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    Msln mesothelin [ Rattus norvegicus (Norway rat) ]

    Gene ID: 60333, updated on 12-Mar-2017
    Official Symbol
    Mslnprovided by RGD
    Official Full Name
    mesothelinprovided by RGD
    Primary source
    RGD:69333
    See related
    Ensembl:ENSRNOG00000019445
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    may play a role in cell adhesion and cell shape dynamics; human homolog highly expressed in renal cell carcinoma [RGD, Feb 2006]
    Location:
    10q12
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (15119700..15129129, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 10 NC_005109.3 (14932441..14941855, complement)

    Chromosome 10 - NC_005109.4Genomic Context describing neighboring genes Neighboring gene RNA pseudouridylate synthase domain containing 1 Neighboring gene mesothelin-like Neighboring gene nuclear prelamin A recognition factor-like Neighboring gene hydroxyacylglutathione hydrolase-like Neighboring gene coiled-coil domain containing 78

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    cell-matrix adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    pancreas development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    anchored component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    mesothelin
    Names
    ERC/mesothelin
    pre-pro-megakaryocyte-potentiating factor
    protein expressed in renal carcinoma

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031658.1NP_113846.1  mesothelin precursor

      See identical proteins and their annotated locations for NP_113846.1

      Status: PROVISIONAL

      Source sequence(s)
      D87351
      UniProtKB/Swiss-Prot
      Q9ERA7
      Related
      ENSRNOP00000026395, ENSRNOT00000026395
      Conserved Domains (1) summary
      pfam06060
      Location:1624
      Mesothelin; Pre-pro-megakaryocyte potentiating factor precursor (Mesothelin)

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005109.4 Reference Rnor_6.0 Primary Assembly

      Range
      15119700..15129129 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006246022.2XP_006246084.1  mesothelin isoform X1

      See identical proteins and their annotated locations for XP_006246084.1

      UniProtKB/Swiss-Prot
      Q9ERA7
      Conserved Domains (1) summary
      pfam06060
      Location:1624
      Mesothelin; Pre-pro-megakaryocyte potentiating factor precursor (Mesothelin)
    2. XM_006246021.3XP_006246083.1  mesothelin isoform X1

      See identical proteins and their annotated locations for XP_006246083.1

      UniProtKB/Swiss-Prot
      Q9ERA7
      Conserved Domains (1) summary
      pfam06060
      Location:1624
      Mesothelin; Pre-pro-megakaryocyte potentiating factor precursor (Mesothelin)

    Alternate Rn_Celera

    Genomic

    1. AC_000078.1 Alternate Rn_Celera

      Range
      14441324..14446985 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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