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    CEACAM3 carcinoembryonic antigen related cell adhesion molecule 3 [ Homo sapiens (human) ]

    Gene ID: 1084, updated on 6-Sep-2017
    Official Symbol
    CEACAM3provided by HGNC
    Official Full Name
    carcinoembryonic antigen related cell adhesion molecule 3provided by HGNC
    Primary source
    HGNC:HGNC:1815
    See related
    Ensembl:ENSG00000170956 MIM:609142; Vega:OTTHUMG00000150142
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CEA; CGM1; W264; W282; CD66D
    Summary
    This gene encodes a member of the family of carcinoembryonic antigen-related cell adhesion molecules (CEACAMs), which are used by several bacterial pathogens to bind and invade host cells. The encoded transmembrane protein directs phagocytosis of several bacterial species that is dependent on the small GTPase Rac. It is thought to serve an important role in controlling human-specific pathogens by the innate immune system. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2013]
    Expression
    Biased expression in bone marrow (RPKM 11.7), appendix (RPKM 5.0) and 3 other tissues See more
    Orthologs
    Location:
    19q13.2
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 19 NC_000019.10 (41796590..41811553)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (42300522..42315591)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene carcinoembryonic antigen related cell adhesion molecule 5 Neighboring gene carcinoembryonic antigen related cell adhesion molecule 6 Neighboring gene carcinoembryonic antigen related cell adhesion molecule 1 pseudogene Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 52 Neighboring gene LY6/PLAUR domain containing 4 Neighboring gene DMRT like family C2

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Cell surface interactions at the vascular wall, organism-specific biosystem (from REACTOME)
      Cell surface interactions at the vascular wall, organism-specific biosystemLeukocyte extravasation is a rigorously controlled process that guides white cell movement from the vascular lumen to sites of tissue inflammation. The powerful adhesive interactions that are require...
    • Hemostasis, organism-specific biosystem (from REACTOME)
      Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Innate Immune System, organism-specific biosystem (from REACTOME)
      Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
    • Neutrophil degranulation, organism-specific biosystem (from REACTOME)
      Neutrophil degranulation, organism-specific biosystemNeutrophils are the most abundant leukocytes (white blood cells), indispensable in defending the body against invading microorganisms. In response to infection, neutrophils leave the circulation and ...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ51937, MGC119875

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    leukocyte migration TAS
    Traceable Author Statement
    more info
     
    neutrophil degranulation TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    specific granule membrane TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    carcinoembryonic antigen-related cell adhesion molecule 3
    Names
    CD66d antigen
    carcinoembryonic antigen CGM1
    carcinoembryonic antigen gene family member 1
    nonspecific cross-reacting antigen

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001277163.2NP_001264092.1  carcinoembryonic antigen-related cell adhesion molecule 3 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001264092.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate coding exon and has an alternate splice site in the 3' region, compared to variant 1. The resulting isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC243967, D90277, D90278, DC428993, L00693
      Consensus CDS
      CCDS62685.1
      UniProtKB/Swiss-Prot
      P40198
      Related
      ENSP00000341725.4, OTTHUMP00000196409, ENST00000344550.4, OTTHUMT00000316510
      Conserved Domains (1) summary
      cd05774
      Location:36140
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    2. NM_001815.4NP_001806.2  carcinoembryonic antigen-related cell adhesion molecule 3 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001806.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC243967, BC106728, D90277, D90278, DC428993
      Consensus CDS
      CCDS12586.2
      UniProtKB/Swiss-Prot
      P40198
      Related
      ENSP00000349971.3, OTTHUMP00000196408, ENST00000357396.7, OTTHUMT00000316509
      Conserved Domains (1) summary
      cd05774
      Location:36140
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)

    RNA

    1. NR_102333.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) has an additional exon in the central region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC243967, D90277, D90278, DC428993
      Related
      ENST00000415495.5, OTTHUMT00000316511

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p7 Primary Assembly

      Range
      41796590..41811553
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018930.2 Alternate CHM1_1.1

      Range
      42302125..42317088
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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