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    Tlr4 toll-like receptor 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29260, updated on 16-Jan-2017
    Official Symbol
    Tlr4provided by RGD
    Official Full Name
    toll-like receptor 4provided by RGD
    Primary source
    RGD:3870
    See related
    Ensembl:ENSRNOG00000010522
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
    Summary
    receptor that functions as the major upstream sensor for hemorrhagic shock and lipopolysaccharide [RGD, Feb 2006]
    Orthologs
    Location:
    5q24
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (82587424..82601056)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 5 NC_005104.3 (86690670..86704302)

    Chromosome 5 - NC_005104.4Genomic Context describing neighboring genes Neighboring gene astrotactin 2 Neighboring gene tripartite motif-containing 32 Neighboring gene histone H2A.Z pseudogene Neighboring gene similar to 60S ribosomal protein L13 Neighboring gene similar to ribosomal protein L31

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Amoebiasis, organism-specific biosystem (from KEGG)
      Amoebiasis, organism-specific biosystemEntamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis o...
    • Amoebiasis, conserved biosystem (from KEGG)
      Amoebiasis, conserved biosystemEntamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis o...
    • Chagas disease (American trypanosomiasis), organism-specific biosystem (from KEGG)
      Chagas disease (American trypanosomiasis), organism-specific biosystemTrypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease. The parasite life cycle involves hematophagous reduviid bugs as vectors. Once parasites enter the host body, they ...
    • Chagas disease (American trypanosomiasis), conserved biosystem (from KEGG)
      Chagas disease (American trypanosomiasis), conserved biosystemTrypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease. The parasite life cycle involves hematophagous reduviid bugs as vectors. Once parasites enter the host body, they ...
    • HIF-1 signaling pathway, organism-specific biosystem (from KEGG)
      HIF-1 signaling pathway, organism-specific biosystemHypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator of oxygen homeostasis. It consists of two subunits: an inducibly-expressed HIF-1alpha subunit and a c...
    • Hepatitis B, organism-specific biosystem (from KEGG)
      Hepatitis B, organism-specific biosystemHepatitis B virus (HBV) is an enveloped virus and contains a partially double-stranded relaxed circular DNA (RC-DNA) genome. After entry into hepatocytes, HBV RC-DNA is transported to the nucleus and...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Inflammatory bowel disease (IBD), organism-specific biosystem (from KEGG)
      Inflammatory bowel disease (IBD), organism-specific biosystemInflammatory bowel disease (IBD), which includes Crohn disease (CD) and ulcerative colitis (UC), is characterized by chronic inflammation of the gastrointestinal tract due to environmental and geneti...
    • Inflammatory bowel disease (IBD), conserved biosystem (from KEGG)
      Inflammatory bowel disease (IBD), conserved biosystemInflammatory bowel disease (IBD), which includes Crohn disease (CD) and ulcerative colitis (UC), is characterized by chronic inflammation of the gastrointestinal tract due to environmental and geneti...
    • Influenza A, organism-specific biosystem (from KEGG)
      Influenza A, organism-specific biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
    • Influenza A, conserved biosystem (from KEGG)
      Influenza A, conserved biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
    • Innate Immune System, organism-specific biosystem (from REACTOME)
      Innate Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Legionellosis, organism-specific biosystem (from KEGG)
      Legionellosis, organism-specific biosystemLegionellosis is a potentially fatal infectious disease caused by the bacterium Legionella pneumophila and other legionella species. Two distinct clinical and epidemiological syndromes are associated...
    • Legionellosis, conserved biosystem (from KEGG)
      Legionellosis, conserved biosystemLegionellosis is a potentially fatal infectious disease caused by the bacterium Legionella pneumophila and other legionella species. Two distinct clinical and epidemiological syndromes are associated...
    • Leishmaniasis, organism-specific biosystem (from KEGG)
      Leishmaniasis, organism-specific biosystemLeishmania is an intracellular protozoan parasite of macrophages that causes visceral, mucosal, and cutaneous diseases. The parasite is transmitted to humans by sandflies, where they survive and prol...
    • Leishmaniasis, conserved biosystem (from KEGG)
      Leishmaniasis, conserved biosystemLeishmania is an intracellular protozoan parasite of macrophages that causes visceral, mucosal, and cutaneous diseases. The parasite is transmitted to humans by sandflies, where they survive and prol...
    • Malaria, organism-specific biosystem (from KEGG)
      Malaria, organism-specific biosystemPlasmodium protozoa are parasites that account for malaria infection. Sporozoite forms of the parasite are injected by mosquito bites under the skin and are carried to the liver where they develop in...
    • Malaria, conserved biosystem (from KEGG)
      Malaria, conserved biosystemPlasmodium protozoa are parasites that account for malaria infection. Sporozoite forms of the parasite are injected by mosquito bites under the skin and are carried to the liver where they develop in...
    • Measles, organism-specific biosystem (from KEGG)
      Measles, organism-specific biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
    • Measles, conserved biosystem (from KEGG)
      Measles, conserved biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
    • NF-kappa B signaling pathway, organism-specific biosystem (from KEGG)
