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    Myo5a myosin VA [ Mus musculus (house mouse) ]

    Gene ID: 17918, updated on 7-May-2017
    Official Symbol
    Myo5aprovided by MGI
    Official Full Name
    myosin VAprovided by MGI
    Primary source
    MGI:MGI:105976
    See related
    Ensembl:ENSMUSG00000034593 Vega:OTTMUSG00000016492
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    d; Dbv; MVa; flr; Myo5; MyoVA; Sev-1; flail; d-120J; AI413174; AI661011; 9630007J19Rik
    Orthologs
    Location:
    9 D; 9 42.26 cM
    Exon count:
    43
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 9 NC_000075.6 (75071015..75223688)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (74919013..75071495)

    Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene cAMP-regulated phosphoprotein 19 Neighboring gene apoptosis inhibitor 5 pseudogene Neighboring gene branched chain ketoacid dehydrogenase E1, beta polypeptide pseudogene Neighboring gene predicted gene, 33750 Neighboring gene myosin VC Neighboring gene uncharacterized LOC102636700 Neighboring gene guanine nucleotide binding protein (G protein), beta 5

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Spontaneous (55)  1 citation
    • Chemically and radiation induced (1) 
    • Targeted (2) 
    • Chemically induced (ENU) (24)  1 citation
    • Radiation induced (11) 
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    ATP-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    Rab GTPase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Rab GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    SNARE binding ISO
    Inferred from Sequence Orthology
    more info
     
    actin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    calcium ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    calcium-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    calmodulin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    disordered domain specific binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    microfilament motor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    microfilament motor activity ISO
    Inferred from Sequence Orthology
    more info
     
    motor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    motor activity ISO
    Inferred from Sequence Orthology
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein dimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    syntaxin-1 binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    actin filament-based movement IDA
    Inferred from Direct Assay
    more info
    PubMed 
    actin filament-based movement ISO
    Inferred from Sequence Orthology
    more info
     
    anagen IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    axo-dendritic protein transport ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to insulin stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    developmental pigmentation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    endoplasmic reticulum localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    exocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    hair follicle maturation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    insulin secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    locomotion involved in locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    long-chain fatty acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    melanin biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    melanin metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    melanocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    melanosome localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    melanosome transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    melanosome transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    myelination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neuromuscular process controlling balance IMP
    Inferred from Mutant Phenotype
    more info
     
    odontogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    pigmentation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    pigmentation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of cellular response to insulin stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of vascular associated smooth muscle cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    post-Golgi vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
     
    protein localization to plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of exocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    secretory granule localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    secretory granule localization ISO
    Inferred from Sequence Orthology
    more info
     
    synapse organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    vesicle transport along actin filament ISO
    Inferred from Sequence Orthology
    more info
     
    vesicle transport along actin filament TAS
    Traceable Author Statement
    more info
    PubMed 
    vesicle-mediated transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    visual perception IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with actin filament ISO
    Inferred from Sequence Orthology
    more info
     
    actomyosin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    actomyosin, myosin complex part ISO
    Inferred from Sequence Orthology
    more info
     
    axon ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with early endosome ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    filopodium tip ISO
    Inferred from Sequence Orthology
    more info
     
    insulin-responsive compartment IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intermediate filament IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intracellular ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with late endosome ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with lysosome ISO
    Inferred from Sequence Orthology
    more info
     
    melanosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with microtubule plus-end IDA
    Inferred from Direct Assay
    more info
    PubMed 
    myosin complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with peroxisome ISO
    Inferred from Sequence Orthology
    more info
     
    photoreceptor outer segment IDA
    Inferred from Direct Assay
    more info
    PubMed 
    recycling endosome ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with recycling endosome ISO
    Inferred from Sequence Orthology
    more info
     
    ruffle ISO
    Inferred from Sequence Orthology
    more info
     
    secretory granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    secretory granule ISO
    Inferred from Sequence Orthology
    more info
     
    synaptic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    unconventional myosin complex IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    colocalizes_with vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    unconventional myosin-Va
    Names
    dilute lethal-20J protein
    dilute myosin heavy chain, non-muscle
    flailer
    myosin-Va

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010864.2NP_034994.2  unconventional myosin-Va

      See identical proteins and their annotated locations for NP_034994.2

      Status: VALIDATED

      Source sequence(s)
      AC133947, AK002362, AK134367, AK149701, CN459715, X57377
      Consensus CDS
      CCDS52860.1
      UniProtKB/Swiss-Prot
      Q99104
      Related
      ENSMUSP00000116028.1, OTTMUSP00000017756, ENSMUST00000123128.7, OTTMUST00000039803
      Conserved Domains (7) summary
      smart00015
      Location:813835
      IQ; Calmodulin-binding motif
      cd15478
      Location:14791853
      Myo5a_CBD; Cargo binding domain of myosin 5a
      cd01380
      Location:83751
      MYSc_Myo5; class V myosin, motor domain
      pfam00063
      Location:72751
      Myosin_head; Myosin head (motor domain)
      pfam00261
      Location:9281177
      Tropomyosin; Tropomyosin
      pfam15898
      Location:9421041
      PRKG1_interact; cGMP-dependent protein kinase interacting domain
      cl23720
      Location:9991098
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000075.6 Reference GRCm38.p4 C57BL/6J

