptional pre-mRNA splicing is not obligatory. Pre-mRNA splicing begins co-transcriptionally and often continues post-transcriptionally. Human genes contain an average of nine introns per ge...
    • Regulation of Telomerase, organism-specific biosystem (from Pathway Interaction Database)
      Regulation of Telomerase, organism-specific biosystem
      Regulation of Telomerase
    • SUMO E3 ligases SUMOylate target proteins, organism-specific biosystem (from REACTOME)
      SUMO E3 ligases SUMOylate target proteins, organism-specific biosystemSUMO proteins are conjugated to lysine residues of target proteins via an isopeptide bond with the C-terminal glycine of SUMO (reviewed in Zhao 2007, Gareau and Lima 2010, Hannoun et al. 2010, Citro ...
    • SUMOylation, organism-specific biosystem (from REACTOME)
      SUMOylation, organism-specific biosystemSmall Ubiquitin-like MOdifiers (SUMOs) are a family of 3 proteins (SUMO1,2,3) that are reversibly conjugated to lysine residues of target proteins via a glycine-lysine isopeptide bond (reviewed in Ha...
    • SUMOylation of RNA binding proteins, organism-specific biosystem (from REACTOME)
      SUMOylation of RNA binding proteins, organism-specific biosystemSUMOylation of RNA-binding proteins (Li et al. 2004, reviewed in Filosa et al. 2013) alters their interactions with nucleic acids and with proteins. Whereas SUMOylation of HNRNPC decreases its affini...
    • Spliceosome, organism-specific biosystem (from KEGG)
      Spliceosome, organism-specific biosystemAfter transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, th...
    • Spliceosome, conserved biosystem (from KEGG)
      Spliceosome, conserved biosystemAfter transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, th...
    • mRNA Processing, organism-specific biosystem (from WikiPathways)
      mRNA Processing, organism-specific biosystemThis process describes the conversion of precursor messenger RNA into mature messenger RNA (mRNA). The pre-mRNA molecule undergoes three main modifications. These modifications are 5' capping, 3' po...
    • mRNA Splicing, organism-specific biosystem (from REACTOME)
      mRNA Splicing, organism-specific biosystemThe process in which excision of introns from the primary transcript of messenger RNA (mRNA) is followed by ligation of the two exon termini exposed by removal of each intron, is called mRNA splicing...
    • mRNA Splicing - Major Pathway, organism-specific biosystem (from REACTOME)
      mRNA Splicing - Major Pathway, organism-specific biosystemThe splicing of pre-mRNA occurs within a large, very dynamic complex, designated the 'spliceosome'. The 50-60S spliceosomes are estimated to be 40-60 nm in diameter, and have molecular weights in the...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC104306, MGC105117, MGC117353, MGC131677

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    N6-methyladenosine-containing RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    RNA binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA polymerase II distal enhancer sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    mRNA 3'-UTR binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleosomal DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    poly(U) RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    telomerase RNA binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    3'-UTR-mediated mRNA stabilization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ATP-dependent chromatin remodeling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA metabolic process TAS
    Traceable Author Statement
    more info
     
    RNA splicing TAS
    Traceable Author Statement
    more info
    PubMed 
    mRNA splicing, via spliceosome IC
    Inferred by Curator
    more info
    PubMed 
    mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mRNA splicing, via spliceosome TAS
    Traceable Author Statement
    more info
     
    negative regulation of telomere maintenance via telomerase IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    osteoblast differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    catalytic step 2 spliceosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    spliceosomal complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with telomerase holoenzyme complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    heterogeneous nuclear ribonucleoproteins C1/C2
    Names
    hnRNP C1/C2
    nuclear ribonucleoprotein particle C1 protein
    nuclear ribonucleoprotein particle C2 protein

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029011.1 RefSeqGene

      Range
      5001..65344
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001077442.1NP_001070910.1  heterogeneous nuclear ribonucleoproteins C1/C2 isoform a

      See identical proteins and their annotated locations for NP_001070910.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1 and 3 both encode isoform a, also known as isoform C2.
      Source sequence(s)
      AB209527, AL135744, BC108658, DB449514
      Consensus CDS
      CCDS41915.1
      UniProtKB/Swiss-Prot
      P07910
      Related
      ENSP00000452276.1, OTTHUMP00000244328, ENST00000557201.5, OTTHUMT00000410235
      Conserved Domains (1) summary
      cd12603
      Location:1585
      RRM_hnRNPC; RNA recognition motif in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)
    2. NM_001077443.1NP_001070911.1  heterogeneous nuclear ribonucleoproteins C1/C2 isoform b

      See identical proteins and their annotated locations for NP_001070911.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and lacks an in-frame segment compared to variant 1. The resulting isoform (b, also known as isoform C1) has the same N- and C-termini but is shorter compared to isoform a. Variants 2 and 4 both encode isoform b.
      Source sequence(s)
      AL135744, BC108658, DB449514
      Consensus CDS
      CCDS45079.1
      UniProtKB/Swiss-Prot
      P07910
      Related
      ENSP00000338095.6, OTTHUMP00000244316, ENST00000336053.10, OTTHUMT00000410220
      Conserved Domains (1) summary
      cd12603
      Location:1585
      RRM_hnRNPC; RNA recognition motif in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)
    3. NM_004500.3NP_004491.2  heterogeneous nuclear ribonucleoproteins C1/C2 isoform b