      NF-kappa B signaling pathway, organism-specific biosystemNuclear factor-kappa B (NF-kappa B) is the generic name of a family of transcription factors that function as dimers and regulate genes involved in immunity, inflammation and cell survival. There are...
    • NF-kappa B signaling pathway, conserved biosystem (from KEGG)
      NF-kappa B signaling pathway, conserved biosystemNuclear factor-kappa B (NF-kappa B) is the generic name of a family of transcription factors that function as dimers and regulate genes involved in immunity, inflammation and cell survival. There are...
    • NOD-like receptor signaling pathway, organism-specific biosystem (from KEGG)
      NOD-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains mo...
    • NOD-like receptor signaling pathway, conserved biosystem (from KEGG)
      NOD-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains mo...
    • PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
      PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
    • PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
      PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
    • Pertussis, organism-specific biosystem (from KEGG)
      Pertussis, organism-specific biosystemPertussis, also known as whooping cough, is an acute respiratory infectious disease caused by a bacteria called Bordetella Pertussis. The characteristic symptoms are paroxysmal cough, inspiratory whe...
    • Pertussis, conserved biosystem (from KEGG)
      Pertussis, conserved biosystemPertussis, also known as whooping cough, is an acute respiratory infectious disease caused by a bacteria called Bordetella Pertussis. The characteristic symptoms are paroxysmal cough, inspiratory whe...
    • Phagosome, organism-specific biosystem (from KEGG)
      Phagosome, organism-specific biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
    • Phagosome, conserved biosystem (from KEGG)
      Phagosome, conserved biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
    • Proteoglycans in cancer, organism-specific biosystem (from KEGG)
      Proteoglycans in cancer, organism-specific biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
    • Proteoglycans in cancer, conserved biosystem (from KEGG)
      Proteoglycans in cancer, conserved biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
    • Regulation of TLR by endogenous ligand, organism-specific biosystem (from REACTOME)
      Regulation of TLR by endogenous ligand, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Rheumatoid arthritis, organism-specific biosystem (from KEGG)
      Rheumatoid arthritis, organism-specific biosystemRheumatoid arthritis (RA) is a chronic autoimmune joint disease where persistent inflammation affects bone remodeling leading to progressive bone destruction. In RA, abnormal activation of the immune...
    • Rheumatoid arthritis, conserved biosystem (from KEGG)
      Rheumatoid arthritis, conserved biosystemRheumatoid arthritis (RA) is a chronic autoimmune joint disease where persistent inflammation affects bone remodeling leading to progressive bone destruction. In RA, abnormal activation of the immune...
    • Salmonella infection, organism-specific biosystem (from KEGG)
      Salmonella infection, organism-specific biosystemSalmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, S...
    • Salmonella infection, conserved biosystem (from KEGG)
      Salmonella infection, conserved biosystemSalmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, S...
    • Spinal Cord Injury, organism-specific biosystem (from WikiPathways)
      Spinal Cord Injury, organism-specific biosystemThis pathway provides an overview of cell types, therapeutic targets, drugs, new proposed targets and pathways implicated in spinal cord injury. Spinal cord injury is a complex multi-step process tha...
    • TNF-alpha and mucus production in lung epythelium, organism-specific biosystem (from WikiPathways)
      TNF-alpha and mucus production in lung epythelium, organism-specific biosystemThe upregulation of mucine is regulated by three different pathways which result in the activation of NF-kB. After TNF-alpha activated its receptor and recruited several adaptor proteins, the IKK com...
    • Toll-Like Receptors Cascades, organism-specific biosystem (from REACTOME)
      Toll-Like Receptors Cascades, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Toll-like receptor signaling, organism-specific biosystem (from KEGG)
      Toll-like receptor signaling, organism-specific biosystemFunctional set; Cellular processes; Cell signaling
    • Toll-like receptor signaling, conserved biosystem (from KEGG)
      Toll-like receptor signaling, conserved biosystemFunctional set; Cellular processes; Cell signaling
    • Toll-like receptor signaling pathway, organism-specific biosystem (from KEGG)
      Toll-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
    • Toll-like receptor signaling pathway, conserved biosystem (from KEGG)
      Toll-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
    • Toll-like receptor signaling pathway, organism-specific biosystem (from WikiPathways)
      Toll-like receptor signaling pathway, organism-specific biosystem
      Toll-like receptor signaling pathway
    • Toxoplasmosis, organism-specific biosystem (from KEGG)
      Toxoplasmosis, organism-specific biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
    • Toxoplasmosis, conserved biosystem (from KEGG)
      Toxoplasmosis, conserved biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
    • Tuberculosis, organism-specific biosystem (from KEGG)
      Tuberculosis, organism-specific biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
    • Tuberculosis, conserved biosystem (from KEGG)
      Tuberculosis, conserved biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    lipopolysaccharide binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lipopolysaccharide binding IEA
    Inferred from Electronic Annotation
    more info
     
