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    SNCAIP synuclein alpha interacting protein [ Homo sapiens (human) ]

    Gene ID: 9627, updated on 6-Jun-2017
    Official Symbol
    SNCAIPprovided by HGNC
    Official Full Name
    synuclein alpha interacting proteinprovided by HGNC
    Primary source
    HGNC:HGNC:11139
    See related
    Ensembl:ENSG00000064692 MIM:603779; Vega:OTTHUMG00000128915
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Sph1; SYPH1
    Summary
    This gene encodes a protein containing several protein-protein interaction domains, including ankyrin-like repeats, a coiled-coil domain, and an ATP/GTP-binding motif. The encoded protein interacts with alpha-synuclein in neuronal tissue and may play a role in the formation of cytoplasmic inclusions and neurodegeneration. A mutation in this gene has been associated with Parkinson's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
    Orthologs
    Location:
    5q23.2
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 5 NC_000005.10 (122311354..122464219)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (121647455..121799794)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene serum response factor binding protein 1 Neighboring gene uncharacterized LOC107986445 Neighboring gene zinc finger protein 474-like Neighboring gene lysyl oxidase Neighboring gene zinc finger protein 474 Neighboring gene uncharacterized LOC107986446 Neighboring gene uncharacterized LOC153163 Neighboring gene uncharacterized LOC105379151 Neighboring gene uncharacterized LOC101927357

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Amyloid fiber formation, organism-specific biosystem (from REACTOME)
      Amyloid fiber formation, organism-specific biosystemAmyloid is a term used to describe deposits of fibrillar proteins, typically extracellular. The abnormal accumulation of amyloid, amyloidosis, is a term associated with tissue damage caused by amyloi...
    • Metabolism of proteins, organism-specific biosystem (from REACTOME)
      Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
    • Parkin-Ubiquitin Proteasomal System pathway, organism-specific biosystem (from WikiPathways)
      Parkin-Ubiquitin Proteasomal System pathway, organism-specific biosystemThis pathway describes the Parkin-Ubiquitin proteasome degradation system.
    • Parkinson's disease, organism-specific biosystem (from KEGG)
      Parkinson's disease, organism-specific biosystemParkinson's disease (PD) is a progressive neurodegenerative movement disorder that results primarily from the death of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNc). Mutations...
    • Parkinsons Disease Pathway, organism-specific biosystem (from WikiPathways)
      Parkinsons Disease Pathway, organism-specific biosystemMost people with Parkinson's disease have idiopathic Parkinson's disease (having no specific known cause). A small proportion of cases, however, can be attributed to known genetic factors. Mutations ...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC39814

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    cell death IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular protein metabolic process TAS
    Traceable Author Statement
    more info
     
    dopamine metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of inclusion body assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of neurotransmitter secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    P-body IDA
    Inferred from Direct Assay
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    neuronal cell body NAS
    Non-traceable Author Statement
    more info
    PubMed 
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    presynaptic membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    synaptic vesicle TAS
    Traceable Author Statement
    more info
    PubMed 

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_011486.1 RefSeqGene

      Range
      4945..157095
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001242935.2NP_001229864.1  synphilin-1 isoform 1A

      See identical proteins and their annotated locations for NP_001229864.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1A) differs in the 5' UTR, lacks an alternate exon in the 5' coding region that results in translation initiation from a downstream start codon in a different reading frame, and lacks two alternate exons in the central coding region, compared to variant 2. The encoded isoform (1A) has a distinct N-terminus and is shorter than isoform 2.
      Source sequence(s)
      AI702863, BC040552, DQ227317, N21998
      Consensus CDS
      CCDS58964.1
      UniProtKB/Swiss-Prot
      Q9Y6H5
      Related
      ENSP00000368854.3, ENST00000379538.7
      Conserved Domains (4) summary
      cd00204
      Location:28144
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:28121
      Ank_2; Ankyrin repeats (3 copies)
      pfam16700
      Location:146189
      SNCAIP_SNCA_bd; Synphilin-1 alpha-Synuclein-binding domain
      sd00045
      Location:5688
      ANK; ANK repeat [structural motif]
    2. NM_001308100.1NP_001295029.1  synphilin-1 isoform 2

