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    Notch1 notch 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25496, updated on 25-May-2017
    Official Symbol
    Notch1provided by RGD
    Official Full Name
    notch 1provided by RGD
    Primary source
    RGD:3187
    See related
    Ensembl:ENSRNOG00000019322
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    TAN1; NOTCH
    Summary
    transmembrane receptor; involved in cell-cell interactions important for development and pattern formation [RGD, Feb 2006]
    Orthologs
    Location:
    3p13
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (3905562..3951015, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 3 NC_005102.3 (9266663..9311575, complement)

    Chromosome 3 - NC_005102.4Genomic Context describing neighboring genes Neighboring gene inositol polyphosphate-5-phosphatase E Neighboring gene SEC16 homolog A, endoplasmic reticulum export factor Neighboring gene uncharacterized LOC103691754 Neighboring gene uncharacterized LOC108350341

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    Notch binding IEA
    Inferred from Electronic Annotation
    more info
     
    Notch binding ISO
    Inferred from Sequence Orthology
    more info
     
    calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    chromatin DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    chromatin DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    core promoter binding ISO
    Inferred from Sequence Orthology
    more info
     
    core promoter binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enzyme binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enzyme inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enzyme inhibitor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor activity, sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    transcription factor activity, sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcriptional activator activity, RNA polymerase II transcription factor binding IEA
    Inferred from Electronic Annotation
    more info
     
    transcriptional activator activity, RNA polymerase II transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    Notch signaling involved in heart development ISO
    Inferred from Sequence Orthology
    more info
     
    Notch signaling involved in heart development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Notch signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Notch signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    Notch signaling pathway TAS
    Traceable Author Statement
    more info
     
    Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    animal organ regeneration IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    aortic valve morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    aortic valve morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    apoptotic process involved in embryonic digit morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    apoptotic process involved in embryonic digit morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    arterial endothelial cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    arterial endothelial cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    astrocyte differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    atrioventricular node development IEA
    Inferred from Electronic Annotation
    more info
     
    atrioventricular node development ISO
    Inferred from Sequence Orthology
    more info
     
    atrioventricular valve morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    auditory receptor cell fate commitment IEA
    Inferred from Electronic Annotation
    more info
     
    auditory receptor cell fate commitment ISO
    Inferred from Sequence Orthology
    more info
     
    axonogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    axonogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    brain development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    branching morphogenesis of an epithelial tube IEA
    Inferred from Electronic Annotation
    more info
     
    branching morphogenesis of an epithelial tube ISO
    Inferred from Sequence Orthology
    more info
     
    cardiac atrium morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    cardiac chamber formation ISO
    Inferred from Sequence Orthology
    more info
     
    cardiac epithelial to mesenchymal transition ISO
    Inferred from Sequence Orthology
    more info
     
    cardiac left ventricle morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    cardiac left ventricle morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    cardiac muscle cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    cardiac muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    cardiac muscle tissue morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    cardiac right atrium morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    cardiac right atrium morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    cardiac right ventricle formation IEA
    Inferred from Electronic Annotation
    more info
     
    cardiac right ventricle formation ISO
    Inferred from Sequence Orthology
    more info
     
    cardiac septum morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    cardiac vascular smooth muscle cell development IEA
    Inferred from Electronic Annotation
    more info
     
    cardiac vascular smooth muscle cell development ISO
    Inferred from Sequence Orthology
    more info
     
    cardiac ventricle morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    cell differentiation in spinal cord IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cell fate commitment ISO
    Inferred from Sequence Orthology
    more info
     
    cell fate specification IEA
    Inferred from Electronic Annotation
    more info
     
    cell fate specification ISO
    Inferred from Sequence Orthology
    more info
     
    cell migration involved in endocardial cushion formation IEA
    Inferred from Electronic Annotation
    more info
     
    cell migration involved in endocardial cushion formation ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to follicle-stimulating hormone stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to follicle-stimulating hormone stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to vascular endothelial growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to vascular endothelial growth factor stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cilium assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    collecting duct development IEA
    Inferred from Electronic Annotation
    more info
     
    collecting duct development ISO
    Inferred from Sequence Orthology
    more info
     
    compartment pattern specification IEA
    Inferred from Electronic Annotation
    more info
     
    compartment pattern specification ISO
    Inferred from Sequence Orthology
    more info
     
    coronary artery morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    coronary artery morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    coronary vein morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    coronary vein morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    determination of left/right symmetry ISO
    Inferred from Sequence Orthology
    more info
     