    lipopolysaccharide binding ISO
    Inferred from Sequence Orthology
    more info
     
    lipopolysaccharide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    lipopolysaccharide receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    lipopolysaccharide receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    lipopolysaccharide receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    phosphatidylinositol 3-kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    B cell proliferation involved in immune response IEA
    Inferred from Electronic Annotation
    more info
     
    B cell proliferation involved in immune response ISO
    Inferred from Sequence Orthology
    more info
     
    I-kappaB phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    I-kappaB phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    MyD88-dependent toll-like receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    activation of MAPK activity IEA
    Inferred from Electronic Annotation
    more info
     
    activation of MAPK activity ISO
    Inferred from Sequence Orthology
    more info
     
    activation of innate immune response ISO
    Inferred from Sequence Orthology
    more info
     
    astrocyte development IEA
    Inferred from Electronic Annotation
    more info
     
    astrocyte development ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to lipopolysaccharide IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to lipopolysaccharide ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to lipoteichoic acid IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to lipoteichoic acid ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to mechanical stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to mechanical stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to mechanical stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to retinoic acid IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    defense response to Gram-negative bacterium IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    defense response to Gram-negative bacterium IEA
    Inferred from Electronic Annotation
    more info
     
    defense response to Gram-negative bacterium ISO
    Inferred from Sequence Orthology
    more info
     
    detection of lipopolysaccharide IEA
    Inferred from Electronic Annotation
    more info
     
    detection of lipopolysaccharide ISO
    Inferred from Sequence Orthology
    more info
     
    detection of lipopolysaccharide ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    immunoglobulin mediated immune response IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    inflammatory response IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    innate immune response TAS
    Traceable Author Statement
    more info
    PubMed 
    innate immune response-activating signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    interferon-gamma production IEA
    Inferred from Electronic Annotation
    more info
     
    interferon-gamma production ISO
    Inferred from Sequence Orthology
    more info
     
    interleukin-1 beta secretion IEA
    Inferred from Electronic Annotation
    more info
     
    interleukin-1 beta secretion ISO
    Inferred from Sequence Orthology
    more info
     
