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    Ptpn13 protein tyrosine phosphatase, non-receptor type 13 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 498331, updated on 25-May-2017
    Official Symbol
    Ptpn13provided by RGD
    Official Full Name
    protein tyrosine phosphatase, non-receptor type 13provided by RGD
    Primary source
    RGD:1563360
    See related
    Ensembl:ENSRNOG00000002061
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    ptp; Ptp-bl
    Location:
    14p22
    Exon count:
    48
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (7688551..7863664, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 14 NC_005113.3 (7662574..7837443, complement)

    Chromosome 14 - NC_005113.4Genomic Context describing neighboring genes Neighboring gene solute carrier family 10 member 6 Neighboring gene uncharacterized LOC102546454 Neighboring gene uncharacterized LOC102546534 Neighboring gene NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4-like 1 Neighboring gene uncharacterized LOC108352699

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    phosphatidylinositol 3-kinase regulatory subunit binding IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatidylinositol 3-kinase regulatory subunit binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein tyrosine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    peptidyl-tyrosine dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    peptidyl-tyrosine dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    protein dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of phosphatidylinositol 3-kinase signaling IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of phosphatidylinositol 3-kinase signaling ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular exosome IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    lamellipodium IEA
    Inferred from Electronic Annotation
    more info
     
    lamellipodium ISO
    Inferred from Sequence Orthology
    more info
     
    midbody ISO
    Inferred from Sequence Orthology
    more info
     
    neuron projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    tyrosine-protein phosphatase non-receptor type 13
    Names
    protein Tyr phosphatase
    NP_001094259.1
    XP_017454817.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100789.1NP_001094259.1  tyrosine-protein phosphatase non-receptor type 13

      See identical proteins and their annotated locations for NP_001094259.1

      Status: VALIDATED

      Source sequence(s)
      CH474022
      UniProtKB/TrEMBL
      G3V9S3
      Related
      ENSRNOP00000057876.2, ENSRNOT00000061162.4
      Conserved Domains (10) summary
      smart00194
      Location:21852437
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00228
      Location:14881578
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      smart00295
      Location:566774
      B41; Band 4.1 homologues
      smart00750
      Location:3190
      KIND; kinase non-catalytic C-lobe domain
      cd00047
      Location:22112437
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00992
      Location:10821166
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00373
      Location:661774
      FERM_M; FERM central domain
      pfam09379
      Location:569631
      FERM_N; FERM N-terminal domain
      pfam16599
      Location:11681356
      PTN13_u3; Unstructured linker region on PTN13 protein between PDZ
      cl17171
      Location:770870
      PH-like; Pleckstrin homology-like domain

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005113.4 Reference Rnor_6.0 Primary Assembly

      Range
      7688551..7863664 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017599328.1XP_017454817.1  tyrosine-protein phosphatase non-receptor type 13 isoform X1

      Related
      ENSRNOP00000071873.1, ENSRNOT00000087081.1
      Conserved Domains (10) summary
      smart00194
      Location:21902442
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00228
      Location:14931583
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      smart00295
      Location:566774
      B41; Band 4.1 homologues
      smart00750
      Location:3190
      KIND; kinase non-catalytic C-lobe domain
      cd00047
      Location:22162442
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00992
      Location:10821166
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00373
      Location:661774
      FERM_M; FERM central domain
      pfam09379
      Location:569631
      FERM_N; FERM N-terminal domain
      pfam16599
      Location:11681356
      PTN13_u3; Unstructured linker region on PTN13 protein between PDZ
      cl17171
      Location:770870
      PH-like; Pleckstrin homology-like domain

    Alternate Rn_Celera

    Genomic

    1. AC_000082.1 Alternate Rn_Celera

      Range
      6247030..6421249 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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