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    Cyr61 cysteine rich protein 61 [ Mus musculus (house mouse) ]

    Gene ID: 16007, updated on 15-Apr-2018
    Official Symbol
    Cyr61provided by MGI
    Official Full Name
    cysteine rich protein 61provided by MGI
    Primary source
    MGI:MGI:88613
    See related
    Ensembl:ENSMUSG00000028195 Vega:OTTMUSG00000055191
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CCN1; Igfbp10; AI325051
    Expression
    Broad expression in lung adult (RPKM 41.5), limb E14.5 (RPKM 37.8) and 26 other tissues See more
    Orthologs
    Location:
    3 H2; 3 70.18 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 3 NC_000069.6 (145646971..145649985, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (145309935..145312949, complement)

    Chromosome 3 - NC_000069.6Genomic Context describing neighboring genes Neighboring gene zinc finger, HIT type 6 Neighboring gene predicted gene, 40164 Neighboring gene dimethylarginine dimethylaminohydrolase 1 Neighboring gene ribosomal protein L36A, pseudogene 2 Neighboring gene predicted gene, 35187 Neighboring gene B cell leukemia/lymphoma 10

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    extracellular matrix binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    growth factor binding IEA
    Inferred from Electronic Annotation
    more info
     
    heparin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    insulin-like growth factor binding IEA
    Inferred from Electronic Annotation
    more info
     
    integrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    integrin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    apoptotic process involved in heart morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    atrial septum morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    atrioventricular valve morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cell adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    cell-cell adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    chondroblast differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chorio-allantoic fusion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    extracellular matrix organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intussusceptive angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    labyrinthine layer blood vessel development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cell death IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    osteoblast differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of BMP signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of cartilage development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell-substrate adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of ceramide biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of osteoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of osteoblast proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of phospholipase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    reactive oxygen species metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cell growth IEA
    Inferred from Electronic Annotation
    more info
     
    signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    ventricular septum development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    wound healing, spreading of cells ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    extracellular matrix HDA PubMed 
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular space HDA PubMed 
    Preferred Names
    protein CYR61
    Names
    3CH61
    CCN family member 1
    IBP-10
    IGF-binding protein 10
    IGFBP-10
    cysteine-rich angiogenic inducer 61
    insulin-like growth factor-binding protein 10
    intermediate early

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010516.2NP_034646.1  protein CYR61 precursor

      See identical proteins and their annotated locations for NP_034646.1

      Status: VALIDATED

      Source sequence(s)
      AC136729, AK159452
      Consensus CDS
      CCDS17895.1
      UniProtKB/Swiss-Prot
      P18406
      UniProtKB/TrEMBL
      Q3TX21
      Related
      ENSMUSP00000029846.3, OTTMUSP00000072117, ENSMUST00000029846.4, OTTMUST00000136695
      Conserved Domains (4) summary
      pfam00007
      Location:291373
      Cys_knot; Cystine-knot domain
      smart00209
      Location:230270
      TSP1; Thrombospondin type 1 repeats
      smart00214
      Location:100159
      VWC; von Willebrand factor (vWF) type C domain
      pfam00219
      Location:2678
      IGFBP; Insulin-like growth factor binding protein

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000069.6 Reference GRCm38.p4 C57BL/6J

      Range
      145646971..145649985 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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