    interleukin-1 beta secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    intestinal epithelial structure maintenance IEA
    Inferred from Electronic Annotation
    more info
     
    intestinal epithelial structure maintenance ISO
    Inferred from Sequence Orthology
    more info
     
    leukotriene metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lipopolysaccharide-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    lipopolysaccharide-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    NOT lipopolysaccharide-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    macrophage activation IEA
    Inferred from Electronic Annotation
    more info
     
    macrophage activation ISO
    Inferred from Sequence Orthology
    more info
     
    microglial cell activation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of interferon-gamma production IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of interferon-gamma production ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of interleukin-17 production IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of interleukin-17 production ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of interleukin-23 production IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of interleukin-23 production ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of interleukin-6 production IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of interleukin-6 production ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of tumor necrosis factor production IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of tumor necrosis factor production ISO
    Inferred from Sequence Orthology
    more info
     
    nitric oxide production involved in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    nitric oxide production involved in inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of B cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of B cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of DNA binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of I-kappaB kinase/NF-kappaB signaling ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of JNK cascade IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of JNK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of MHC class II biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of MHC class II biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of NF-kappaB import into nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of NF-kappaB import into nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of NF-kappaB transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of NF-kappaB transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of NLRP3 inflammasome complex assembly IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of NLRP3 inflammasome complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of NLRP3 inflammasome complex assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of chemokine production IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of chemokine production ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of interferon-alpha production IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of interferon-alpha production ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of interferon-beta biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of interferon-beta biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of interferon-beta production ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of interferon-gamma production IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of interferon-gamma production ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of interleukin-1 production IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of interleukin-1 production ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of interleukin-10 production IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of interleukin-10 production ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of interleukin-12 biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of interleukin-12 biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of interleukin-12 production ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of interleukin-6 production IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of interleukin-6 production ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of interleukin-8 biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of interleukin-8 biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of interleukin-8 production ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of lymphocyte proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of macrophage cytokine production IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of macrophage cytokine production ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of nitric oxide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of nitric oxide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of nitric-oxide synthase biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of nitric-oxide synthase biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of platelet activation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of platelet activation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of sequence-specific DNA binding transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of stress-activated MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription from RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of tumor necrosis factor biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of tumor necrosis factor biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of tumor necrosis factor production ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cytokine secretion IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of dendritic cell cytokine production IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of dendritic cell cytokine production ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of sensory perception of pain IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to activity IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to bacterium ISO
    Inferred from Sequence Orthology
    more info
     
    response to ethanol IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to fatty acid IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to glucocorticoid IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to gold nanoparticle IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to hypoxia IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to insulin IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to lipopolysaccharide IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to lipopolysaccharide IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to lipopolysaccharide ISO
    Inferred from Sequence Orthology
    more info
     
    response to morphine IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to progesterone IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to retinoic acid IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to toxic substance IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    skeletal muscle contraction IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    toll-like receptor 4 signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    toll-like receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    intrinsic component of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    lipopolysaccharide receptor complex IEA
    Inferred from Electronic Annotation
    more info
     
    lipopolysaccharide receptor complex ISO
    Inferred from Sequence Orthology
    more info
     
    lipopolysaccharide receptor complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    colocalizes_with membrane raft IDA
    Inferred from Direct Assay
    more info
    PubMed 
    perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    toll-like receptor 4
    Names
    toll4

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019178.1NP_062051.1  toll-like receptor 4 precursor

      See identical proteins and their annotated locations for NP_062051.1

      Status: PROVISIONAL

      Source sequence(s)
      AF057025
      UniProtKB/Swiss-Prot
      Q9QX05
      Related
      ENSRNOP00000014020, ENSRNOT00000014020
      Conserved Domains (4) summary
      smart00255
      Location:672813
      TIR; Toll - interleukin 1 - resistance
      cd00116
      Location:369555
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:5878
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:56113
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005104.4 Reference Rnor_6.0 Primary Assembly

      Range
      82587424..82601056
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000073.1 Alternate Rn_Celera

      Range
      79045293..79058928
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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