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    aak-2 5'-AMP-activated protein kinase catalytic subunit alpha-2 [ Caenorhabditis elegans ]

    Gene ID: 181727, updated on 22-May-2018
    Gene symbol
    aak-2
    Gene description
    5'-AMP-activated protein kinase catalytic subunit alpha-2
    Primary source
    WormBase:WBGene00020142
    Locus tag
    CELE_T01C8.1
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    See aak-2 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    10
    Sequence:
    Chromosome: X; NC_003284.9 (16796089..16802850)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Probable aspartate aminotransferase, cytoplasmic Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Degenerin mec-4 Neighboring gene Adenylyl cyclase-associated protein

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    AMP-activated protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cellular response to glucose starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    gonad morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    histone-serine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of TOR signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of dauer larval development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleotide-activated protein kinase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Preferred Names
    5'-AMP-activated protein kinase catalytic subunit alpha-2
    NP_001024868.1
    • Confirmed by transcript evidence
    NP_510710.2
    • Confirmed by transcript evidence
    NP_510711.2
    • Confirmed by transcript evidence

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      16796089..16802850
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078309.4NP_510710.2  5'-AMP-activated protein kinase catalytic subunit alpha-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_510710.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q95ZQ4
      Conserved Domains (4) summary
      cd12122
      Location:462624
      AMPKA_C; C-terminal regulatory domain of 5'-AMP-activated protein kinase (AMPK) alpha catalytic subunit
      smart00220
      Location:87339
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14336
      Location:356419
      UBA_AID_AMPKalpha; UBA-like autoinhibitory domain (AID) found in vertebrate 5'-AMP-activated protein kinase catalytic alpha (AMPKalpha) subunits
      cd14079
      Location:84339
      STKc_AMPK_alpha; Catalytic domain of the Alpha subunit of the Serine/Threonine Kinase, AMP-activated protein kinase
    2. NM_078310.5NP_510711.2  5'-AMP-activated protein kinase catalytic subunit alpha-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_510711.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q95ZQ4
      Conserved Domains (4) summary
      cd12122
      Location:460622
      AMPKA_C; C-terminal regulatory domain of 5'-AMP-activated protein kinase (AMPK) alpha catalytic subunit
      smart00220
      Location:87339
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14336
      Location:356417
      UBA_AID_AMPKalpha; UBA-like autoinhibitory domain (AID) found in vertebrate 5'-AMP-activated protein kinase catalytic alpha (AMPKalpha) subunits
      cd14079
      Location:84339
      STKc_AMPK_alpha; Catalytic domain of the Alpha subunit of the Serine/Threonine Kinase, AMP-activated protein kinase
    3. NM_001029697.3NP_001024868.1  5'-AMP-activated protein kinase catalytic subunit alpha-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024868.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q95ZQ4
      Conserved Domains (4) summary
      cd12122
      Location:398560
      AMPKA_C; C-terminal regulatory domain of 5'-AMP-activated protein kinase (AMPK) alpha catalytic subunit
      smart00220
      Location:25277
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14336
      Location:294355
      UBA_AID_AMPKalpha; UBA-like autoinhibitory domain (AID) found in vertebrate 5'-AMP-activated protein kinase catalytic alpha (AMPKalpha) subunits
      cd14079
      Location:22277
      STKc_AMPK_alpha; Catalytic domain of the Alpha subunit of the Serine/Threonine Kinase, AMP-activated protein kinase
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