Format

Send to:

Choose Destination

Links from PubMed

    • Showing Current items.

    Drd2 dopamine receptor D2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24318, updated on 27-Sep-2016
    Official Symbol
    Drd2provided by RGD
    Official Full Name
    dopamine receptor D2provided by RGD
    Primary source
    RGD:2520
    See related
    Ensembl:ENSRNOG00000008428
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
    Summary
    mediates G-protein coupled signaling; may be involved in movement disorders, schizophrenia, and drug addiction [RGD, Feb 2006]
    Orthologs
    Location:
    8q24
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (53678777..53743643)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 8 NC_005107.3 (52298097..52363814)

    Chromosome 8 - NC_005107.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102555844 Neighboring gene uncharacterized LOC102555903 Neighboring gene ankyrin repeat and kinase domain containing 1 Neighboring gene tetratricopeptide repeat domain 12 Neighboring gene uncharacterized LOC102555969

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    G-protein coupled receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    NOT adrenergic receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    dopamine binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    dopamine binding ISO
    Inferred from Sequence Orthology
    more info
     
    dopamine neurotransmitter receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    dopamine neurotransmitter receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    dopamine neurotransmitter receptor activity, coupled via Gi/Go IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dopamine neurotransmitter receptor activity, coupled via Gi/Go ISO
    Inferred from Sequence Orthology
    more info
     
    drug binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    drug binding ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    ionotropic glutamate receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    G-protein coupled receptor internalization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    G-protein coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acid secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    activation of protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    adenohypophysis development IEA
    Inferred from Electronic Annotation
    more info
     
    adenohypophysis development ISO
    Inferred from Sequence Orthology
    more info
     
    NOT adenylate cyclase-activating adrenergic receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    adenylate cyclase-inhibiting dopamine receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    adenylate cyclase-inhibiting dopamine receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    adenylate cyclase-modulating G-protein coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    adult behavior ISO
    Inferred from Sequence Orthology
    more info
     
    adult walking behavior IEA
    Inferred from Electronic Annotation
    more info
     
    adult walking behavior ISO
    Inferred from Sequence Orthology
    more info
     
    arachidonic acid secretion IEA
    Inferred from Electronic Annotation
    more info
     
    arachidonic acid secretion ISO
    Inferred from Sequence Orthology
    more info
     
    associative learning ISO
    Inferred from Sequence Orthology
    more info
     
    auditory behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    axonogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    axonogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    behavioral response to cocaine IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    behavioral response to cocaine ISO
    Inferred from Sequence Orthology
    more info
     
    behavioral response to ethanol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    behavioral response to ethanol ISO
    Inferred from Sequence Orthology
    more info
     
    branching morphogenesis of a nerve IEA
    Inferred from Electronic Annotation
    more info
     
    branching morphogenesis of a nerve ISO
    Inferred from Sequence Orthology
    more info
     
    cellular potassium ion homeostasis IC
    Inferred by Curator
    more info
    PubMed 
    cerebral cortex GABAergic interneuron migration IEA
    Inferred from Electronic Annotation
    more info
     
    cerebral cortex GABAergic interneuron migration ISO
    Inferred from Sequence Orthology
    more info
     
    circadian regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    circadian regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    dopamine metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    dopamine metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    dopamine receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dopamine receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    dopamine receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    dopamine receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    feeding behavior IEA
    Inferred from Electronic Annotation
    more info
     
    feeding behavior ISO
    Inferred from Sequence Orthology
    more info
     
    forebrain development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    grooming behavior IEA
    Inferred from Electronic Annotation
    more info
     
    grooming behavior ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    locomotory behavior ISO
    Inferred from Sequence Orthology
    more info
     
    long-term memory IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    modulation of synaptic transmission IDA
    Inferred from Direct Assay
    more info
    PubMed 
    modulation of synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of adenylate cyclase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of adenylate cyclase activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of blood pressure IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of blood pressure ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of circadian sleep/wake cycle, sleep IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of cytosolic calcium ion concentration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of dopamine receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of dopamine receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of dopamine secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of innate immune response ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of insulin secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of protein kinase B signaling IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of protein kinase B signaling ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein secretion ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of synaptic transmission, glutamatergic IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    negative regulation of synaptic transmission, glutamatergic ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of voltage-gated calcium channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of voltage-gated calcium channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    neurological system process involved in regulation of systemic arterial blood pressure IEA
    Inferred from Electronic Annotation
    more info
     
    neurological system process involved in regulation of systemic arterial blood pressure ISO
    Inferred from Sequence Orthology
    more info
     
    neuron-neuron synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
     
    orbitofrontal cortex development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    peristalsis IEA
    Inferred from Electronic Annotation
    more info
     
