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    Drd3 dopamine receptor D3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29238, updated on 25-May-2017
    Official Symbol
    Drd3provided by RGD
    Official Full Name
    dopamine receptor D3provided by RGD
    Primary source
    RGD:2521
    See related
    Ensembl:ENSRNOG00000060806
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    may be involved in facilitating the effects of antipsychotic drugs and drug treatments for Parkinson's disease [RGD, Feb 2006]
    Orthologs
    Location:
    11q21
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (61819102..61883223, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 11 NC_005110.3 (60955136..61016058, complement)

    Chromosome 11 - NC_005110.4Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 191 Neighboring gene queuine tRNA-ribosyltransferase accessory subunit 2 Neighboring gene uncharacterized LOC103693574 Neighboring gene T cell immunoreceptor with Ig and ITIM domains

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    D1 dopamine receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    dopamine binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    dopamine neurotransmitter receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    dopamine neurotransmitter receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    dopamine neurotransmitter receptor activity, coupled via Gi/Go IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dopamine neurotransmitter receptor activity, coupled via Gi/Go ISO
    Inferred from Sequence Orthology
    more info
     
    drug binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    drug binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    G-protein coupled receptor internalization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    G-protein coupled receptor internalization ISO
    Inferred from Sequence Orthology
    more info
     
    G-protein coupled receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    G-protein coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acid secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    adenylate cyclase-activating dopamine receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    adenylate cyclase-activating dopamine receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    adenylate cyclase-inhibiting dopamine receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    adenylate cyclase-inhibiting dopamine receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    arachidonic acid secretion IEA
    Inferred from Electronic Annotation
    more info
     
    arachidonic acid secretion ISO
    Inferred from Sequence Orthology
    more info
     
    behavioral response to cocaine IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    behavioral response to cocaine ISO
    Inferred from Sequence Orthology
    more info
     
    cellular calcium ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    cellular calcium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    circadian regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    circadian regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    dopamine receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    dopamine receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    gastric emptying IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    locomotory behavior IEA
    Inferred from Electronic Annotation
    more info
     
    locomotory behavior ISO
    Inferred from Sequence Orthology
    more info
     
    NOT locomotory behavior ISO
    Inferred from Sequence Orthology
    more info
     
    musculoskeletal movement, spinal reflex action IEA
    Inferred from Electronic Annotation
    more info
     
    musculoskeletal movement, spinal reflex action ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of adenylate cyclase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of adenylate cyclase activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of blood pressure IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of blood pressure ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of dopamine receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of dopamine receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of oligodendrocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of oligodendrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein kinase B signaling IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of protein kinase B signaling ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein secretion IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of protein secretion ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of sodium:proton antiporter activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cytokinesis IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cytokinesis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of dopamine receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of dopamine receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of mitotic nuclear division IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of renal sodium excretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    prepulse inhibition IEA
    Inferred from Electronic Annotation
    more info
     
    prepulse inhibition ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of blood volume by renin-angiotensin IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of blood volume by renin-angiotensin ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cAMP metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of cAMP metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of circadian sleep/wake cycle, sleep IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of dopamine secretion IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of dopamine secretion ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of lipid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of locomotion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of locomotion involved in locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of multicellular organism growth IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of multicellular organism growth ISO
    Inferred from Sequence Orthology
    more info
     
    response to amphetamine IEA
    Inferred from Electronic Annotation
    more info
     
    response to amphetamine ISO
    Inferred from Sequence Orthology
    more info
     
    response to cocaine ISO
    Inferred from Sequence Orthology
    more info
     
    response to drug IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to drug TAS
    Traceable Author Statement
    more info
    PubMed 
    response to ethanol IEA
    Inferred from Electronic Annotation
    more info
     
    response to ethanol ISO
    Inferred from Sequence Orthology
    more info
     
    NOT response to ethanol ISO
    Inferred from Sequence Orthology
    more info
     
    response to histamine IEA
    Inferred from Electronic Annotation
    more info
     
    response to histamine ISO
    Inferred from Sequence Orthology
    more info
     
    response to morphine IEA
    Inferred from Electronic Annotation
    more info
     
    response to morphine ISO
    Inferred from Sequence Orthology
    more info
     
    synaptic transmission, dopaminergic IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    visual learning IEA
    Inferred from Electronic Annotation
    more info
     
    visual learning ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    apical part of cell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endocytic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    D(3) dopamine receptor
    Names
    dopamine D3 receptor isoform
    dopaminergic receptor D3

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017140.2NP_058836.1  D(3) dopamine receptor

      See identical proteins and their annotated locations for NP_058836.1

      Status: VALIDATED

      Source sequence(s)
      AABR07072236, AC114526
      UniProtKB/Swiss-Prot
      P19020
      Related
      ENSRNOP00000073117.1, ENSRNOT00000089057.1
      Conserved Domains (2) summary
      pfam00001
      Location:46429
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:44225
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005110.4 Reference Rnor_6.0 Primary Assembly

      Range
      61819102..61883223 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006248313.3XP_006248375.2  D(3) dopamine receptor isoform X1

      Conserved Domains (2) summary
      pfam00001
      Location:78461
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:76257
      7tm_4; Olfactory receptor

    Alternate Rn_Celera

    Genomic

    1. AC_000079.1 Alternate Rn_Celera

      Range
      56432639..56484538 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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