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    NEUROG3 neurogenin 3 [ Homo sapiens (human) ]

    Gene ID: 50674, updated on 12-Nov-2017
    Official Symbol
    NEUROG3provided by HGNC
    Official Full Name
    neurogenin 3provided by HGNC
    Primary source
    HGNC:HGNC:13806
    See related
    Ensembl:ENSG00000122859 MIM:604882; Vega:OTTHUMG00000018391
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ngn3; Atoh5; NGN-3; Math4B; bHLHa7
    Summary
    The protein encoded by this gene is a basic helix-loop-helix (bHLH) transcription factor involved in neurogenesis. The encoded protein likely acts as a heterodimer with another bHLH protein. Defects in this gene are a cause of congenital malabsorptive diarrhea 4 (DIAR4).[provided by RefSeq, May 2010]
    Orthologs
    Location:
    10q22.1
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 10 NC_000010.11 (69571440..69573454, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (71331791..71333210, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene tetraspanin 15 Neighboring gene transmembrane protein 256 pseudogene 1 Neighboring gene uncharacterized LOC105378345 Neighboring gene uncharacterized LOC101929021 Neighboring gene mitochondrially encoded ATP synthase 6 pseudogene 23 Neighboring gene mitochondrially encoded cytochrome c oxidase II pseudogene 23

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Replication interactions

    Interaction Pubs
    Knockdown of neurogenin 3 (NEUROG3) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

    Go to the HIV-1, Human Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    RNA polymerase II proximal promoter sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromatin DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    core promoter binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    transcription coactivator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    central nervous system development TAS
    Traceable Author Statement
    more info
    PubMed 
    endocrine pancreas development IEA
    Inferred from Electronic Annotation
    more info
     
    epithelial cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    forebrain development IEA
    Inferred from Electronic Annotation
    more info
     
    hindbrain development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nervous system development TAS
    Traceable Author Statement
    more info
    PubMed 
    peripheral nervous system development TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of DNA binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of dendrite morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    spinal cord development IEA
    Inferred from Electronic Annotation
    more info
     
    transcription from RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
     
    transdifferentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    neurogenin-3
    Names
    class A basic helix-loop-helix protein 7
    protein atonal homolog 5

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_021321.1 RefSeqGene

      Range
      5001..6420
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_020999.3NP_066279.2  neurogenin-3

      See identical proteins and their annotated locations for NP_066279.2

      Status: REVIEWED

      Source sequence(s)
      AK313952, BC069098
      Consensus CDS
      CCDS31212.1
      UniProtKB/Swiss-Prot
      Q9Y4Z2
      Related
      ENSP00000242462.4, OTTHUMP00000019730, ENST00000242462.4, OTTHUMT00000048464
      Conserved Domains (1) summary
      cd00083
      Location:81140
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p7 Primary Assembly

      Range
      69571440..69573454 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017016280.1XP_016871769.1  neurogenin-3 isoform X1

      UniProtKB/Swiss-Prot
      Q9Y4Z2
      Conserved Domains (1) summary
      cd00083
      Location:81140
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

    Alternate CHM1_1.1

    Genomic

    1. NC_018921.2 Alternate CHM1_1.1

      Range
      71613524..71614943 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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