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    Mr1 major histocompatibility complex, class I-related [ Mus musculus (house mouse) ]

    Gene ID: 15064, updated on 21-May-2017
    Official Symbol
    Mr1provided by MGI
    Official Full Name
    major histocompatibility complex, class I-relatedprovided by MGI
    Primary source
    MGI:MGI:1195463
    See related
    Ensembl:ENSMUSG00000026471 Vega:OTTMUSG00000049823
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    H2ls
    Orthologs
    Location:
    1; 1 G3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (155127872..155146813, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (156975008..156993910, complement)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene immediate early response 5 Neighboring gene predicted gene, 41981 Neighboring gene predicted gene, 30922 Neighboring gene syntaxin 6 Neighboring gene high mobility group protein B3 pseudogene Neighboring gene predicted gene, 46166

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    antigen processing and presentation of peptide antigen via MHC class I IEA
    Inferred from Electronic Annotation
    more info
     
    cytokine production involved in immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    defense response to Gram-negative bacterium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    interleukin-1 beta production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    interleukin-17 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    MHC class I protein complex IEA
    Inferred from Electronic Annotation
    more info
     
    endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    major histocompatibility complex class I-related gene protein
    Names
    MCH class I
    MHC class I-related gene protein
    class I histocompatibility antigen-like protein
    histocompatibility-2 complex class 1-like sequence

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008209.4NP_032235.1  major histocompatibility complex class I-related gene protein precursor

      See identical proteins and their annotated locations for NP_032235.1

      Status: PROVISIONAL

      Source sequence(s)
      AC140038
      Consensus CDS
      CCDS15383.1
      UniProtKB/Swiss-Prot
      Q8HWB0
      Related
      ENSMUSP00000027744.8, OTTMUSP00000068579, ENSMUST00000027744.9, OTTMUST00000126883
      Conserved Domains (2) summary
      cd07698
      Location:198288
      IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
      cl08246
      Location:21194
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

      Range
      155127872..155146813 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006529144.2XP_006529207.1  major histocompatibility complex class I-related gene protein isoform X2

      See identical proteins and their annotated locations for XP_006529207.1

      UniProtKB/Swiss-Prot
      Q8HWB0
      Conserved Domains (2) summary
      cd07698
      Location:86176
      IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
      cl08246
      Location:182
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
    2. XM_006529143.2XP_006529206.1  major histocompatibility complex class I-related gene protein isoform X1

      Conserved Domains (2) summary
      cd07698
      Location:127217
      IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
      cl08246
      Location:35123
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
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