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    PTP4A3 protein tyrosine phosphatase type IVA, member 3 [ Homo sapiens (human) ]

    Gene ID: 11156, updated on 19-Mar-2017
    Official Symbol
    PTP4A3provided by HGNC
    Official Full Name
    protein tyrosine phosphatase type IVA, member 3provided by HGNC
    Primary source
    HGNC:HGNC:9636
    See related
    Ensembl:ENSG00000184489 MIM:606449; Vega:OTTHUMG00000164490
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PRL3; PRL-3; PRL-R
    Summary
    This gene encodes a member of the protein-tyrosine phosphatase family. Protein tyrosine phosphatases are cell signaling molecules that play regulatory roles in a variety of cellular processes. Studies of this class of protein tyrosine phosphatase in mice demonstrates that they are prenylated in vivo, suggesting their association with cell plasma membrane. The encoded protein may enhance cell proliferation, and overexpression of this gene has been implicated in tumor metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
    Orthologs
    Location:
    8q24.3
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 8 NC_000008.11 (141391993..141432454)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (142402093..142442554)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101928037 Neighboring gene uncharacterized LOC105375790 Neighboring gene uncharacterized LOC107983985 Neighboring gene uncharacterized LOC105375789 Neighboring gene maestro heat like repeat family member 5 Neighboring gene heterogeneous nuclear ribonucleoprotein A1pseudogene 38

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    prenylated protein tyrosine phosphatase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein tyrosine/serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    Notch signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    endothelial cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    peptidyl-tyrosine dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of NIK/NF-kappaB signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of establishment of protein localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of vascular permeability IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of vascular endothelial growth factor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cytoplasm IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    early endosome IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    protein tyrosine phosphatase type IVA 3
    Names
    potentially prenylated protein tyrosine phosphatase
    protein-tyrosine phosphatase 4a3
    protein-tyrosine phosphatase of regenerating liver 3
    NP_009010.2
    NP_116000.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007079.3NP_009010.2  protein tyrosine phosphatase type IVA 3 isoform 2

      See identical proteins and their annotated locations for NP_009010.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
      Source sequence(s)
      AC100803, AK311257, BC003105
      Consensus CDS
      CCDS6382.1
      UniProtKB/Swiss-Prot
      O75365
      Related
      ENSP00000331730, ENST00000349124
      Conserved Domains (1) summary
      cl21483
      Location:11148
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    2. NM_032611.2NP_116000.1  protein tyrosine phosphatase type IVA 3 isoform 1

      See identical proteins and their annotated locations for NP_116000.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC100803, AK311257, BC003105, BQ637038
      Consensus CDS
      CCDS6383.1
      UniProtKB/Swiss-Prot
      O75365
      Related
      ENSP00000332274, ENST00000329397
      Conserved Domains (1) summary
      cl21483
      Location:11173
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p7 Primary Assembly

      Range
      141391993..141432454
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017012998.1XP_016868487.1  protein tyrosine phosphatase type IVA 3 isoform X3

      UniProtKB/Swiss-Prot
      O75365
      Related
      ENSP00000428758, OTTHUMP00000226812, ENST00000520105, OTTHUMT00000378978
      Conserved Domains (1) summary
      cl21483
      Location:11148
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    2. XM_006716500.2XP_006716563.1  protein tyrosine phosphatase type IVA 3 isoform X2

      See identical proteins and their annotated locations for XP_006716563.1

      Conserved Domains (1) summary
      cl21483
      Location:5149
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    3. XM_017012999.1XP_016868488.1  protein tyrosine phosphatase type IVA 3 isoform X4

    4. XM_011516805.1XP_011515107.1  protein tyrosine phosphatase type IVA 3 isoform X1

      See identical proteins and their annotated locations for XP_011515107.1

      UniProtKB/Swiss-Prot
      O75365
      Conserved Domains (1) summary
      cl21483
      Location:11173
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    5. XM_011516803.1XP_011515105.1  protein tyrosine phosphatase type IVA 3 isoform X1

      See identical proteins and their annotated locations for XP_011515105.1

      UniProtKB/Swiss-Prot
      O75365
      Conserved Domains (1) summary
      cl21483
      Location:11173
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    6. XM_005250764.2XP_005250821.1  protein tyrosine phosphatase type IVA 3 isoform X1

      See identical proteins and their annotated locations for XP_005250821.1

      UniProtKB/Swiss-Prot
      O75365
      Conserved Domains (1) summary
      cl21483
      Location:11173
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

    Reference GRCh38.p7 ALT_REF_LOCI_1

    Genomic

    1. NT_187574.1 Reference GRCh38.p7 ALT_REF_LOCI_1

      Range
      93844..104910
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018919.2 Alternate CHM1_1.1

      Range
      142471719..142482782
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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