      See identical proteins and their annotated locations for NP_001295029.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) represents the longest transcript and encodes the longest isoform (2).
      Source sequence(s)
      AF076929, AI702863, BC040552, N21998
      Consensus CDS
      CCDS78054.1
      UniProtKB/Swiss-Prot
      Q9Y6H5
      Related
      ENSP00000261367.7, OTTHUMP00000159163, ENST00000261367.11, OTTHUMT00000250889
      Conserved Domains (5) summary
      cd00204
      Location:392557
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:438534
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:397452
      Ank_4; Ankyrin repeats (many copies)
      pfam16700
      Location:559602
      SNCAIP_SNCA_bd; Synphilin-1 alpha-Synuclein-binding domain
      sd00045
      Location:396429
      ANK; ANK repeat [structural motif]
    3. NM_001308105.1NP_001295034.1  synphilin-1 isoform B

      Status: REVIEWED

      Description
      Transcript Variant: This variant (b) lacks an alternate in-frame exon in both the 5' and central coding regions, and also lacks an alternate exon that results in a frameshift in the 3' coding region, compared to variant 2. The encoded isoform (B) has a distinct C-terminus and is shorter than isoform 2. This variant lacks 5'-complete transcript support and thus its 5' UTR is incomplete.
      Source sequence(s)
      AB110789, AK299687, AK304646, AK310835, BC040552, N21998
      UniProtKB/Swiss-Prot
      Q9Y6H5
      UniProtKB/TrEMBL
      B7Z616, B7Z995
      Related
      ENSP00000422106.2, OTTHUMP00000222988, ENST00000509154.6, OTTHUMT00000371209
      Conserved Domains (4) summary
      cd00204
      Location:335450
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:335427
      Ank_2; Ankyrin repeats (3 copies)
      pfam16700
      Location:452495
      SNCAIP_SNCA_bd; Synphilin-1 alpha-Synuclein-binding domain
      sd00045
      Location:362394
      ANK; ANK repeat [structural motif]
    4. NM_001308106.1NP_001295035.1  synphilin-1 isoform D

      Status: REVIEWED

      Description
      Transcript Variant: This variant (d) lacks two alternate exons in the 5' coding region that result in translation initiation from a downstream start codon in a different reading frame, and it also lacks an alternate exon that results in a frameshift in the 3' coding region, compared to variant 2. The encoded isoform (D) has distinct N- and C-termini and is shorter than isoform 2. This variant lacks 5'-complete transcript support and thus its 5' UTR is incomplete.
      Source sequence(s)
      AB110791, AK299687, AK304646, BC040552, N21998
      UniProtKB/Swiss-Prot
      Q9Y6H5
      UniProtKB/TrEMBL
      B7Z616, B7Z995, Q6L983
      Conserved Domains (4) summary
      cd00204
      Location:26142
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:26119
      Ank_2; Ankyrin repeats (3 copies)
      pfam16700
      Location:144187
      SNCAIP_SNCA_bd; Synphilin-1 alpha-Synuclein-binding domain
      sd00045
      Location:5486
      ANK; ANK repeat [structural motif]
    5. NM_001308107.1NP_001295036.1  synphilin-1 isoform E

      Status: REVIEWED

      Description
      Transcript Variant: This variant (e) differs in the 5' UTR, lacks an alternate exon in the 5' coding region that results in translation initiation from a downstream start codon in a different reading frame, lacks two alternate exons in the central coding region, and also lacks an alternate exon that results in a frameshift in the 3' coding region, compared to variant 2. The encoded isoform (E) has distinct N- and C-termini and is shorter than isoform 2.
      Source sequence(s)
      AI702863, AK304646, BC033743, BC040552, N21998
      UniProtKB/Swiss-Prot
      Q9Y6H5
      UniProtKB/TrEMBL
      B7Z995
      Conserved Domains (4) summary
      cd00204
      Location:28144
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:28121
      Ank_2; Ankyrin repeats (3 copies)
      pfam16700
      Location:146189
      SNCAIP_SNCA_bd; Synphilin-1 alpha-Synuclein-binding domain
      sd00045
      Location:5688
      ANK; ANK repeat [structural motif]
    6. NM_001308108.1NP_001295037.1  synphilin-1 isoform F

