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    Prok2 prokineticin 2 [ Mus musculus (house mouse) ]

    Gene ID: 50501, updated on 8-Apr-2018
    Official Symbol
    Prok2provided by MGI
    Official Full Name
    prokineticin 2provided by MGI
    Primary source
    MGI:MGI:1354178
    See related
    Ensembl:ENSMUSG00000030069 Vega:OTTMUSG00000057660
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Bv8; PK2; Prok1
    Expression
    Restricted expression toward testis adult (RPKM 10.4) See more
    Orthologs
    Location:
    6 D3; 6 46.29 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 6 NC_000072.6 (99711299..99726392, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (99661293..99676386, complement)

    Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 4E member 3 Neighboring gene G protein-coupled receptor 27 Neighboring gene predicted gene, 26748 Neighboring gene predicted gene 5314

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    G-protein coupled receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    G-protein coupled receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    G-protein coupled receptor binding TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    activation of MAPK activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    circadian rhythm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    circadian rhythm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    coronary vasculature development TAS
    Traceable Author Statement
    more info
    PubMed 
    epicardium-derived cardiac endothelial cell differentiation TAS
    Traceable Author Statement
    more info
    PubMed 
    epicardium-derived cardiac vascular smooth muscle cell differentiation TAS
    Traceable Author Statement
    more info
    PubMed 
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    neuropeptide signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    positive regulation of smooth muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of angiogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    rhythmic process IEA
    Inferred from Electronic Annotation
    more info
     
    spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    vasculogenesis involved in coronary vascular morphogenesis TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    extracellular region IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Preferred Names
    prokineticin-2
    Names
    Bombina variegata 8 kD protein
    Bombina variegata 8kDa protein
    Bv 8 homolog (Bombina variegata)
    prokineticin 1
    protein Bv8 homolog

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037539.2NP_001032628.1  prokineticin-2 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001032628.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC122929, AF487280, BY232101
      Consensus CDS
      CCDS20388.1
      UniProtKB/Swiss-Prot
      Q9QXU7
      Related
      ENSMUSP00000098678.4, OTTMUSP00000073997, ENSMUST00000101120.10, OTTMUST00000141688
      Conserved Domains (1) summary
      pfam06607
      Location:23104
      Prokineticin; Prokineticin
    2. NM_001170419.1NP_001163890.1  prokineticin-2 isoform 3 precursor

      See identical proteins and their annotated locations for NP_001163890.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame segment compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC122929, BB614931, BY232101
      Consensus CDS
      CCDS51864.1
      UniProtKB/TrEMBL
      G3X8R6
      Related
      ENSMUSP00000008273.6, OTTMUSP00000073999, ENSMUST00000008273.7, OTTMUST00000141690
      Conserved Domains (1) summary
      pfam06607
      Location:3262
      Prokineticin; Prokineticin
    3. NM_015768.2NP_056583.1  prokineticin-2 isoform 1 precursor

      See identical proteins and their annotated locations for NP_056583.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC122929, AK015462, BY232101
      Consensus CDS
      CCDS20389.1
      UniProtKB/Swiss-Prot
      Q9QXU7
      UniProtKB/TrEMBL
      Q14AB2
      Related
      ENSMUSP00000032152.8, OTTMUSP00000073998, ENSMUST00000032152.13, OTTMUST00000141689
      Conserved Domains (1) summary
      pfam06607
      Location:23125
      Prokineticin; Prokineticin

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000072.6 Reference GRCm38.p4 C57BL/6J

      Range
      99711299..99726392 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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