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    mutS methyl-directed mismatch repair protein [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947206, updated on 22-May-2018
    Gene symbol
    mutS
    Gene description
    methyl-directed mismatch repair protein
    Primary source
    EcoGene:EG10625
    Locus tag
    b2733
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ant; ECK2728; fdv; JW2703; plm
    Summary
    MutS has weak ATPase activity and may be involved in recognizing the DNA mismatch. [More information is available at EcoGene: EG10625]. MutS is one of the components of the MutHLS complex. [More information is available at EcoCyc: EG10625].
    Sequence:
    NC_000913.3 (2857093..2859654)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene formate hydrogenlyase transcriptional activator Neighboring gene uncharacterized protein Neighboring gene serine/threonine-specific protein phosphatase 2 Neighboring gene DeoR family putative transcriptional regulator

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Mismatch repair, organism-specific biosystem (from KEGG)
      Mismatch repair, organism-specific biosystemDNA mismatch repair (MMR) is a highly conserved biological pathway that plays a key role in maintaining genomic stability. MMR corrects DNA mismatches generated during DNA replication, thereby preven...
    • Mismatch repair, conserved biosystem (from KEGG)
      Mismatch repair, conserved biosystemDNA mismatch repair (MMR) is a highly conserved biological pathway that plays a key role in maintaining genomic stability. MMR corrects DNA mismatches generated during DNA replication, thereby preven...
    Products Interactant Other Gene Complex Source Pubs Description

    Gene Ontology Provided by GO

    Function Evidence Code Pubs
    ADP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ADP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ATP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ATP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    ATPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA binding, bending IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    DNA binding, bending IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA-dependent ATPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    adenine/cytosine mispair binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    adenine/cytosine mispair binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    damaged DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    identical protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    mismatched DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mismatched DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mismatched DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    cellular response to DNA damage stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    mismatch repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mismatch repair IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mismatch repair IEA
    Inferred from Electronic Annotation
    more info
     
    mismatch repair IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of DNA recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of DNA recombination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mismatch repair complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mismatch repair complex IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Names
    methyl-directed mismatch repair protein
    NP_417213.1
    • methyl-directed mismatch repair

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2857093..2859654
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417213.1 methyl-directed mismatch repair protein [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417213.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P23909
      Conserved Domains (1) summary
      PRK05399
      Location:3853
      PRK05399; DNA mismatch repair protein MutS; Provisional
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