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    Erbb4 erb-b2 receptor tyrosine kinase 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 59323, updated on 5-Nov-2017
    Official Symbol
    Erbb4provided by RGD
    Official Full Name
    erb-b2 receptor tyrosine kinase 4provided by RGD
    Primary source
    RGD:620486
    See related
    Ensembl:ENSRNOG00000014248
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    binds neuregulins; involved in epithelial-mesenchymal interactions during development; may play a role in tooth morphogenesis [RGD, Feb 2006]
    Expression
    Biased expression in Brain (RPKM 139.1), Kidney (RPKM 128.9) and 5 other tissues See more
    Orthologs
    Location:
    9q32-q33
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (75021790..76178936, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 9 NC_005108.3 (74804287..75310350, complement)

    Chromosome 9 - NC_005108.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103690552 Neighboring gene carbamoyl-phosphate synthase 1 Neighboring gene 40S ribosomal protein S10 pseudogene Neighboring gene similar to chromosome 20 open reading frame 81 Neighboring gene IKAROS family zinc finger 2

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    epidermal growth factor receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    epidermal growth factor receptor binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    signal transducer, downstream of receptor, with protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    transcription regulatory region DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    transcription regulatory region DNA binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    transmembrane receptor protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    transmembrane receptor protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    transmembrane receptor protein tyrosine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    cardiac muscle tissue regeneration IEA
    Inferred from Electronic Annotation
    more info
     
    cardiac muscle tissue regeneration ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cardiac muscle tissue regeneration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cell fate commitment IEA
    Inferred from Electronic Annotation
    more info
     
    cell fate commitment ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cell migration ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cellular response to epidermal growth factor stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to epidermal growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    central nervous system morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    central nervous system morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    central nervous system morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    embryonic pattern specification IEA
    Inferred from Electronic Annotation
    more info
     
    embryonic pattern specification ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    embryonic pattern specification ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    heart development IEA
    Inferred from Electronic Annotation
    more info
     
    heart development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    heart development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    lactation IEA
    Inferred from Electronic Annotation
    more info
     
    lactation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    lactation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    mammary gland alveolus development IEA
    Inferred from Electronic Annotation
    more info
     
    mammary gland alveolus development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    mammary gland alveolus development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    mammary gland development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    mammary gland epithelial cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    mammary gland epithelial cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    mammary gland epithelial cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    mitochondrial fragmentation involved in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrial fragmentation involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    mitochondrial fragmentation involved in apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of muscle cell apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of neuron migration IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of neuron migration ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    nervous system development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    nervous system development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    neural crest cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    neural crest cell migration ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    neural crest cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    odontogenesis IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    odontogenesis NAS
    Non-traceable Author Statement
    more info
    PubMed 
    olfactory bulb interneuron differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    olfactory bulb interneuron differentiation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    olfactory bulb interneuron differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    peptidyl-tyrosine autophosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    peptidyl-tyrosine autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    peptidyl-tyrosine phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of ERK1 and ERK2 cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of STAT protein import into nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of STAT protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of STAT protein import into nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of cardiac muscle cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cardiac muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of cardiac muscle cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    NOT positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of epithelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of glucose import IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of phosphatidylinositol 3-kinase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    NOT positive regulation of phosphatidylinositol 3-kinase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of phosphatidylinositol 3-kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of phosphatidylinositol 3-kinase signaling IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of phosphatidylinositol 3-kinase signaling ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of protein localization to cell surface IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of protein localization to cell surface ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of synaptic transmission, GABAergic IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of transcription, DNA-templated ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of tyrosine phosphorylation of STAT protein IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of tyrosine phosphorylation of STAT protein ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of tyrosine phosphorylation of STAT protein ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein autophosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    response to drug IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to hydrogen peroxide IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to progesterone IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    signal transduction ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    signal transduction by protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    surfactant homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    synapse maturation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    telencephalon development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    transmembrane receptor protein tyrosine kinase signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    transmembrane receptor protein tyrosine kinase signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    transmembrane receptor protein tyrosine kinase signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    transmembrane receptor protein tyrosine kinase signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    basolateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    caveola IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane raft IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    postsynaptic density IDA
    Inferred from Direct Assay
    more info
    PubMed 
    receptor complex IEA
    Inferred from Electronic Annotation
    more info
     
    receptor complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Preferred Names
    receptor tyrosine-protein kinase erbB-4
    Names
    c-erbB-4
    proto-oncogene-like protein c-ErbB-4
    receptor tyrosine kinase
    v-erb-a erythroblastic leukemia viral oncogene homolog 4
    v-erb-b2 avian erythroblastic leukemia viral oncogene 4
    NP_067719.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021687.1NP_067719.1  receptor tyrosine-protein kinase erbB-4 precursor

      See identical proteins and their annotated locations for NP_067719.1

      Status: PROVISIONAL

      Source sequence(s)
      AF041838
      UniProtKB/Swiss-Prot
      Q62956
      Related
      ENSRNOP00000019283.5, ENSRNOT00000019283.6
      Conserved Domains (8) summary
      cd05110
      Location:7101012
      PTKc_HER4; Catalytic domain of the Protein Tyrosine Kinase, HER4
      cd12092
      Location:642685
      TM_ErbB4; Transmembrane domain of ErbB4, a Protein Tyrosine Kinase
      smart00261
      Location:549595
      FU; Furin-like repeats
      cd00064
      Location:229274
      FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
      pfam00757
      Location:186332
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:55167
      Recep_L_domain; Receptor L domain
      pfam07714
      Location:718974
      Pkinase_Tyr; Protein tyrosine kinase
      pfam14843
      Location:502634
      GF_recep_IV; Growth factor receptor domain IV

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005108.4 Reference Rnor_6.0 Primary Assembly

      Range
      75021790..76178936 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000077.1 Alternate Rn_Celera

      Range
      67006553..68064842 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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