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    Lep leptin [ Mus musculus (house mouse) ]

    Gene ID: 16846, updated on 5-Dec-2017
    Official Symbol
    Lepprovided by MGI
    Official Full Name
    leptinprovided by MGI
    Primary source
    MGI:MGI:104663
    See related
    Ensembl:ENSMUSG00000059201 Vega:OTTMUSG00000035815
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ob; obese
    Expression
    Biased expression in subcutaneous fat pad adult (RPKM 267.7), genital fat pad adult (RPKM 183.5) and 1 other tissue See more
    Orthologs
    Location:
    6 A3.3; 6 12.3 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 6 NC_000072.6 (29060195..29073877)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (29010221..29023876)

    Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene microRNA 129-1 Neighboring gene predicted gene, 30838 Neighboring gene RNA binding motif protein 28 Neighboring gene proline-rich transmembrane protein 4

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    growth factor activity IDA
    Inferred from Direct Assay
    more info
     
    hormone activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    hormone activity ISO
    Inferred from Sequence Orthology
    more info
     
    peptide hormone receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    peptide hormone receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    T cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    activation of protein kinase C activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    activation of protein kinase C activity ISO
    Inferred from Sequence Orthology
    more info
     
    adipose tissue development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    adult feeding behavior IDA
    Inferred from Direct Assay
    more info
    PubMed 
    angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    bile acid metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    bone growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    bone mineralization involved in bone maturation ISO
    Inferred from Sequence Orthology
    more info
     
    cardiac muscle hypertrophy ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to leptin stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    central nervous system neuron development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cholesterol metabolic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    eating behavior IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    energy reserve metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    energy reserve metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    fatty acid beta-oxidation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    fatty acid catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    glucose homeostasis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    glucose metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    glycerol biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    hormone metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    insulin secretion IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    interleukin-12 production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    interleukin-6 production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    interleukin-6 secretion ISO
    Inferred from Sequence Orthology
    more info
     
    interleukin-8 secretion ISO
    Inferred from Sequence Orthology
    more info
     
    intestinal absorption ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    leptin-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    leptin-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    leukocyte tethering or rolling ISO
    Inferred from Sequence Orthology
    more info
     
    lipid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of appetite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of appetite by leptin-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    negative regulation of appetite by leptin-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of autophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cartilage development ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of glucagon secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of glucose import ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of glutamine transport ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of lipid storage ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of vasoconstriction ISO
    Inferred from Sequence Orthology
    more info
     
    ovulation from ovarian follicle ISO
    Inferred from Sequence Orthology
    more info
     
    phagocytosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phagocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    placenta development ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of JAK-STAT cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of JAK-STAT cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of MAPK cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of STAT protein import into nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of TOR signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    positive regulation of TOR signaling ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of developmental growth ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of fat cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of hepatic stellate cell activation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of insulin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of myeloid cell differentiation IDA
    Inferred from Direct Assay
    more info
     
    positive regulation of p38MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    positive regulation of p38MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of peroxisome proliferator activated receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of phosphatidylinositol 3-kinase signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of phosphatidylinositol 3-kinase signaling ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein import into nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of protein kinase B signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of reactive oxygen species metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of tumor necrosis factor production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of tyrosine phosphorylation of STAT protein ISO
    Inferred from Sequence Orthology
    more info
     
    prostaglandin secretion ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of blood pressure ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of bone remodeling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of brown fat cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of cell cycle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cytokine production involved in inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of endothelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of fat cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of gluconeogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of insulin secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of intestinal cholesterol absorption IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of lipoprotein lipid oxidation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of natural killer cell activation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of natural killer cell mediated cytotoxicity ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of natural killer cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of nitric-oxide synthase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of nitric-oxide synthase activity ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of protein localization to nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of steroid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to dietary excess IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    response to dietary excess IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to dietary excess ISO
    Inferred from Sequence Orthology
    more info
     
    response to insulin IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    sexual reproduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    sexual reproduction ISO
    Inferred from Sequence Orthology
    more info
     
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    tyrosine phosphorylation of STAT protein IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    leptin
    Names
    obesity factor

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008493.3NP_032519.1  leptin precursor

      See identical proteins and their annotated locations for NP_032519.1

      Status: VALIDATED

      Source sequence(s)
      AK030984
      Consensus CDS
      CCDS19955.1
      UniProtKB/Swiss-Prot
      P41160
      UniProtKB/TrEMBL
      Q544U0
      Related
      ENSMUSP00000067046.5, OTTMUSP00000050551, ENSMUST00000069789.11, OTTMUST00000091731
      Conserved Domains (1) summary
      pfam02024
      Location:26167
      Leptin; Leptin

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000072.6 Reference GRCm38.p4 C57BL/6J

      Range
      29060195..29073877
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006504999.1XP_006505062.1  leptin isoform X1

      See identical proteins and their annotated locations for XP_006505062.1

      Conserved Domains (1) summary
      pfam02024
      Location:26166
      Leptin; Leptin
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