    distal tubule development IEA
    Inferred from Electronic Annotation
    more info
     
    distal tubule development ISO
    Inferred from Sequence Orthology
    more info
     
    embryonic hindlimb morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    embryonic hindlimb morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    embryonic limb morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    endocardial cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    endocardial cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    endocardial cushion development ISO
    Inferred from Sequence Orthology
    more info
     
    endocardial cushion morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    endocardium development ISO
    Inferred from Sequence Orthology
    more info
     
    endocardium morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    endocardium morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    endoderm development IEA
    Inferred from Electronic Annotation
    more info
     
    endoderm development ISO
    Inferred from Sequence Orthology
    more info
     
    epidermis development ISO
    Inferred from Sequence Orthology
    more info
     
    epithelial to mesenchymal transition ISO
    Inferred from Sequence Orthology
    more info
     
    epithelial to mesenchymal transition involved in endocardial cushion formation IEA
    Inferred from Electronic Annotation
    more info
     
    epithelial to mesenchymal transition involved in endocardial cushion formation ISO
    Inferred from Sequence Orthology
    more info
     
    forebrain development IEA
    Inferred from Electronic Annotation
    more info
     
    forebrain development ISO
    Inferred from Sequence Orthology
    more info
     
    foregut morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    foregut morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    glial cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    glomerular mesangial cell development IEA
    Inferred from Electronic Annotation
    more info
     
    glomerular mesangial cell development ISO
    Inferred from Sequence Orthology
    more info
     
    growth involved in heart morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    growth involved in heart morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    hair follicle morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    hair follicle morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    heart development ISO
    Inferred from Sequence Orthology
    more info
     
    heart looping IEA
    Inferred from Electronic Annotation
    more info
     
    heart looping ISO
    Inferred from Sequence Orthology
    more info
     
    heart trabecula morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    humoral immune response IEA
    Inferred from Electronic Annotation
    more info
     
    humoral immune response ISO
    Inferred from Sequence Orthology
    more info
     
    in utero embryonic development IEA
    Inferred from Electronic Annotation
    more info
     
    in utero embryonic development ISO
    Inferred from Sequence Orthology
    more info
     
    inflammatory response to antigenic stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    inflammatory response to antigenic stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    interleukin-4 secretion IEA
    Inferred from Electronic Annotation
    more info
     
    interleukin-4 secretion ISO
    Inferred from Sequence Orthology
    more info
     
    keratinocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    keratinocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    left/right axis specification IEA
    Inferred from Electronic Annotation
    more info
     
    left/right axis specification ISO
    Inferred from Sequence Orthology
    more info
     
    liver development IEA
    Inferred from Electronic Annotation
    more info
     
    liver development ISO
    Inferred from Sequence Orthology
    more info
     
    lung development IEA
    Inferred from Electronic Annotation
    more info
     
    lung development ISO
    Inferred from Sequence Orthology
    more info
     
    mesenchymal cell development IEA
    Inferred from Electronic Annotation
    more info
     
    mesenchymal cell development ISO
    Inferred from Sequence Orthology
    more info
     
    mitral valve formation IEA
    Inferred from Electronic Annotation
    more info
     
    mitral valve formation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of BMP signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of BMP signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of anoikis IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of anoikis ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of auditory receptor cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of auditory receptor cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of calcium ion-dependent exocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of calcium ion-dependent exocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of canonical Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of catalytic activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of catalytic activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of cell death ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell migration involved in sprouting angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell migration involved in sprouting angiogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of cell-substrate adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cell-substrate adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of endothelial cell chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of endothelial cell chemotaxis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of glial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of glial cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of myoblast differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of myoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of myotube differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of myotube differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of neurogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of neurogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of oligodendrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of oligodendrocyte differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of ossification ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of osteoblast differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of osteoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of photoreceptor cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of photoreceptor cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of pro-B cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of pro-B cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of stem cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of stem cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription from RNA polymerase II promoter ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    neural tube development IEA
    Inferred from Electronic Annotation
    more info
     
    neural tube development ISO
    Inferred from Sequence Orthology
    more info
     
    neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    neuron fate commitment ISO
    Inferred from Sequence Orthology
    more info
     
    neuronal stem cell population maintenance IEA
    Inferred from Electronic Annotation
    more info
     
    neuronal stem cell population maintenance ISO
    Inferred from Sequence Orthology
    more info
     
