Format

Send to:

Choose Destination

Links from PubMed

    • Showing Current items.

    SERPINA5 serpin family A member 5 [ Homo sapiens (human) ]

    Gene ID: 5104, updated on 5-Feb-2017
    Official Symbol
    SERPINA5provided by HGNC
    Official Full Name
    serpin family A member 5provided by HGNC
    Primary source
    HGNC:HGNC:8723
    See related
    Ensembl:ENSG00000188488 MIM:601841; Vega:OTTHUMG00000170860
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PCI; PAI3; PAI-3; PCI-B; PROCI; PLANH3
    Summary
    The protein encoded by this gene is a member of the serpin family of proteins, a group of proteins that inhibit serine proteases. This gene is one in a cluster of serpin genes located on the q arm of chromosome 14. This family member is a glycoprotein that can inhibit several serine proteases, including protein C and various plasminogen activators and kallikreins, and it thus plays diverse roles in hemostasis and thrombosis in multiple organs. [provided by RefSeq, Aug 2012]
    Orthologs
    Location:
    14q32.13
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 14 NC_000014.9 (94581369..94593120)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (95047706..95059457)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene serpin family A member 12 Neighboring gene serpin family A member 4 Neighboring gene serpin family A member 3 Neighboring gene adiponectin receptor 1 pseudogene 2

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Common Pathway of Fibrin Clot Formation, organism-specific biosystem (from REACTOME)
      Common Pathway of Fibrin Clot Formation, organism-specific biosystemThe common pathway consists of the cascade of activation events leading from the formation of activated factor X to the formation of active thrombin, the cleavage of fibrinogen by thrombin, and the f...
    • Complement and Coagulation Cascades, organism-specific biosystem (from WikiPathways)
      Complement and Coagulation Cascades, organism-specific biosystemBlood coagulation is a series of coordinated and calcium-dependent proenzyme-to-serine protease conversions likely to be localized on the surfaces of activated cells in vivo. It culminates in the for...
    • Complement and coagulation cascades, organism-specific biosystem (from KEGG)
      Complement and coagulation cascades, organism-specific biosystemThe complement system is a proteolytic cascade in blood plasma and a mediator of innate immunity, a nonspecific defense mechanism against pathogens. There are three pathways of complement activation:...
    • Complement and coagulation cascades, conserved biosystem (from KEGG)
      Complement and coagulation cascades, conserved biosystemThe complement system is a proteolytic cascade in blood plasma and a mediator of innate immunity, a nonspecific defense mechanism against pathogens. There are three pathways of complement activation:...
    • Formation of Fibrin Clot (Clotting Cascade), organism-specific biosystem (from REACTOME)
      Formation of Fibrin Clot (Clotting Cascade), organism-specific biosystemThe formation of a fibrin clot at the site of an injury to the wall of a normal blood vessel is an essential part of the process to stop blood loss after vascular injury. The reactions that lead to ...
    • Hemostasis, organism-specific biosystem (from REACTOME)
      Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
    • Intrinsic Pathway of Fibrin Clot Formation, organism-specific biosystem (from REACTOME)
      Intrinsic Pathway of Fibrin Clot Formation, organism-specific biosystemThe intrinsic pathway of blood clotting connects interactions among kininogen (high molecular weight kininogen, HK), prekallikrein (PK), and factor XII to the activation of clotting factor X by a ser...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    acrosin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    glycosaminoglycan binding TAS
    Traceable Author Statement
    more info
    PubMed 
    heparin binding TAS
    Traceable Author Statement
    more info
    PubMed 
    phosphatidylcholine binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protease binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    retinoic acid binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    serine-type endopeptidase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    blood coagulation TAS
    Traceable Author Statement
    more info
     
    fusion of sperm to egg plasma membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    lipid transport IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of hydrolase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    seminal vesicle development IEA
    Inferred from Electronic Annotation
    more info
     
    spermatogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    acrosomal membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular region NAS
    Non-traceable Author Statement
    more info
    PubMed 
    extracellular region TAS
    Traceable Author Statement
    more info
    PubMed 
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    platelet alpha granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    platelet dense tubular network IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein C inhibitor-KLK3 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein C inhibitor-PLAT complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein C inhibitor-PLAU complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein C inhibitor-TMPRSS11E complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein C inhibitor-TMPRSS7 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein C inhibitor-coagulation factor V complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein C inhibitor-coagulation factor XI complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein C inhibitor-coagulation factor Xa complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein C inhibitor-plasma kallikrein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein C inhibitor-thrombin complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    plasma serine protease inhibitor
    Names
    acrosomal serine protease inhibitor
    plasminogen activator inhibitor III
    plasminogen activator inhibitor-3
    protein C inhibitor
    serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
    serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_032908.2 RefSeqGene

      Range
      24928..36679
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000624.5NP_000615.3  plasma serine protease inhibitor preproprotein

      See identical proteins and their annotated locations for NP_000615.3

      Status: REVIEWED

      Source sequence(s)
      AI114432, AK293192, BC008915, DC394575, HY003178
      Consensus CDS
      CCDS9928.1
      UniProtKB/Swiss-Prot
      P05154
      UniProtKB/TrEMBL
      A0A024R6N9, B4DDH1
      Related
      ENSP00000333203, ENST00000329597
      Conserved Domains (1) summary
      cd02056
      Location:44403
      alpha-1-antitrypsin_like; alpha-1-antitrypsin_like. This family contains a variety of different members of clade A of the serpin superfamily. They include the classical serine proteinase inhibitors, alpha-1-antitrypsin and alpha-1-antichymotrypsin, protein C inhibitor, ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p7 Primary Assembly

      Range
      94581369..94593120
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018925.2 Alternate CHM1_1.1

      Range
      94985498..94997214
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center