      Status: REVIEWED

      Description
      Transcript Variant: This variant (f) lacks an alternate exon in the 5' coding region that results in translation initiation from a downstream start codon in a different reading frame, lacks an alternate exon in the central coding region, and also lacks an alternate exon that results in a frameshift in the 3' coding region, compared to variant 2. The encoded isoform (F) has distinct N- and C-termini and is shorter than isoform 2. This variant lacks 5'-complete transcript support and thus its 5' UTR is incomplete.
      Source sequence(s)
      AB110793, AK299687, AK304646, BC040552, N21998
      UniProtKB/Swiss-Prot
      Q9Y6H5
      UniProtKB/TrEMBL
      B7Z616, B7Z995, Q6L981
      Conserved Domains (5) summary
      cd00204
      Location:39204
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:85181
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:4499
      Ank_4; Ankyrin repeats (many copies)
      pfam16700
      Location:206249
      SNCAIP_SNCA_bd; Synphilin-1 alpha-Synuclein-binding domain
      sd00045
      Location:4376
      ANK; ANK repeat [structural motif]
    7. NM_001308109.1NP_001295038.1  synphilin-1 isoform G

      Status: REVIEWED

      Description
      Transcript Variant: This variant (g) differs in the 5' UTR, lacks an alternate exon in the 5' coding region that results in translation initiation from a downstream start codon in a different reading frame, lacks three alternate exons in the central coding region, and also lacks an alternate exon that results in a frameshift in the 3' coding region, compared to variant 2. The encoded isoform (G) has distinct N- and C-termini and is shorter than isoform 2.
      Source sequence(s)
      AI702863, AK304646, BC040552, N21998
      UniProtKB/Swiss-Prot
      Q9Y6H5
      UniProtKB/TrEMBL
      B7Z995
      Conserved Domains (4) summary
      cd00204
      Location:25106
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam13637
      Location:53106
      Ank_4; Ankyrin repeats (many copies)
      pfam16700
      Location:108151
      SNCAIP_SNCA_bd; Synphilin-1 alpha-Synuclein-binding domain
      sd00045
      Location:5283
      ANK; ANK repeat [structural motif]
    8. NM_005460.3NP_005451.2  synphilin-1 isoform 1

      See identical proteins and their annotated locations for NP_005451.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1, also known as variant a) differs in the 5' UTR, lacks an alternate in-frame exon in the 5' coding region, and lacks an exon that results in a frameshift in the 3' coding region, compared to variant 2. The encoded isoform (1) has a distinct C-terminus and is shorter than isoform 2.
      Source sequence(s)
      AF076929, AI702863, BC040552, N21998
      Consensus CDS
      CCDS4131.1
      UniProtKB/Swiss-Prot
      Q9Y6H5
      Related
      ENSP00000261368.8, OTTHUMP00000159162, ENST00000261368.12, OTTHUMT00000250888
      Conserved Domains (5) summary
      cd00204
      Location:345510
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:391487
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:350405
      Ank_4; Ankyrin repeats (many copies)
      pfam16700
      Location:512555
      SNCAIP_SNCA_bd; Synphilin-1 alpha-Synuclein-binding domain
      sd00045
      Location:349382
      ANK; ANK repeat [structural motif]

    RNA

    1. NR_131761.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (c) includes two additional exons in the central region but lacks an alternate exon in the 3' region, compared to variant 2. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 2, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD). This variant lacks 5'-complete transcript support and thus its 5' end is incomplete.
      Source sequence(s)
      AB110790, AK299687, AK304646, BC040552, N21998
      Related
      ENST00000395469.6, OTTHUMT00000371208
    2. NR_131762.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains an alternate 5' terminal exon, and lacks five internal exons but includes an additional internal exon, compared to variant 2. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 2, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK299687, AK304646, BC040552, N21998
      Related
      ENST00000510658.5, OTTHUMT00000371202

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p7 Primary Assembly

      Range
      122311354..122464219
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006714734.2XP_006714797.1  synphilin-1 isoform X4

      See identical proteins and their annotated locations for XP_006714797.1

      Conserved Domains (5) summary
      cd00204
      Location:345510
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:391487
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:350405
      Ank_4; Ankyrin repeats (many copies)
      pfam16700
      Location:512555
      SNCAIP_SNCA_bd; Synphilin-1 alpha-Synuclein-binding domain
      sd00045
      Location:349382
      ANK; ANK repeat [structural motif]
    2. XM_011543738.2XP_011542040.1  synphilin-1 isoform X1

