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    Mpp4 membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4) [ Mus musculus (house mouse) ]

    Gene ID: 227157, updated on 26-Nov-2016
    Official Symbol
    Mpp4provided by MGI
    Official Full Name
    membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4)provided by MGI
    Primary source
    MGI:MGI:2386681
    See related
    Ensembl:ENSMUSG00000079550 Vega:OTTMUSG00000047223
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dlg6
    Orthologs
    Location:
    1; 1 C1.3
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (59120935..59163389, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (59177779..59220233, complement)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 11 (human) Neighboring gene transmembrane protein 237 Neighboring gene predicted gene, 19125 Neighboring gene amyotrophic lateral sclerosis 2 (juvenile) Neighboring gene predicted gene, 33667 Neighboring gene cyclin-dependent kinase 15

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    protein localization to synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    presynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    MAGUK p55 subfamily member 4
    Names
    discs large homolog 6
    mDLG6
    membrane palmitoylated protein 4

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164682.1NP_001158154.1  MAGUK p55 subfamily member 4 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK044682, BC061694, BM945398, DV648961
      Consensus CDS
      CCDS48272.1
      UniProtKB/Swiss-Prot
      Q6P7F1
      UniProtKB/TrEMBL
      D3Z0G8
      Related
      ENSMUSP00000109914, OTTMUSP00000067080, ENSMUST00000114275, OTTMUST00000122110
      Conserved Domains (6) summary
      smart00569
      Location:66100
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd12034
      Location:264324
      SH3_MPP4; Src Homology 3 domain of Membrane Protein, Palmitoylated 4 (or MAGUK p55 subfamily member 4)
      smart00072
      Location:454637
      GuKc; Guanylate kinase homologues
      cd00992
      Location:171250
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:446636
      Guanylate_kin; Guanylate kinase
      pfam02828
      Location:108154
      L27; L27 domain
    2. NM_145143.3NP_660125.2  MAGUK p55 subfamily member 4 isoform 2

      See identical proteins and their annotated locations for NP_660125.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      BC061694, BI737565
      Consensus CDS
      CCDS48271.1
      UniProtKB/Swiss-Prot
      Q6P7F1
      Related
      ENSMUSP00000077914, OTTMUSP00000067079, ENSMUST00000078874, OTTMUST00000122109
      Conserved Domains (6) summary
      smart00569
      Location:4781
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd12034
      Location:245305
      SH3_MPP4; Src Homology 3 domain of Membrane Protein, Palmitoylated 4 (or MAGUK p55 subfamily member 4)
      smart00072
      Location:435618
      GuKc; Guanylate kinase homologues
      cd00992
      Location:152231
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:427617
      Guanylate_kin; Guanylate kinase
      pfam02828
      Location:89135
      L27; L27 domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

      Range
      59120935..59163389 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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