Format

Send to:

Choose Destination

Links from PubMed

    • Showing Current items.

    Gh1 growth hormone 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24391, updated on 11-Jun-2017
    Official Symbol
    Gh1provided by RGD
    Official Full Name
    growth hormone 1provided by RGD
    Primary source
    RGD:2686
    See related
    Ensembl:ENSRNOG00000011207
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Gh; Ghb1; RNGHGP
    Summary
    ligand for growth hormone receptor; plays a role in a number of signaling pathways [RGD, Feb 2006]
    Location:
    10q32.1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (94486204..94488181, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 10 NC_005109.3 (94237414..94239391, complement)

    Chromosome 10 - NC_005109.4Genomic Context describing neighboring genes Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 Neighboring gene testicular cell adhesion molecule 1 Neighboring gene CD79b molecule Neighboring gene sodium voltage-gated channel alpha subunit 4 Neighboring gene uncharacterized LOC108352146

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    growth factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    growth hormone receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    growth hormone receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    hormone activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    prolactin receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    JAK-STAT cascade ISO
    Inferred from Sequence Orthology
    more info
     
    animal organ development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    bone maturation ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to alkaline pH IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to insulin stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to insulin stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to thyroid hormone stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    female pregnancy IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    glucose transport ISO
    Inferred from Sequence Orthology
    more info
     
    growth hormone receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    lung alveolus development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of neuron death IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuroblast proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of JAK-STAT cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of activation of Janus kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of insulin-like growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of multicellular organism growth IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of multicellular organism growth ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of neurogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of phosphatidylinositol 3-kinase signaling ISO
    Inferred from Sequence Orthology
    more info
     
    NOT positive regulation of receptor internalization ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of steroid hormone biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of tyrosine phosphorylation of STAT protein ISO
    Inferred from Sequence Orthology
    more info
     
    response to cytokine IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to estradiol IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to estradiol ISO
    Inferred from Sequence Orthology
    more info
     
    response to food IEA
    Inferred from Electronic Annotation
    more info
     
    response to food ISO
    Inferred from Sequence Orthology
    more info
     
    response to light stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to peptide hormone IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular region TAS
    Traceable Author Statement
    more info
     
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    growth hormone receptor complex ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    secretory granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    secretory granule ISO
    Inferred from Sequence Orthology
    more info
     
    trans-Golgi network IEA
    Inferred from Electronic Annotation
    more info
     
    trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    somatotropin
    Names
    growth hormone b1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001034848.2NP_001030020.2  somatotropin precursor

      See identical proteins and their annotated locations for NP_001030020.2

      Status: VALIDATED

      Source sequence(s)
      BC166872, BI278832, CB316202
      UniProtKB/Swiss-Prot
      P01244
      UniProtKB/TrEMBL
      B2RYR2
      Related
      ENSRNOP00000015818.4, ENSRNOT00000015818.5
      Conserved Domains (1) summary
      cd10285
      Location:35214
      somatotropin_like; Somatotropin or growth hormone (GH), placental lactogen, and related pituitary gland hormones

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005109.4 Reference Rnor_6.0 Primary Assembly

      Range
      94486204..94488181 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000078.1 Alternate Rn_Celera

      Range
      89903834..89905811 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center