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    Itgav integrin alpha V [ Mus musculus (house mouse) ]

    Gene ID: 16410, updated on 2-May-2017
    Official Symbol
    Itgavprovided by MGI
    Official Full Name
    integrin alpha Vprovided by MGI
    Primary source
    MGI:MGI:96608
    See related
    Ensembl:ENSMUSG00000027087 Vega:OTTMUSG00000013360
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CD51; 1110004F14Rik; 2610028E01Rik; D430040G12Rik
    Summary
    This gene encodes a protein that is a member of the integrin superfamily. Integrins are transmembrane receptors involved cell adhesion and signaling, and they are subdivided based on the heterodimer formation of alpha and beta chains. This protein has been shown to heterodimerize with beta 1, beta 3, beta 6 and beta 8. The heterodimer of alpha v and beta 3 forms the Vitronectin receptor. This protein interacts with several extracellular matrix proteins to mediate cell adhesion and may play a role in cell migration. In mouse, deficiency of this gene is associated with defects in vascular morphogenesis in the brain and early post-natal death. [provided by RefSeq, May 2013]
    Orthologs
    Location:
    2 D; 2 49.33 cM
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (83724108..83806917)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (83564554..83647073)

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 54, member A pseudogene Neighboring gene zinc finger CCCH-type containing 15 Neighboring gene DNA methyltransferase 3-like, pseudogene 1 Neighboring gene family with sequence similarity 171, member B Neighboring gene zinc finger SWIM-type containing 2

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    contributes_to C-X3-C chemokine binding ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular matrix binding ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular matrix protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to fibroblast growth factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    fibronectin binding ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to insulin-like growth factor I binding ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to neuregulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to opsonin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    peptide binding ISO
    Inferred from Sequence Orthology
    more info
     
    protease binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein heterodimerization activity TAS
    Traceable Author Statement
    more info
    PubMed 
    contributes_to protein kinase C binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    voltage-gated calcium channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    ERK1 and ERK2 cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    T cell activation TAS
    Traceable Author Statement
    more info
    PubMed 
    angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    apolipoprotein A-I-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    apoptotic cell clearance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    blood vessel development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    calcium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    cell adhesion mediated by integrin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell adhesion mediated by integrin ISO
    Inferred from Sequence Orthology
    more info
     
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    cell-matrix adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    cell-matrix adhesion TAS
    Traceable Author Statement
    more info
    PubMed 
    cell-substrate adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    cellular calcium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    detection of molecule of bacterial origin TAS
    Traceable Author Statement
    more info
    PubMed 
    endodermal cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    endothelial cell migration TAS
    Traceable Author Statement
    more info
    PubMed 
    extrinsic apoptotic signaling pathway in absence of ligand IDA
    Inferred from Direct Assay
    more info
    PubMed 
    fertilization NAS
    Non-traceable Author Statement
    more info
    PubMed 
    focal adhesion assembly NAS
    Non-traceable Author Statement
    more info
    PubMed 
    gonad morphogenesis NAS
    Non-traceable Author Statement
    more info
    PubMed 
    heterotypic cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    inflammatory response TAS
    Traceable Author Statement
    more info
    PubMed 
    integrin-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    negative chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of entry of bacterium into host cell ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of extrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of lipid storage ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of lipid transport ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of lipoprotein metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of low-density lipoprotein particle receptor biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of macrophage derived foam cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of osteoblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of apoptotic cell clearance IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of bone resorption TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of phagocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of phagocytosis NAS
    Non-traceable Author Statement
    more info
    PubMed 
    release of sequestered calcium ion into cytosol TAS
    Traceable Author Statement
    more info
    PubMed 
    response to nitric oxide TAS
    Traceable Author Statement
    more info
    PubMed 
    substrate adhesion-dependent cell spreading ISO
    Inferred from Sequence Orthology
    more info
     
    transforming growth factor-beta secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    trophoblast giant cell differentiation TAS
    Traceable Author Statement
    more info
    PubMed 
    viral entry into host cell ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    alphav-beta3 integrin-IGF-1-IGF1R complex ISO
    Inferred from Sequence Orthology
    more info
     
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    filopodium membrane ISO
    Inferred from Sequence Orthology
    more info
     
    focal adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integrin alphav-beta3 complex ISO
    Inferred from Sequence Orthology
    more info
     
    integrin alphav-beta3 complex TAS
    Traceable Author Statement
    more info
    PubMed 
    integrin alphav-beta5 complex ISO
    Inferred from Sequence Orthology
    more info
     
    integrin alphav-beta6 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integrin alphav-beta8 complex ISO
    Inferred from Sequence Orthology
    more info
     
    integrin complex ISO
    Inferred from Sequence Orthology
    more info
     
    lamellipodium membrane ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    microvillus membrane ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    ruffle membrane ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    integrin alpha-V
    Names
    alpha v integrin
    vitronectin receptor alpha polypeptide (VNRA)
    vitronectin receptor subunit alpha

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008402.3NP_032428.2  integrin alpha-V precursor

      See identical proteins and their annotated locations for NP_032428.2

      Status: REVIEWED

      Source sequence(s)
      AK149984, AL772301
      Consensus CDS
      CCDS16181.1
      UniProtKB/Swiss-Prot
      P43406
      Related
      ENSMUSP00000028499.4, OTTMUSP00000014341, ENSMUST00000028499.10, OTTMUST00000032292
      Conserved Domains (3) summary
      smart00191
      Location:367421
      Int_alpha; Integrin alpha (beta-propellor repeats)
      pfam08441
      Location:467910
      Integrin_alpha2; Integrin alpha
      sd00039
      Location:126183
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

      Range
      83724108..83806917
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006498807.3XP_006498870.1  integrin alpha-V isoform X1

      Conserved Domains (3) summary
      smart00191
      Location:366420
      Int_alpha; Integrin alpha (beta-propellor repeats)
      pfam08441
      Location:466909
      Integrin_alpha2; Integrin alpha
      sd00039
      Location:125182
      7WD40; WD40 repeat [structural motif]
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