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    MIF macrophage migration inhibitory factor [ Homo sapiens (human) ]

    Gene ID: 4282, updated on 10-Dec-2017
    Official Symbol
    MIFprovided by HGNC
    Official Full Name
    macrophage migration inhibitory factorprovided by HGNC
    Primary source
    HGNC:HGNC:7097
    See related
    Ensembl:ENSG00000240972 MIM:153620; Vega:OTTHUMG00000150773
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GIF; GLIF; MMIF
    Summary
    This gene encodes a lymphokine involved in cell-mediated immunity, immunoregulation, and inflammation. It plays a role in the regulation of macrophage function in host defense through the suppression of anti-inflammatory effects of glucocorticoids. This lymphokine and the JAB1 protein form a complex in the cytosol near the peripheral plasma membrane, which may indicate an additional role in integrin signaling pathways. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in kidney (RPKM 164.4), prostate (RPKM 93.1) and 21 other tissues See more
    Orthologs
    Location:
    22q11.23
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 22 NC_000022.11 (23894378..23895222)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (24236565..24237409)

    Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 Neighboring gene derlin 3 Neighboring gene solute carrier family 2 member 11 Neighboring gene RNA, 7SL, cytoplasmic 268, pseudogene Neighboring gene MIF antisense RNA 1 Neighboring gene uncharacterized LOC107985558 Neighboring gene kelch like family member 5 pseudogene

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Associated conditions

    Description Tests
    Rheumatoid arthritis, systemic juvenile
    MedGen: C1858558 OMIM: 604302 GeneReviews: Not available
    Compare labs

    NHGRI GWAS Catalog

    Description
    Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    Nef nef HIV-1 Nef specifically incorporates CSF2, PPBP (NAP2), CCL5, TNF, FAS, CXCL1, IL12B, MIF and OSM into plasma extracellular vesicles from HIV-1 infected patient samples PubMed
    Tat tat HIV-1 Tat upregulates the expression of macrophage migration inhibitory factor gene (glycosylation-inhibiting factor, MIF) in mammary epithelial cells PubMed
    Vpr vpr Treatment of human primary astrocytes with HIV-1 Vpr upregulates secretion of IL-6, IL-8, MCP-1, and MIF and downregulates secretion of serpin E1, a serine proteinase inhibitor (known as PAI-1) PubMed
    Vpu vpu HIV-1 Vpu-expressing U937 monocytes coculture with LX2 stellate cells to upregulate expression of profibrogenic markers COL-1, PCT, SMA-1, VEGF, and MMP2, which is inhibited by MIF treatment PubMed

    Go to the HIV-1, Human Interaction Database

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    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    chemoattractant activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytokine activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytokine receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytokine receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    dopachrome isomerase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    phenylpyruvate tautomerase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protease binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    DNA damage response, signal transduction by p53 class mediator IEA
    Inferred from Electronic Annotation
    more info
     
    carboxylic acid metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell aging IEA
    Inferred from Electronic Annotation
    more info
     
    cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell surface receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    interleukin-12-mediated signaling pathway TAS
    Traceable Author Statement
    more info
     
    leukocyte migration TAS
    Traceable Author Statement
    more info
     
    negative regulation of DNA damage response, signal transduction by p53 class mediator IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of cell aging IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of cell cycle arrest IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of cellular protein metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of macrophage chemotaxis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of mature B cell apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of myeloid cell apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    neutrophil degranulation TAS
    Traceable Author Statement
    more info
     
    positive chemotaxis IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of B cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of ERK1 and ERK2 cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of ERK1 and ERK2 cascade IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of MAP kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of arachidonic acid secretion IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of chemokine (C-X-C motif) ligand 2 production IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cytokine secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of fibroblast proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of lipopolysaccharide-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of myeloid leukocyte cytokine production involved in immune response IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of prostaglandin secretion involved in immune response IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of protein kinase A signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of tumor necrosis factor production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    prostaglandin biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein homotrimerization IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    regulation of macrophage activation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    regulation of receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular region TAS
    Traceable Author Statement
    more info
     
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ficolin-1-rich granule lumen TAS
    Traceable Author Statement
    more info
     
    myelin sheath IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    secretory granule lumen TAS
    Traceable Author Statement
    more info
     
    vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    macrophage migration inhibitory factor
    Names
    L-dopachrome isomerase
    L-dopachrome tautomerase
    macrophage migration inhibitory factor (glycosylation-inhibiting factor)
    phenylpyruvate tautomerase
    NP_002406.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012099.1 RefSeqGene

      Range
      5001..5845
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_002415.1NP_002406.1  macrophage migration inhibitory factor

      See identical proteins and their annotated locations for NP_002406.1

      Status: REVIEWED

      Source sequence(s)
      L19686
      Consensus CDS
      CCDS13819.1
      UniProtKB/Swiss-Prot
      P14174
      UniProtKB/TrEMBL
      I4AY87
      Related
      ENSP00000215754.7, OTTHUMP00000198465, ENST00000215754.7, OTTHUMT00000320009
      Conserved Domains (1) summary
      pfam01187
      Location:2115
      MIF; Macrophage migration inhibitory factor (MIF)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000022.11 Reference GRCh38.p7 Primary Assembly

      Range
      23894378..23895222
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p7 ALT_REF_LOCI_1

    Genomic

    1. NT_187633.1 Reference GRCh38.p7 ALT_REF_LOCI_1

      Range
      130740..131584
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018933.2 Alternate CHM1_1.1

      Range
      24248957..24249801
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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