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    Ppp1r12a protein phosphatase 1, regulatory subunit 12A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 116670, updated on 11-Jun-2017
    Official Symbol
    Ppp1r12aprovided by RGD
    Official Full Name
    protein phosphatase 1, regulatory subunit 12Aprovided by RGD
    Primary source
    RGD:620013
    See related
    Ensembl:ENSRNOG00000004925
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    M110; MBSP; Mypt1
    Summary
    selectively binds to PP-1C and increases the substrate specificity of the phosphatase towards myosin [RGD, Feb 2006]
    Orthologs
    Location:
    7q21
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (51404971..51515382, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 7 NC_005106.3 (51417546..51527960, complement)

    Chromosome 7 - NC_005106.4Genomic Context describing neighboring genes Neighboring gene similar to histone deacetylase 1 Neighboring gene 60S ribosomal protein L26-like Neighboring gene pro-apoptotic WT1 regulator Neighboring gene similar to 60S ribosomal protein L7a (Surfeit locus protein 3) Neighboring gene otogelin-like

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    14-3-3 protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    14-3-3 protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    14-3-3 protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enzyme inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enzyme inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enzyme inhibitor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    phosphatase regulator activity IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatase regulator activity ISO
    Inferred from Sequence Orthology
    more info
     
    phosphatase regulator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    phosphoprotein phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    cellular response to drug IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to drug ISO
    Inferred from Sequence Orthology
    more info
     
    centrosome cycle IEA
    Inferred from Electronic Annotation
    more info
     
    centrosome cycle ISO
    Inferred from Sequence Orthology
    more info
     
    centrosome cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    mitotic cell cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of catalytic activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of catalytic activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of myosin-light-chain-phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of myosin-light-chain-phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription from RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription from RNA polymerase II promoter ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    protein dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    protein dephosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cell adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    NOT regulation of establishment of endothelial barrier ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of myosin-light-chain-phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of myosin-light-chain-phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of nucleocytoplasmic transport IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of nucleocytoplasmic transport ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    A band IEA
    Inferred from Electronic Annotation
    more info
     
    A band ISO
    Inferred from Sequence Orthology
    more info
     
    A band ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    PTW/PP1 phosphatase complex IEA
    Inferred from Electronic Annotation
    more info
     
    PTW/PP1 phosphatase complex ISO
    Inferred from Sequence Orthology
    more info
     
    PTW/PP1 phosphatase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Z disc IEA
    Inferred from Electronic Annotation
    more info
     
    Z disc ISO
    Inferred from Sequence Orthology
    more info
     
    Z disc ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    centrosome IEA
    Inferred from Electronic Annotation
    more info
     
    centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    centrosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    contractile fiber ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    focal adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    focal adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    kinetochore IEA
    Inferred from Electronic Annotation
    more info
     
    kinetochore ISO
    Inferred from Sequence Orthology
    more info
     
    kinetochore ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Preferred Names
    protein phosphatase 1 regulatory subunit 12A
    Names
    PP-1M
    myosin phosphatase, target subunit 1
    myosin phosphatase-targeting subunit 1
    protein phosphatase 1, regulatory (inhibitor) subunit 12A
    protein phosphatase myosin-binding subunit
    protein phosphatase subunit 1M
    serine/threonine protein phosphatase PP1 smooth muscle regulatory subunit M110
    smooth muscle myosin phosphatase myosin-binding subunit

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053890.1NP_446342.1  protein phosphatase 1 regulatory subunit 12A

      See identical proteins and their annotated locations for NP_446342.1

      Status: PROVISIONAL

      Source sequence(s)
      S74907
      UniProtKB/Swiss-Prot
      Q10728
      Related
      ENSRNOP00000040934.5, ENSRNOT00000050037.6
      Conserved Domains (5) summary
      cd00204
      Location:67252
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:47136
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:199252
      Ank_4; Ankyrin repeats (many copies)
      pfam15898
      Location:877975
      PRKG1_interact; cGMP-dependent protein kinase interacting domain
      sd00045
      Location:72103
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005106.4 Reference Rnor_6.0 Primary Assembly

