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    Was Wiskott-Aldrich syndrome [ Mus musculus (house mouse) ]

    Gene ID: 22376, updated on 25-May-2017
    Official Symbol
    Wasprovided by MGI
    Official Full Name
    Wiskott-Aldrich syndromeprovided by MGI
    Primary source
    MGI:MGI:105059
    See related
    Ensembl:ENSMUSG00000031165 Vega:OTTMUSG00000018093
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Wasp; U42471
    Orthologs
    Location:
    X A1.1; X 3.65 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) X NC_000086.7 (8081466..8090491, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (7658592..7667617, complement)

    Chromosome X - NC_000086.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein S29 pseudogene Neighboring gene suppressor of variegation 3-9 homolog 1 (Drosophila) Neighboring gene proteasome (prosome, macropain) subunit, beta type 7 pseudogene Neighboring gene proteasome (prosome, macropain) subunit, beta type 7, pseudogene 2 Neighboring gene WD repeat domain 13

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    Rac GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    SH3 domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    identical protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    phospholipase binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    Cdc42 protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    T cell activation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    actin filament organization IEA
    Inferred from Electronic Annotation
    more info
     
    actin filament polymerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    actin filament-based movement IDA
    Inferred from Direct Assay
    more info
    PubMed 
    actin polymerization or depolymerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endosomal transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    immune response ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell motility ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of stress fiber assembly ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of Arp2/3 complex-mediated actin nucleation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of T cell antigen processing and presentation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of actin polymerization or depolymerization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of lamellipodium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of stress fiber assembly ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    actin filament ISO
    Inferred from Sequence Orthology
    more info
     
    cell-cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    vesicle membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    wiskott-Aldrich syndrome protein homolog
    Names
    Wiskott-Aldrich syndrome homolog

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009515.2NP_033541.1  wiskott-Aldrich syndrome protein homolog

      See identical proteins and their annotated locations for NP_033541.1

      Status: VALIDATED

      Source sequence(s)
      BY232461, CJ237505, U29673
      Consensus CDS
      CCDS29984.1
      UniProtKB/Swiss-Prot
      P70315
      UniProtKB/TrEMBL
      Q53WY0
      Related
      ENSMUSP00000033505.6, OTTMUSP00000019623, ENSMUST00000033505.6, OTTMUST00000043683
      Conserved Domains (2) summary
      pfam00568
      Location:38147
      WH1; WH1 domain
      pfam00786
      Location:239295
      PBD; P21-Rho-binding domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000086.7 Reference GRCm38.p4 C57BL/6J

      Range
      8081466..8090491 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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