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    Myh9 myosin, heavy polypeptide 9, non-muscle [ Mus musculus (house mouse) ]

    Gene ID: 17886, updated on 9-May-2017
    Official Symbol
    Myh9provided by MGI
    Official Full Name
    myosin, heavy polypeptide 9, non-muscleprovided by MGI
    Primary source
    MGI:MGI:107717
    See related
    Ensembl:ENSMUSG00000022443 Vega:OTTMUSG00000016428
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fltn; Myhn1; Myhn-1; TU72.6; NMHCIIA; NMMHC-A; NMMHC-IIA
    Orthologs
    Location:
    15 E1; 15 36.81 cM
    Exon count:
    41
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 15 NC_000081.6 (77760585..77842175, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (77591019..77672545, complement)

    Chromosome 15 - NC_000081.6Genomic Context describing neighboring genes Neighboring gene apolipoprotein L 9b Neighboring gene apolipoprotein L 8 Neighboring gene thioredoxin 2 Neighboring gene FAD-dependent oxidoreductase domain containing 2

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • E030044M24Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ADP binding ISO
    Inferred from Sequence Orthology
    more info
     
    ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    ATPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    actin binding ISO
    Inferred from Sequence Orthology
    more info
     
    actin filament binding ISO
    Inferred from Sequence Orthology
    more info
     
    actin-dependent ATPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    cadherin binding ISO
    Inferred from Sequence Orthology
    more info
     
    calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    microfilament motor activity ISO
    Inferred from Sequence Orthology
    more info
     
    motor activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein anchor ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    actin cytoskeleton reorganization ISO
    Inferred from Sequence Orthology
    more info
     
    NOT actin filament capping IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT actin filament polymerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    actin filament-based movement ISO
    Inferred from Sequence Orthology
    more info
     
    actomyosin structure organization ISO
    Inferred from Sequence Orthology
    more info
     
    angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    blood vessel endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell morphogenesis involved in differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cytokinetic process ISO
    Inferred from Sequence Orthology
    more info
     
    establishment of T cell polarity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    establishment of meiotic spindle localization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    meiotic spindle organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane protein ectodomain proteolysis ISO
    Inferred from Sequence Orthology
    more info
     
    movement of cell or subcellular component IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    myoblast fusion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of actin filament severing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of actin filament severing ISO
    Inferred from Sequence Orthology
    more info
     
    phagocytosis, engulfment IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    platelet aggregation ISO
    Inferred from Sequence Orthology
    more info
     
    platelet formation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein processing in phagocytic vesicle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein transport ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cell shape IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of cell shape ISO
    Inferred from Sequence Orthology
    more info
     
    single organismal cell-cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    uropod organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    colocalizes_with COP9 signalosome ISO
    Inferred from Sequence Orthology
    more info
     
    actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    actomyosin ISO
    Inferred from Sequence Orthology
    more info
     
    actomyosin contractile ring ISO
    Inferred from Sequence Orthology
    more info
     
    brush border IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell cortex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell leading edge ISO
    Inferred from Sequence Orthology
    more info
     
    cell-cell adherens junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cleavage furrow ISO
    Inferred from Sequence Orthology
    more info
     
    cortical cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular matrix ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with focal adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with immunological synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with immunological synapse ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with integrin complex ISO
    Inferred from Sequence Orthology
    more info
     
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    myosin II complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    myosin II complex ISO
    Inferred from Sequence Orthology
    more info
     
    myosin II filament ISO
    Inferred from Sequence Orthology
    more info
     
    myosin complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with neuromuscular junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    protein complex ISO
    Inferred from Sequence Orthology
    more info
     
    ruffle ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with spindle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    stress fiber IDA
    Inferred from Direct Assay
    more info
    PubMed 
    stress fiber ISO
    Inferred from Sequence Orthology
    more info
     
    uropod IDA
    Inferred from Direct Assay
    more info
    PubMed 
    uropod ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    myosin-9
    Names
    NMHC II-A
    NMMHC II-a
    cellular myosin heavy chain, type A
    flectin
    myosin IIA
    myosin heavy chain IX
    non-muscle myosin heavy chain IIa

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022410.3NP_071855.2  myosin-9

      See identical proteins and their annotated locations for NP_071855.2

      Status: VALIDATED

      Source sequence(s)
      AK147211, CJ130312, CJ240806
      Consensus CDS
      CCDS27605.1
      UniProtKB/Swiss-Prot
      Q8VDD5
      Related
      ENSMUSP00000016771.6, OTTMUSP00000017674, ENSMUST00000016771.12, OTTMUST00000039563
      Conserved Domains (8) summary
      cl22853
      Location:95764
      Motor_domain; Myosin and Kinesin motor domain
      pfam00063
      Location:83764
      Myosin_head; Myosin head (motor domain)
      pfam01576
      Location:8421921
      Myosin_tail_1; Myosin tail
      pfam02736
      Location:3068
      Myosin_N; Myosin N-terminal SH3-like domain
      cl00240
      Location:12061261
      RRF; Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another round of ...
      cl02376
      Location:16101678
      DUF2390; Protein of unknown function (DUF2390)
      cl15254
      Location:10381149
      UBAN; polyubiquitin binding domain of NEMO and related proteins
      cl23720
      Location:14801587
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000081.6 Reference GRCm38.p4 C57BL/6J

      Range
      77760585..77842175 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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