Format

Send to:

Choose Destination

Links from PubMed

    • Showing Current items.

    Ghrl ghrelin and obestatin prepropeptide [ Rattus norvegicus (Norway rat) ]

    Gene ID: 59301, updated on 17-Sep-2017
    Official Symbol
    Ghrlprovided by RGD
    Official Full Name
    ghrelin and obestatin prepropeptideprovided by RGD
    Primary source
    RGD:632283
    See related
    Ensembl:ENSRNOG00000010349
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    endogenous ligand for the growth hormone secretagogue receptor (GHSR); involved in testicular function and GH release [RGD, Feb 2006]
    Orthologs
    Location:
    4q42
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (145674157..145678066, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 4 NC_005103.3 (208969963..208976778, complement)

    Chromosome 4 - NC_005103.4Genomic Context describing neighboring genes Neighboring gene interleukin-1 receptor-associated kinase 2 Neighboring gene TatD DNase domain containing 2 Neighboring gene SEC13 homolog, nuclear pore and COPII coat complex component Neighboring gene ATPase plasma membrane Ca2+ transporting 2

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    G-protein coupled receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ghrelin receptor binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    growth hormone-releasing hormone activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    hormone activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein tyrosine kinase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein tyrosine kinase activator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    G-protein coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    actin polymerization or depolymerization ISO
    Inferred from Sequence Orthology
    more info
     
    actin polymerization or depolymerization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    activation of MAPK activity ISO
    Inferred from Sequence Orthology
    more info
     
    activation of MAPK activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    adult feeding behavior ISO
    Inferred from Sequence Orthology
    more info
     
    adult feeding behavior ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    decidualization ISO
    Inferred from Sequence Orthology
    more info
     
    decidualization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    dendrite development IEA
    Inferred from Electronic Annotation
    more info
     
    dendrite development ISO
    Inferred from Sequence Orthology
    more info
     
    excitatory postsynaptic potential IEA
    Inferred from Electronic Annotation
    more info
     
    excitatory postsynaptic potential ISO
    Inferred from Sequence Orthology
    more info
     
    gastric acid secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    gastric emptying IDA
    Inferred from Direct Assay
    more info
    PubMed 
    hormone-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    negative regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of circadian sleep/wake cycle, REM sleep IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of circadian sleep/wake cycle, REM sleep ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of endothelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of endothelial cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of energy homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of energy homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    negative regulation of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of inflammatory response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of insulin secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of insulin secretion ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of interleukin-1 beta production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of interleukin-1 beta production ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of interleukin-1 beta production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of interleukin-6 biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of interleukin-6 biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of locomotion IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of locomotion ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of tumor necrosis factor biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of tumor necrosis factor biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of tumor necrosis factor secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of adipose tissue development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of appetite IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of appetite ISO
    Inferred from Sequence Orthology
    more info
     
    NOT positive regulation of appetite ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of appetite ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of bone development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of circadian sleep/wake cycle, non-REM sleep IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of circadian sleep/wake cycle, non-REM sleep ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of corticotropin secretion IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of corticotropin secretion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cortisol secretion IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cortisol secretion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cytosolic calcium ion concentration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of eating behavior IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of energy homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of energy homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of feeding behavior IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of gastric mucosal blood circulation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of gastro-intestinal system smooth muscle contraction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of growth IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of growth hormone secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of growth hormone secretion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of growth rate IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of insulin secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of insulin secretion involved in cellular response to glucose stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    positive regulation of response to food IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of small intestinal transit IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of small intestine smooth muscle contraction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of sprouting angiogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of synapse assembly IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of synapse assembly ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of vascular endothelial cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of gastric motility IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of response to food IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of transmission of nerve impulse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to electrical stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to estrogen ISO
    Inferred from Sequence Orthology
    more info
     
    response to estrogen ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    response to hormone ISO
    Inferred from Sequence Orthology
    more info
     
    response to hormone ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    response to nutrient levels IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    axon ISO
    Inferred from Sequence Orthology
    more info
     
    axon ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular region ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular region ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    extracellular region TAS
    Traceable Author Statement
    more info
     
    extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    extracellular space IC
    Inferred by Curator
    more info
    PubMed 
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular space ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    postsynapse IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    appetite-regulating hormone
    Names
    ghrelin/obestatin prepropeptide
    growth hormone secretagogue
    growth hormone-releasing peptide
    motilin-related peptide

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021669.2NP_067701.1  appetite-regulating hormone preproprotein

      See identical proteins and their annotated locations for NP_067701.1

      Status: VALIDATED

      Source sequence(s)
      AB029433, BF543543
      UniProtKB/Swiss-Prot
      Q9QYH7
      Related
      ENSRNOP00000014103.1, ENSRNOT00000014103.1
      Conserved Domains (2) summary
      pfam04643
      Location:57115
      Motilin_assoc; Motilin/ghrelin-associated peptide
      pfam04644
      Location:2551
      Motilin_ghrelin; Motilin/ghrelin

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005103.4 Reference Rnor_6.0 Primary Assembly

      Range
      145674157..145678066 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000072.1 Alternate Rn_Celera

      Range
      135420041..135423946 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center