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    Cdh1 cadherin 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 83502, updated on 12-Mar-2017
    Official Symbol
    Cdh1provided by RGD
    Official Full Name
    cadherin 1provided by RGD
    Primary source
    RGD:69279
    See related
    Ensembl:ENSRNOG00000020151
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    cell-cell adhesion molecule; may play a role in axonal growth and synase formation [RGD, Feb 2006]
    Orthologs
    Location:
    19q12
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (38768467..38838395)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 19 NC_005118.3 (49635965..49705893)

    Chromosome 19 - NC_005118.4Genomic Context describing neighboring genes Neighboring gene ribosomal protein L28-like Neighboring gene cadherin 3 Neighboring gene transport and golgi organization 6 homolog Neighboring gene hyaluronan synthase 3 Neighboring gene chromosome transmission fidelity factor 8

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    GTPase activating protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    GTPase activating protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    alpha-catenin binding ISO
    Inferred from Sequence Orthology
    more info
     
    ankyrin binding IEA
    Inferred from Electronic Annotation
    more info
     
    ankyrin binding ISO
    Inferred from Sequence Orthology
    more info
     
    beta-catenin binding IEA
    Inferred from Electronic Annotation
    more info
     
    beta-catenin binding ISO
    Inferred from Sequence Orthology
    more info
     
    cadherin binding IEA
    Inferred from Electronic Annotation
    more info
     
    cadherin binding ISO
    Inferred from Sequence Orthology
    more info
     
    calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    cell adhesion molecule binding ISO
    Inferred from Sequence Orthology
    more info
     
    cytoskeletal protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    gamma-catenin binding IEA
    Inferred from Electronic Annotation
    more info
     
    gamma-catenin binding ISO
    Inferred from Sequence Orthology
    more info
     
    glycoprotein binding IEA
    Inferred from Electronic Annotation
    more info
     
    glycoprotein binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    adherens junction organization IEA
    Inferred from Electronic Annotation
    more info
     
    adherens junction organization ISO
    Inferred from Sequence Orthology
    more info
     
    bicellular tight junction assembly ISO
    Inferred from Sequence Orthology
    more info
     
    calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to amino acid stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to indole-3-methanol IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to indole-3-methanol ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to lithium ion IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to lithium ion ISO
    Inferred from Sequence Orthology
    more info
     
    cochlea development ISO
    Inferred from Sequence Orthology
    more info
     
    decidualization ISO
    Inferred from Sequence Orthology
    more info
     
    embryo implantation ISO
    Inferred from Sequence Orthology
    more info
     
    epithelial cell morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    establishment of protein localization to plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    establishment of protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    homophilic cell adhesion via plasma membrane adhesion molecules IEA
    Inferred from Electronic Annotation
    more info
     
    in utero embryonic development ISO
    Inferred from Sequence Orthology
    more info
     
    intestinal epithelial cell development ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of epithelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein processing ISO
    Inferred from Sequence Orthology
    more info
     
    neuron projection development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    pituitary gland development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    positive regulation of cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription factor import into nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of transcription factor import into nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    protein homooligomerization ISO
    Inferred from Sequence Orthology
    more info
     
    protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    protein metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of branching involved in salivary gland morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of neuron migration ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of protein localization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of protein localization to cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of water loss via skin ISO
    Inferred from Sequence Orthology
    more info
     
    response to drug IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to organic substance IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to toxic substance IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    salivary gland cavitation ISO
    Inferred from Sequence Orthology
    more info
     
    sensory perception of sound ISO
    Inferred from Sequence Orthology
    more info
     
    single organismal cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    single organismal cell-cell adhesion TAS
    Traceable Author Statement
    more info
    PubMed 
    synapse assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    trophectodermal cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    uterine epithelium development ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    Schmidt-Lanterman incisure ISO
    Inferred from Sequence Orthology
    more info
     
    actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    adherens junction ISO
    Inferred from Sequence Orthology
    more info
     
    apical junction complex IEA
    Inferred from Electronic Annotation
    more info
     
    apical junction complex ISO
    Inferred from Sequence Orthology
    more info
     
    apical part of cell ISO
    Inferred from Sequence Orthology
    more info
     
    axon ISO
    Inferred from Sequence Orthology
    more info
     
    axon terminus ISO
    Inferred from Sequence Orthology
    more info
     
    basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    catenin complex IEA
    Inferred from Electronic Annotation
    more info
     
    catenin complex ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with catenin complex ISO
    Inferred from Sequence Orthology
    more info
     
    cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    cell periphery ISO
    Inferred from Sequence Orthology
    more info
     
    cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    cell-cell adherens junction IEA
    Inferred from Electronic Annotation
    more info
     
    cell-cell adherens junction ISO
    Inferred from Sequence Orthology
    more info
     
    cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    cortical actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with cortical actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasmic side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasmic side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    endosome IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular exosome IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    flotillin complex IEA
    Inferred from Electronic Annotation
    more info
     
    flotillin complex ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of membrane ISO
    Inferred from Sequence Orthology
    more info
     
    lamellipodium IEA
    Inferred from Electronic Annotation
    more info
     
    lamellipodium ISO
    Inferred from Sequence Orthology
    more info
     
    lateral loop ISO
    Inferred from Sequence Orthology
    more info
     
    lateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    lateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    node of Ranvier ISO
    Inferred from Sequence Orthology
    more info
     
    perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    trans-Golgi network IEA
    Inferred from Electronic Annotation
    more info
     
    trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    cadherin-1
    Names
    E-cadherin
    epithelial cadherin
    uvomorulin

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031334.1NP_112624.1  cadherin-1 precursor

      See identical proteins and their annotated locations for NP_112624.1

      Status: PROVISIONAL

      Source sequence(s)
      AB017696
      UniProtKB/Swiss-Prot
      Q9R0T4
      Related
      ENSRNOP00000027346, ENSRNOT00000027346
      Conserved Domains (5) summary
      cd00031
      Location:162262
      CA_like; Cadherin repeat-like domain
      cd11304
      Location:270375
      Cadherin_repeat; Cadherin tandem repeat domain
      pfam00028
      Location:608690
      Cadherin; Cadherin domain
      pfam01049
      Location:745881
      Cadherin_C; Cadherin cytoplasmic region
      pfam08758
      Location:31120
      Cadherin_pro; Cadherin prodomain like

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005118.4 Reference Rnor_6.0 Primary Assembly

      Range
      38768467..38838395
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000087.1 Alternate Rn_Celera

      Range
      33919043..33988306
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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