    oligodendrocyte differentiation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    pericardium morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    pericardium morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of BMP signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of BMP signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of JAK-STAT cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of JAK-STAT cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of Notch signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of Notch signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of aorta morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of aorta morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of astrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of astrocyte differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of cardiac muscle cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cardiac muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of endothelial cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of epithelial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of epithelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of epithelial to mesenchymal transition IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of epithelial to mesenchymal transition ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of glial cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of keratinocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of keratinocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of neuroblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription from RNA polymerase II promoter in response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription from RNA polymerase II promoter in response to hypoxia ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of transcription of Notch receptor target IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription of Notch receptor target ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription, DNA-templated ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of viral genome replication IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of viral genome replication ISO
    Inferred from Sequence Orthology
    more info
     
    prostate gland epithelium morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    prostate gland epithelium morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    pulmonary valve morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    pulmonary valve morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of Notch signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of auditory receptor cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cardioblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of epithelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of epithelial cell proliferation involved in prostate gland development IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of epithelial cell proliferation involved in prostate gland development ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of extracellular matrix assembly IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of extracellular matrix assembly ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of neurogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of somitogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of somitogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    response to corticosteroid IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to lipopolysaccharide IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to muramyl dipeptide IEA
    Inferred from Electronic Annotation
    more info
     
    response to muramyl dipeptide ISO
    Inferred from Sequence Orthology
    more info
     
    secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development IEA
    Inferred from Electronic Annotation
    more info
     
    secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development ISO
    Inferred from Sequence Orthology
    more info
     
    skeletal muscle cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    skeletal muscle cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    somatic stem cell division IEA
    Inferred from Electronic Annotation
    more info
     
    somatic stem cell division ISO
    Inferred from Sequence Orthology
    more info
     
    spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    sprouting angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    sprouting angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    tissue regeneration IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    transcription from RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
     
    tube formation ISO
    Inferred from Sequence Orthology
    more info
     
    tube formation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    vasculogenesis involved in coronary vascular morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    vasculogenesis involved in coronary vascular morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    venous blood vessel morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    venous endothelial cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    venous endothelial cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    ventricular septum morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    ventricular septum morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    ventricular trabecula myocardium morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    ventricular trabecula myocardium morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    MAML1-RBP-Jkappa- ICN1 complex IEA
    Inferred from Electronic Annotation
    more info
     
    MAML1-RBP-Jkappa- ICN1 complex ISO
    Inferred from Sequence Orthology
    more info
     
    acrosomal vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    adherens junction ISO
    Inferred from Sequence Orthology
    more info
     
    adherens junction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    apical plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cell periphery ISO
    Inferred from Sequence Orthology
    more info
     
    cell surface IEA
    Inferred from Electronic Annotation
    more info
     
    cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    cytoskeleton ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    lamellipodium ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    receptor complex IEA
    Inferred from Electronic Annotation
    more info
     
    receptor complex ISO
    Inferred from Sequence Orthology
    more info
     
    ruffle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Preferred Names
    neurogenic locus notch homolog protein 1
    Names
    Drosophila Notch homolog 1 (controlling the the ectodermal and neural cell fate in Drosophila)
    Notch gene homolog 1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105721.1NP_001099191.1  neurogenic locus notch homolog protein 1 precursor

      See identical proteins and their annotated locations for NP_001099191.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474001
      UniProtKB/Swiss-Prot
      Q07008
      Related
      ENSRNOP00000026212.6, ENSRNOT00000026212.7
      Conserved Domains (11) summary
      smart00004
      Location:14421479
      NL; Domain found in Notch and Lin-12
      cd00054
      Location:869905
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00204
      Location:19122024
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam00066
      Location:14871522
      Notch; LNR domain
      pfam03153
      Location:22012417
      TFIIA; Transcription factor IIA, alpha/beta subunit
      pfam06816
      Location:15671618
      NOD; NOTCH protein
      pfam07684
      Location:16621719
      NODP; NOTCH protein
      pfam11235
      Location:23392490
      Med25_SD1; Mediator complex subunit 25 synapsin 1
      pfam11936
      Location:24542516
      DUF3454; Domain of unknown function (DUF3454)
      pfam12796
      Location:19222015
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:18701915
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005102.4 Reference Rnor_6.0 Primary Assembly

      Range
      3905562..3951015 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000071.1 Alternate Rn_Celera

      Range
      4097915..4143369 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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