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    Nr1i3 nuclear receptor subfamily 1, group I, member 3 [ Mus musculus (house mouse) ]

    Gene ID: 12355, updated on 4-Jun-2017
    Official Symbol
    Nr1i3provided by MGI
    Official Full Name
    nuclear receptor subfamily 1, group I, member 3provided by MGI
    Primary source
    MGI:MGI:1346307
    See related
    Ensembl:ENSMUSG00000005677 Vega:OTTMUSG00000022426
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CAR; MB67; Care2; ESTM32; AA209988; AI551208; CAR-beta
    Orthologs
    Location:
    1 H3; 1 79.21 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (171213932..171218845)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (173144101..173148975)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene myelin protein zero Neighboring gene Purkinje cell protein 4-like 1 Neighboring gene translocase of outer mitochondrial membrane 40 homolog-like (yeast) Neighboring gene apolipoprotein A-II Neighboring gene Fc receptor, IgE, high affinity I, gamma polypeptide

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC107281

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA polymerase II regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    steroid hormone receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    thyroid hormone receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    transcription factor activity, sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    negative regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    steroid hormone mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    nuclear receptor subfamily 1 group I member 3
    Names
    constitutive androstane receptor
    constitutively transactivates RAREs
    orphan nuclear receptor MB67

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001243062.1NP_001229991.1  nuclear receptor subfamily 1 group I member 3 isoform 2

      See identical proteins and their annotated locations for NP_001229991.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the 3' coding region which results in a frameshift, compared to variant 1. This results in a shorter and distinct C-terminus in isoform 2, compared to isoform 1.
      Source sequence(s)
      AI132241, AK133515
      Consensus CDS
      CCDS56654.1
      UniProtKB/Swiss-Prot
      O35627
      Related
      ENSMUSP00000074915.5, OTTMUSP00000025552, ENSMUST00000075469.11, OTTMUST00000053711
      Conserved Domains (2) summary
      cd07156
      Location:2192
      NR_DBD_VDR_like; The DNA-binding domain of vitamin D receptors (VDR) like nuclear receptor family is composed of two C4-type zinc fingers
      cl11397
      Location:116281
      NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
    2. NM_001243063.1NP_001229992.1  nuclear receptor subfamily 1 group I member 3 isoform 3

      See identical proteins and their annotated locations for NP_001229992.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an in-frame alternate splice site in the 3' coding, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
      Source sequence(s)
      AI132241, AK133515, BC089541
      Consensus CDS
      CCDS56655.1
      UniProtKB/Swiss-Prot
      O35627
      UniProtKB/TrEMBL
      Q5FW96
      Related
      ENSMUSP00000106960.1, OTTMUSP00000025553, ENSMUST00000111328.7, OTTMUST00000053716
      Conserved Domains (2) summary
      cd07156
      Location:2192
      NR_DBD_VDR_like; The DNA-binding domain of vitamin D receptors (VDR) like nuclear receptor family is composed of two C4-type zinc fingers
      cl11397
      Location:116355
      NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
    3. NM_009803.5NP_033933.2  nuclear receptor subfamily 1 group I member 3 isoform 1

      See identical proteins and their annotated locations for NP_033933.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC163497, AI132241, AK133515
      Consensus CDS
      CCDS15480.1
      UniProtKB/Swiss-Prot
      O35627
      Related
      ENSMUSP00000005820.4, OTTMUSP00000025500, ENSMUST00000005820.10, OTTMUST00000053615
      Conserved Domains (2) summary
      cd07156
      Location:2192
      NR_DBD_VDR_like; The DNA-binding domain of vitamin D receptors (VDR) like nuclear receptor family is composed of two C4-type zinc fingers
      cl11397
      Location:116356
      NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

      Range
      171213932..171218845
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006496632.2XP_006496695.1  nuclear receptor subfamily 1 group I member 3 isoform X6

      Conserved Domains (1) summary
      cl11397
      Location:56190
      NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
    2. XM_006496631.3XP_006496694.1  nuclear receptor subfamily 1 group I member 3 isoform X5

      Conserved Domains (1) summary
      cl11397
      Location:56191
      NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
    3. XM_006496628.2XP_006496691.1  nuclear receptor subfamily 1 group I member 3 isoform X1

      Conserved Domains (2) summary
      cd07156
      Location:2192
      NR_DBD_VDR_like; The DNA-binding domain of vitamin D receptors (VDR) like nuclear receptor family is composed of two C4-type zinc fingers
      cl11397
      Location:116318
      NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
    4. XM_011238743.2XP_011237045.1  nuclear receptor subfamily 1 group I member 3 isoform X2

      Conserved Domains (2) summary
      cd07156
      Location:2192
      NR_DBD_VDR_like; The DNA-binding domain of vitamin D receptors (VDR) like nuclear receptor family is composed of two C4-type zinc fingers
      cl11397
      Location:116281
      NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
    5. XM_006496629.2XP_006496692.1  nuclear receptor subfamily 1 group I member 3 isoform X3

      See identical proteins and their annotated locations for XP_006496692.1

      UniProtKB/TrEMBL
      Q3UEP1
      Conserved Domains (1) summary
      cl11397
      Location:1219
      NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
    6. XM_006496630.3XP_006496693.1  nuclear receptor subfamily 1 group I member 3 isoform X3

      See identical proteins and their annotated locations for XP_006496693.1

      UniProtKB/TrEMBL
      Q3UEP1
      Related
      ENSMUSP00000137683.1, OTTMUSP00000063017, ENSMUST00000155126.7, OTTMUST00000053712
      Conserved Domains (1) summary
      cl11397
      Location:1219
      NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
    7. XM_011238744.2XP_011237046.1  nuclear receptor subfamily 1 group I member 3 isoform X4

      Conserved Domains (2) summary
      cd07156
      Location:2192
      NR_DBD_VDR_like; The DNA-binding domain of vitamin D receptors (VDR) like nuclear receptor family is composed of two C4-type zinc fingers
      cl11397
      Location:116193
      NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators

    RNA

    1. XR_373595.3 RNA Sequence

    2. XR_373594.3 RNA Sequence

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