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    Eno2 enolase 2, gamma, neuronal [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24334, updated on 26-Sep-2017
    Official Symbol
    Eno2provided by RGD
    Official Full Name
    enolase 2, gamma, neuronalprovided by RGD
    Primary source
    RGD:2554
    See related
    Ensembl:ENSRNOG00000013141
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    NSE; RNEN3
    Summary
    catalyzes the interconversion of 2-phosphoglycerate to phosphoenolpyruvate; may play a role in glycolysis [RGD, Feb 2006]
    Orthologs
    Location:
    4q42
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (157285192..157294090, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 4 NC_005103.3 (224302788..224311673, complement)

    Chromosome 4 - NC_005103.4Genomic Context describing neighboring genes Neighboring gene gene rich cluster, C10 gene Neighboring gene uncharacterized LOC102553919 Neighboring gene atrophin 1 Neighboring gene leucine rich repeat containing 23 Neighboring gene splA/ryanodine receptor domain and SOCS box containing 2 Neighboring gene triosephosphate isomerase 1

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    phosphopyruvate hydratase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phosphopyruvate hydratase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    protein heterodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    canonical glycolysis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    gluconeogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    glycolytic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    multicellular organismal reproductive process IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    negative regulation of neuron death IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein heterotetramerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of neuron death IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    response to drug IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to estradiol IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to organic cyclic compound IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    cell cortex region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    growth cone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intracellular ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    membrane raft IDA
    Inferred from Direct Assay
    more info
    PubMed 
    myelin sheath ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    neuron projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    perikaryon ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    phosphopyruvate hydratase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    photoreceptor inner segment ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    synaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    gamma-enolase
    Names
    2-phospho-D-glycerate hydro-lyase
    neural enolase
    neuron-specific enolase
    NP_647541.1
    XP_006237392.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_139325.4NP_647541.1  gamma-enolase

      See identical proteins and their annotated locations for NP_647541.1

      Status: VALIDATED

      Source sequence(s)
      AC129138, CB615520
      UniProtKB/Swiss-Prot
      P07323
      Related
      ENSRNOP00000005601.3, ENSRNOT00000005601.4
      Conserved Domains (2) summary
      PLN00191
      Location:2432
      PLN00191; enolase
      cd03313
      Location:5416
      enolase; Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions.

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005103.4 Reference Rnor_6.0 Primary Assembly

      Range
      157285192..157294090 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006237330.3XP_006237392.1  gamma-enolase isoform X1

      See identical proteins and their annotated locations for XP_006237392.1

      UniProtKB/Swiss-Prot
      P07323
      Conserved Domains (2) summary
      PLN00191
      Location:2432
      PLN00191; enolase
      cd03313
      Location:5416
      enolase; Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions.

    Alternate Rn_Celera

    Genomic

    1. AC_000072.1 Alternate Rn_Celera

      Range
      146310173..146318990 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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