      Range
      75071015..75223688
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006510827.3XP_006510890.1  unconventional myosin-Va isoform X1

      Conserved Domains (7) summary
      smart00015
      Location:813835
      IQ; Calmodulin-binding motif
      cd15478
      Location:15061880
      Myo5a_CBD; Cargo binding domain of myosin 5a
      cd01380
      Location:83751
      MYSc_Myo5; class V myosin, motor domain
      pfam00063
      Location:72751
      Myosin_head; Myosin head (motor domain)
      pfam00261
      Location:9281177
      Tropomyosin; Tropomyosin
      pfam15898
      Location:9421041
      PRKG1_interact; cGMP-dependent protein kinase interacting domain
      cl23720
      Location:9991098
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    2. XM_006510829.3XP_006510892.1  unconventional myosin-Va isoform X3

      UniProtKB/TrEMBL
      D3Z4J3
      Related
      ENSMUSP00000117493.2, OTTMUSP00000019176, ENSMUST00000155282.8, OTTMUST00000042678
      Conserved Domains (7) summary
      smart00015
      Location:813835
      IQ; Calmodulin-binding motif
      cd15478
      Location:14811855
      Myo5a_CBD; Cargo binding domain of myosin 5a
      cd01380
      Location:83751
      MYSc_Myo5; class V myosin, motor domain
      pfam00063
      Location:72751
      Myosin_head; Myosin head (motor domain)
      pfam00261
      Location:9281177
      Tropomyosin; Tropomyosin
      pfam15898
      Location:9421041
      PRKG1_interact; cGMP-dependent protein kinase interacting domain
      cl23720
      Location:9991098
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    3. XM_006510832.3XP_006510895.1  unconventional myosin-Va isoform X6

      UniProtKB/TrEMBL
      D3YZ62
      Related
      ENSMUSP00000120444.1, OTTMUSP00000046608, ENSMUST00000136731.7, OTTMUST00000086153
      Conserved Domains (7) summary
      smart00015
      Location:813835
      IQ; Calmodulin-binding motif
      cd15478
      Location:14541828
      Myo5a_CBD; Cargo binding domain of myosin 5a
      cd01380
      Location:83751
      MYSc_Myo5; class V myosin, motor domain
      pfam00063
      Location:72751
      Myosin_head; Myosin head (motor domain)
      pfam00261
      Location:9281177
      Tropomyosin; Tropomyosin
      pfam15898
      Location:9421041
      PRKG1_interact; cGMP-dependent protein kinase interacting domain
      cl23720
      Location:9991098
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    4. XM_006510828.3XP_006510891.1  unconventional myosin-Va isoform X2

      Conserved Domains (7) summary
      smart00015
      Location:813835
      IQ; Calmodulin-binding motif
      cd15478
      Location:15031877
      Myo5a_CBD; Cargo binding domain of myosin 5a
      cd01380
      Location:83751
      MYSc_Myo5; class V myosin, motor domain
      pfam00063
      Location:72751
      Myosin_head; Myosin head (motor domain)
      pfam00261
      Location:9281177
      Tropomyosin; Tropomyosin
      pfam15898
      Location:9421041
      PRKG1_interact; cGMP-dependent protein kinase interacting domain
      cl23720
      Location:9991098
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    5. XM_006510830.3XP_006510893.1  unconventional myosin-Va isoform X4

      Conserved Domains (7) summary
      smart00015
      Location:813835
      IQ; Calmodulin-binding motif
      cd15478
      Location:14781852
      Myo5a_CBD; Cargo binding domain of myosin 5a
      cd01380
      Location:83751
      MYSc_Myo5; class V myosin, motor domain
      pfam00063
      Location:72751
      Myosin_head; Myosin head (motor domain)
      pfam00261
      Location:9281177
      Tropomyosin; Tropomyosin
      pfam15898
      Location:9421041
      PRKG1_interact; cGMP-dependent protein kinase interacting domain
      cl23720
      Location:9991098
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    6. XM_006510831.3XP_006510894.1  unconventional myosin-Va isoform X5

      Conserved Domains (7) summary
      smart00015
      Location:813835
      IQ; Calmodulin-binding motif
      cd15478
      Location:14761850
      Myo5a_CBD; Cargo binding domain of myosin 5a
      cd01380
      Location:83751
      MYSc_Myo5; class V myosin, motor domain
      pfam00063
      Location:72751
      Myosin_head; Myosin head (motor domain)
      pfam00261
      Location:9281177
      Tropomyosin; Tropomyosin
      pfam15898
      Location:9421041
      PRKG1_interact; cGMP-dependent protein kinase interacting domain
      cl23720
      Location:9991098
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    7. XM_006510834.3XP_006510897.1  unconventional myosin-Va isoform X7

      Conserved Domains (4) summary
      smart00015
      Location:2547
      IQ; Calmodulin-binding motif
      pfam15898
      Location:154253
      PRKG1_interact; cGMP-dependent protein kinase interacting domain
      cl03379
      Location:7181092
      Myo5-like_CBD; Cargo binding domain of myosin 5 and similar proteins
      cl23720
      Location:211310
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
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