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    KRT20 keratin 20 [ Homo sapiens (human) ]

    Gene ID: 54474, updated on 7-Jan-2018
    Official Symbol
    KRT20provided by HGNC
    Official Full Name
    keratin 20provided by HGNC
    Primary source
    HGNC:HGNC:20412
    See related
    Ensembl:ENSG00000171431 MIM:608218; Vega:OTTHUMG00000133366
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    K20; CD20; CK20; CK-20; KRT21
    Summary
    The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. This cytokeratin is a major cellular protein of mature enterocytes and goblet cells and is specifically expressed in the gastric and intestinal mucosa. The type I cytokeratin genes are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in small intestine (RPKM 435.8), colon (RPKM 405.3) and 3 other tissues See more
    Orthologs
    Location:
    17q21.2
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 17 NC_000017.11 (40875889..40885243, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (39032141..39041495, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene transmembrane protein 99 Neighboring gene keratin 10 Neighboring gene uncharacterized LOC105371777 Neighboring gene keratin 12 Neighboring gene uncharacterized LOC107985072 Neighboring gene keratin 23 Neighboring gene keratin 39

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Developmental Biology, organism-specific biosystem (from REACTOME)
      Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
    • Keratinization, organism-specific biosystem (from REACTOME)
      Keratinization, organism-specific biosystemKeratins are the major structural protein of vertebrate epidermis, constituting up to 85% of a fully differentiated keratinocyte (Fuchs 1995). Keratins belong to a superfamily of intermediate filamen...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC35423

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    structural constituent of cytoskeleton NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to stress IEA
    Inferred from Electronic Annotation
    more info
     
    cornification TAS
    Traceable Author Statement
    more info
     
    intermediate filament organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    keratinization TAS
    Traceable Author Statement
    more info
     
    regulation of protein secretion IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    intermediate filament NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Preferred Names
    keratin, type I cytoskeletal 20
    Names
    cytokeratin 20
    keratin 20, type I
    protein IT

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012286.1 RefSeqGene

      Range
      4985..14339
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_019010.2NP_061883.1  keratin, type I cytoskeletal 20

      See identical proteins and their annotated locations for NP_061883.1

      Status: REVIEWED

      Source sequence(s)
      BC031559, DA426874, DB242980
      Consensus CDS
      CCDS11379.1
      UniProtKB/Swiss-Prot
      P35900
      Related
      ENSP00000167588.3, OTTHUMP00000164518, ENST00000167588.3, OTTHUMT00000257202
      Conserved Domains (1) summary
      pfam00038
      Location:69380
      Filament; Intermediate filament protein

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p7 Primary Assembly

      Range
      40875889..40885243 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p7 ALT_REF_LOCI_1

    Genomic

    1. NW_003871091.1 Reference GRCh38.p7 ALT_REF_LOCI_1

      Range
      25157..34511 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018928.2 Alternate CHM1_1.1

      Range
      39267481..39276839 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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