      See identical proteins and their annotated locations for XP_011542040.1

      UniProtKB/Swiss-Prot
      Q9Y6H5
      Conserved Domains (5) summary
      cd00204
      Location:392557
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:438534
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:397452
      Ank_4; Ankyrin repeats (many copies)
      pfam16700
      Location:559602
      SNCAIP_SNCA_bd; Synphilin-1 alpha-Synuclein-binding domain
      sd00045
      Location:396429
      ANK; ANK repeat [structural motif]
    3. XM_017010083.1XP_016865572.1  synphilin-1 isoform X7

      Conserved Domains (4) summary
      cd00204
      Location:34150
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:34127
      Ank_2; Ankyrin repeats (3 copies)
      pfam16700
      Location:152195
      SNCAIP_SNCA_bd; Synphilin-1 alpha-Synuclein-binding domain
      sd00045
      Location:6294
      ANK; ANK repeat [structural motif]
    4. XM_011543739.1XP_011542041.1  synphilin-1 isoform X1

      See identical proteins and their annotated locations for XP_011542041.1

      UniProtKB/Swiss-Prot
      Q9Y6H5
      Conserved Domains (5) summary
      cd00204
      Location:392557
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:438534
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:397452
      Ank_4; Ankyrin repeats (many copies)
      pfam16700
      Location:559602
      SNCAIP_SNCA_bd; Synphilin-1 alpha-Synuclein-binding domain
      sd00045
      Location:396429
      ANK; ANK repeat [structural motif]
    5. XM_005272139.1XP_005272196.1  synphilin-1 isoform X4

      See identical proteins and their annotated locations for XP_005272196.1

      Conserved Domains (5) summary
      cd00204
      Location:345510
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:391487
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:350405
      Ank_4; Ankyrin repeats (many copies)
      pfam16700
      Location:512555
      SNCAIP_SNCA_bd; Synphilin-1 alpha-Synuclein-binding domain
      sd00045
      Location:349382
      ANK; ANK repeat [structural motif]
    6. XM_017010085.1XP_016865574.1  synphilin-1 isoform X10

      Conserved Domains (4) summary
      cd00204
      Location:26142
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:26119
      Ank_2; Ankyrin repeats (3 copies)
      pfam16700
      Location:144187
      SNCAIP_SNCA_bd; Synphilin-1 alpha-Synuclein-binding domain
      sd00045
      Location:5486
      ANK; ANK repeat [structural motif]
    7. XM_005272138.3XP_005272195.1  synphilin-1 isoform X4

      See identical proteins and their annotated locations for XP_005272195.1

      Conserved Domains (5) summary
      cd00204
      Location:345510
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:391487
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:350405
      Ank_4; Ankyrin repeats (many copies)
      pfam16700
      Location:512555
      SNCAIP_SNCA_bd; Synphilin-1 alpha-Synuclein-binding domain
      sd00045
      Location:349382
      ANK; ANK repeat [structural motif]
    8. XM_017010084.1XP_016865573.1  synphilin-1 isoform X9

    9. XM_017010086.1XP_016865575.1  synphilin-1 isoform X11

    10. XM_011543737.2XP_011542039.1  synphilin-1 isoform X1

      See identical proteins and their annotated locations for XP_011542039.1

      UniProtKB/Swiss-Prot
      Q9Y6H5
      Conserved Domains (5) summary
      cd00204
      Location:392557
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:438534
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:397452
      Ank_4; Ankyrin repeats (many copies)
      pfam16700
      Location:559602
      SNCAIP_SNCA_bd; Synphilin-1 alpha-Synuclein-binding domain
      sd00045
      Location:396429
      ANK; ANK repeat [structural motif]
    11. XM_017010079.1XP_016865568.1  synphilin-1 isoform X2

    12. XM_017010080.1XP_016865569.1  synphilin-1 isoform X3

      Conserved Domains (5) summary
      cd00204
      Location:392557
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:438534
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:397452
      Ank_4; Ankyrin repeats (many copies)
      pfam16700
      Location:559602
      SNCAIP_SNCA_bd; Synphilin-1 alpha-Synuclein-binding domain
      sd00045
      Location:396429
      ANK; ANK repeat [structural motif]
    13. XM_017010081.1XP_016865570.1  synphilin-1 isoform X5