    peristalsis ISO
    Inferred from Sequence Orthology
    more info
     
    phosphatidylinositol metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phospholipase C-activating dopamine receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    phospholipase C-activating dopamine receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    pigmentation IEA
    Inferred from Electronic Annotation
    more info
     
    pigmentation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of ERK1 and ERK2 cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of G-protein coupled receptor protein signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cytokinesis IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cytokinesis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of dopamine uptake involved in synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of dopamine uptake involved in synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of glial cell-derived neurotrophic factor secretion IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of glial cell-derived neurotrophic factor secretion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of growth hormone secretion IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of growth hormone secretion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of long-term synaptic potentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of mitotic nuclear division TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of multicellular organism growth IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of multicellular organism growth ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of neuroblast proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of neuroblast proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of receptor internalization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of renal sodium excretion IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of renal sodium excretion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of urine volume IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of urine volume ISO
    Inferred from Sequence Orthology
    more info
     
    prepulse inhibition IEA
    Inferred from Electronic Annotation
    more info
     
    prepulse inhibition ISO
    Inferred from Sequence Orthology
    more info
     
    NOT prepulse inhibition ISO
    Inferred from Sequence Orthology
    more info
     
    protein localization IEA
    Inferred from Electronic Annotation
    more info
     
    protein localization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of MAPK cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of cAMP metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of dopamine secretion ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of dopamine uptake involved in synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of heart rate IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of heart rate ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of locomotion involved in locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of long-term neuronal synaptic plasticity IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of long-term neuronal synaptic plasticity ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of phosphoprotein phosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of potassium ion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of potassium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of sodium ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of sodium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of synapse structural plasticity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of synaptic transmission, GABAergic IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of synaptic transmission, GABAergic ISO
    Inferred from Sequence Orthology
    more info
     
    response to amphetamine IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to amphetamine ISO
    Inferred from Sequence Orthology
    more info
     
    response to axon injury IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to cocaine ISO
    Inferred from Sequence Orthology
    more info
     
    response to drug IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to drug ISO
    Inferred from Sequence Orthology
    more info
     
    response to ethanol IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to histamine IEA
    Inferred from Electronic Annotation
    more info
     
    response to histamine ISO
    Inferred from Sequence Orthology
    more info
     
    response to hypoxia IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to inactivity IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to iron ion IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to light stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    response to morphine IEA
    Inferred from Electronic Annotation
    more info
     
    response to morphine ISO
    Inferred from Sequence Orthology
    more info
     
    response to nicotine IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to toxic substance IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    sensory perception of smell IEA
    Inferred from Electronic Annotation
    more info
     
    sensory perception of smell ISO
    Inferred from Sequence Orthology
    more info
     
    startle response ISO
    Inferred from Sequence Orthology
    more info
     
    NOT startle response ISO
    Inferred from Sequence Orthology
    more info
     
    striatum development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    synapse assembly IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    synaptic transmission, dopaminergic IDA
    Inferred from Direct Assay
    more info
    PubMed 
    synaptic transmission, dopaminergic IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    temperature homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    temperature homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    visual learning IEA
    Inferred from Electronic Annotation
    more info
     
    visual learning ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    acrosomal vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    axon ISO
    Inferred from Sequence Orthology
    more info
     
    axon terminus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ciliary membrane IEA
    Inferred from Electronic Annotation
    more info
     
    ciliary membrane ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    dendritic spine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endocytic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    integral component of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    lateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    nonmotile primary cilium IEA
    Inferred from Electronic Annotation
    more info
     
    nonmotile primary cilium ISO
    Inferred from Sequence Orthology
    more info
     
    perikaryon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    postsynaptic density IDA
    Inferred from Direct Assay
    more info
    PubMed 
    sperm flagellum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    synaptic vesicle membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    D(2) dopamine receptor
    Names
    dopamine receptor 2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012547.1NP_036679.1  D(2) dopamine receptor

      See identical proteins and their annotated locations for NP_036679.1

      Status: PROVISIONAL

      Source sequence(s)
      X56065
      UniProtKB/Swiss-Prot
      P61169
      Related
      ENSRNOP00000043759, ENSRNOT00000045944
      Conserved Domains (2) summary
      pfam00001
      Location:51427
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:45233
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005107.4 Reference Rnor_6.0 Primary Assembly

      Range
      53678777..53743643
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006242979.3XP_006243041.1  

      See identical proteins and their annotated locations for XP_006243041.1

      UniProtKB/Swiss-Prot
      P61169
      Related
      ENSRNOP00000074235, ENSRNOT00000083419
      Conserved Domains (2) summary
      pfam00001
      Location:51398
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:45233
      7tm_4; Olfactory receptor

    Alternate Rn_Celera

    Genomic

    1. AC_000076.1 Alternate Rn_Celera

      Range
      49262252..49324732
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center