      Range
      51404971..51515382 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006241316.3XP_006241378.1  protein phosphatase 1 regulatory subunit 12A isoform X8

      Conserved Domains (4) summary
      cd00204
      Location:9104
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam13637
      Location:2376
      Ank_4; Ankyrin repeats (many copies)
      pfam15898
      Location:795893
      PRKG1_interact; cGMP-dependent protein kinase interacting domain
      sd00045
      Location:2253
      ANK; ANK repeat [structural motif]
    2. XM_006241315.2XP_006241377.1  protein phosphatase 1 regulatory subunit 12A isoform X7

      See identical proteins and their annotated locations for XP_006241377.1

      UniProtKB/Swiss-Prot
      Q10728
      Related
      ENSRNOP00000045260.4, ENSRNOT00000041473.5
      Conserved Domains (5) summary
      cd00204
      Location:67252
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:47136
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:199252
      Ank_4; Ankyrin repeats (many copies)
      pfam15898
      Location:873971
      PRKG1_interact; cGMP-dependent protein kinase interacting domain
      sd00045
      Location:72103
      ANK; ANK repeat [structural motif]
    3. XM_006241311.2XP_006241373.1  protein phosphatase 1 regulatory subunit 12A isoform X3

      See identical proteins and their annotated locations for XP_006241373.1

      UniProtKB/TrEMBL
      A0A0G2JWJ0
      Related
      ENSRNOP00000069900.1, ENSRNOT00000080285.1
      Conserved Domains (5) summary
      cd00204
      Location:67252
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:47136
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:199252
      Ank_4; Ankyrin repeats (many copies)
      pfam15898
      Location:9331031
      PRKG1_interact; cGMP-dependent protein kinase interacting domain
      sd00045
      Location:72103
      ANK; ANK repeat [structural motif]
    4. XM_006241314.2XP_006241376.1  protein phosphatase 1 regulatory subunit 12A isoform X6

      See identical proteins and their annotated locations for XP_006241376.1

      Conserved Domains (5) summary
      cd00204
      Location:67252
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:47136
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:199252
      Ank_4; Ankyrin repeats (many copies)
      pfam15898
      Location:933987
      PRKG1_interact; cGMP-dependent protein kinase interacting domain
      sd00045
      Location:72103
      ANK; ANK repeat [structural motif]
    5. XM_006241312.2XP_006241374.1  protein phosphatase 1 regulatory subunit 12A isoform X4

      Conserved Domains (5) summary
      cd00204
      Location:67252
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:47136
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:199252
      Ank_4; Ankyrin repeats (many copies)
      pfam15898
      Location:9151013
      PRKG1_interact; cGMP-dependent protein kinase interacting domain
      sd00045
      Location:72103
      ANK; ANK repeat [structural motif]
    6. XM_006241313.2XP_006241375.1  protein phosphatase 1 regulatory subunit 12A isoform X5

      Conserved Domains (5) summary
      cd00204
      Location:67252
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:47136
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:199252
      Ank_4; Ankyrin repeats (many copies)
      pfam15898
      Location:9111009
      PRKG1_interact; cGMP-dependent protein kinase interacting domain
      sd00045
      Location:72103
      ANK; ANK repeat [structural motif]
    7. XM_006241308.2XP_006241370.1  protein phosphatase 1 regulatory subunit 12A isoform X1

      Conserved Domains (5) summary
      cd00204
      Location:67252
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:47136
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:199252
      Ank_4; Ankyrin repeats (many copies)
      pfam15898
      Location:9711069
      PRKG1_interact; cGMP-dependent protein kinase interacting domain
      sd00045
      Location:72103
      ANK; ANK repeat [structural motif]
    8. XM_006241309.2XP_006241371.1  protein phosphatase 1 regulatory subunit 12A isoform X2

      Conserved Domains (5) summary
      cd00204
      Location:67252
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:47136
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:199252
      Ank_4; Ankyrin repeats (many copies)
      pfam15898
      Location:9711025
      PRKG1_interact; cGMP-dependent protein kinase interacting domain
      sd00045
      Location:72103
      ANK; ANK repeat [structural motif]

    Alternate Rn_Celera

    Genomic

    1. AC_000075.1 Alternate Rn_Celera

      Range
      40349341..40458007
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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