      See identical proteins and their annotated locations for NP_004491.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame segment compared to variant 1. The resulting isoform (b, also known as isoform C1) has the same N- and C-termini but is shorter compared to isoform a. Variants 2 and 4 both encode isoform b.
      Source sequence(s)
      AL135744, BC003394, DB449514
      Consensus CDS
      CCDS45079.1
      UniProtKB/Swiss-Prot
      P07910
      Related
      ENSP00000450544.1, OTTHUMP00000244329, ENST00000553300.5, OTTHUMT00000410236
      Conserved Domains (1) summary
      cd12603
      Location:1585
      RRM_hnRNPC; RNA recognition motif in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)
    4. NM_031314.2NP_112604.2  heterogeneous nuclear ribonucleoproteins C1/C2 isoform a

      See identical proteins and their annotated locations for NP_112604.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a, also known as isoform C2). Variants 1 and 3 both encode isoform a.
      Source sequence(s)
      AB209527, AL135744, DB449514
      Consensus CDS
      CCDS41915.1
      UniProtKB/Swiss-Prot
      P07910
      Related
      ENSP00000451291.1, OTTHUMP00000244319, ENST00000554455.5, OTTHUMT00000410225
      Conserved Domains (1) summary
      cd12603
      Location:1585
      RRM_hnRNPC; RNA recognition motif in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p7 Primary Assembly

      Range
      21209136..21269479 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011536709.2XP_011535011.1  heterogeneous nuclear ribonucleoproteins C1/C2 isoform X1

      See identical proteins and their annotated locations for XP_011535011.1

      UniProtKB/Swiss-Prot
      P07910
      Related
      ENSP00000404848.2, OTTHUMP00000244331, ENST00000420743.6, OTTHUMT00000410240
      Conserved Domains (1) summary
      cd12603
      Location:1585
      RRM_hnRNPC; RNA recognition motif in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)
    2. XM_017021253.1XP_016876742.1  heterogeneous nuclear ribonucleoproteins C1/C2 isoform X2

      UniProtKB/Swiss-Prot
      P07910
      Related
      ENSP00000450725.1, OTTHUMP00000244317, ENST00000554969.5, OTTHUMT00000410222
      Conserved Domains (1) summary
      cd12603
      Location:1585
      RRM_hnRNPC; RNA recognition motif in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)
    3. XM_011536712.1XP_011535014.1  heterogeneous nuclear ribonucleoproteins C1/C2 isoform X2

      See identical proteins and their annotated locations for XP_011535014.1

      UniProtKB/Swiss-Prot
      P07910
      Related
      ENSP00000451708.1, OTTHUMP00000244322, ENST00000555914.5, OTTHUMT00000410228
      Conserved Domains (1) summary
      cd12603
      Location:1585
      RRM_hnRNPC; RNA recognition motif in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)
    4. XM_011536708.1XP_011535010.1  heterogeneous nuclear ribonucleoproteins C1/C2 isoform X1

      See identical proteins and their annotated locations for XP_011535010.1

      UniProtKB/Swiss-Prot
      P07910
      Related
      ENSP00000450790.1, OTTHUMP00000244323, ENST00000555309.5, OTTHUMT00000410229
      Conserved Domains (1) summary
      cd12603
      Location:1585
      RRM_hnRNPC; RNA recognition motif in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)
    5. XM_006720125.2XP_006720188.1  heterogeneous nuclear ribonucleoproteins C1/C2 isoform X2

      See identical proteins and their annotated locations for XP_006720188.1

      UniProtKB/Swiss-Prot
      P07910
      Related
      ENSP00000442816.1, OTTHUMP00000244320, ENST00000430246.6, OTTHUMT00000410226
      Conserved Domains (1) summary
      cd12603
      Location:1585
      RRM_hnRNPC; RNA recognition motif in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)
    6. XM_011536710.2XP_011535012.1  heterogeneous nuclear ribonucleoproteins C1/C2 isoform X1

      See identical proteins and their annotated locations for XP_011535012.1

      UniProtKB/Swiss-Prot
      P07910
      Conserved Domains (1) summary
      cd12603
      Location:1585
      RRM_hnRNPC; RNA recognition motif in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)
    7. XM_017021252.1XP_016876741.1  heterogeneous nuclear ribonucleoproteins C1/C2 isoform X2

      UniProtKB/Swiss-Prot
      P07910
      Conserved Domains (1) summary
      cd12603
      Location:1585
      RRM_hnRNPC; RNA recognition motif in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)
    8. XM_011536711.2XP_011535013.1  heterogeneous nuclear ribonucleoproteins C1/C2 isoform X1

      See identical proteins and their annotated locations for XP_011535013.1

      UniProtKB/Swiss-Prot
      P07910
      Conserved Domains (1) summary
      cd12603
      Location:1585
      RRM_hnRNPC; RNA recognition motif in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)

    Alternate CHM1_1.1

    Genomic

    1. NC_018925.2 Alternate CHM1_1.1

      Range
      21679085..21739357 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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