      Conserved Domains (5) summary
      cd00204
      Location:392557
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:438534
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:397452
      Ank_4; Ankyrin repeats (many copies)
      pfam16700
      Location:559602
      SNCAIP_SNCA_bd; Synphilin-1 alpha-Synuclein-binding domain
      sd00045
      Location:396429
      ANK; ANK repeat [structural motif]
    14. XM_011543743.2XP_011542045.1  synphilin-1 isoform X1

      See identical proteins and their annotated locations for XP_011542045.1

      UniProtKB/Swiss-Prot
      Q9Y6H5
      Conserved Domains (5) summary
      cd00204
      Location:392557
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:438534
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:397452
      Ank_4; Ankyrin repeats (many copies)
      pfam16700
      Location:559602
      SNCAIP_SNCA_bd; Synphilin-1 alpha-Synuclein-binding domain
      sd00045
      Location:396429
      ANK; ANK repeat [structural motif]
    15. XM_011543749.2XP_011542051.1  synphilin-1 isoform X7

      Conserved Domains (4) summary
      cd00204
      Location:34150
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:34127
      Ank_2; Ankyrin repeats (3 copies)
      pfam16700
      Location:152195
      SNCAIP_SNCA_bd; Synphilin-1 alpha-Synuclein-binding domain
      sd00045
      Location:6294
      ANK; ANK repeat [structural motif]
    16. XM_011543745.1XP_011542047.1  synphilin-1 isoform X4

      See identical proteins and their annotated locations for XP_011542047.1

      Conserved Domains (5) summary
      cd00204
      Location:345510
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:391487
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:350405
      Ank_4; Ankyrin repeats (many copies)
      pfam16700
      Location:512555
      SNCAIP_SNCA_bd; Synphilin-1 alpha-Synuclein-binding domain
      sd00045
      Location:349382
      ANK; ANK repeat [structural motif]
    17. XM_017010082.1XP_016865571.1  synphilin-1 isoform X6

      UniProtKB/Swiss-Prot
      Q9Y6H5
      Conserved Domains (5) summary
      cd00204
      Location:345510
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:391487
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:350405
      Ank_4; Ankyrin repeats (many copies)
      pfam16700
      Location:512555
      SNCAIP_SNCA_bd; Synphilin-1 alpha-Synuclein-binding domain
      sd00045
      Location:349382
      ANK; ANK repeat [structural motif]
    18. XM_011543741.2XP_011542043.1  synphilin-1 isoform X1

      See identical proteins and their annotated locations for XP_011542043.1

      UniProtKB/Swiss-Prot
      Q9Y6H5
      Conserved Domains (5) summary
      cd00204
      Location:392557
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:438534
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:397452
      Ank_4; Ankyrin repeats (many copies)
      pfam16700
      Location:559602
      SNCAIP_SNCA_bd; Synphilin-1 alpha-Synuclein-binding domain
      sd00045
      Location:396429
      ANK; ANK repeat [structural motif]
    19. XM_017010078.1XP_016865567.1  synphilin-1 isoform X1

      UniProtKB/Swiss-Prot
      Q9Y6H5
      Conserved Domains (5) summary
      cd00204
      Location:392557
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:438534
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:397452
      Ank_4; Ankyrin repeats (many copies)
      pfam16700
      Location:559602
      SNCAIP_SNCA_bd; Synphilin-1 alpha-Synuclein-binding domain
      sd00045
      Location:396429
      ANK; ANK repeat [structural motif]
    20. XM_011543750.1XP_011542052.1  synphilin-1 isoform X8

      Conserved Domains (4) summary
      cd00204
      Location:26142
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:26119
      Ank_2; Ankyrin repeats (3 copies)
      pfam16700
      Location:144187
      SNCAIP_SNCA_bd; Synphilin-1 alpha-Synuclein-binding domain
      sd00045
      Location:5486
      ANK; ANK repeat [structural motif]

    RNA

    1. XR_001742362.1 RNA Sequence

    2. XR_001742363.1 RNA Sequence

    3. XR_001742364.1 RNA Sequence

    4. XR_001742365.1 RNA Sequence

    5. XR_001742366.1 RNA Sequence

    Alternate CHM1_1.1

    Genomic

    1. NC_018916.2 Alternate CHM1_1.1

      Range
      121079987..121232532
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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