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    Agtr1a angiotensin II receptor, type 1a [ Mus musculus (house mouse) ]

    Gene ID: 11607, updated on 12-Mar-2017
    Official Symbol
    Agtr1aprovided by MGI
    Official Full Name
    angiotensin II receptor, type 1aprovided by MGI
    Primary source
    MGI:MGI:87964
    See related
    Ensembl:ENSMUSG00000049115 Vega:OTTMUSG00000000668
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AT1; AG2S; AT1a; AT2R1; Agtr1; AT2R1A; Agtr-1a; AI551199; Angtr-1a; 1810074K20Rik
    Location:
    13 A3.2; 13 13.19 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 13 NC_000079.6 (30336356..30382867)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (30428225..30474736)

    Chromosome 13 - NC_000079.6Genomic Context describing neighboring genes Neighboring gene membrane bound O-acyltransferase domain containing 1 Neighboring gene non-POU-domain-containing, octamer binding protein pseudogene Neighboring gene predicted gene, 40863 Neighboring gene ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 Neighboring gene predicted gene, 35109

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC37610

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    D1 dopamine receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    G-protein alpha-subunit binding ISO
    Inferred from Sequence Orthology
    more info
     
    G-protein coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    angiotensin type I receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    angiotensin type I receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    angiotensin type II receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    bradykinin receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    peptide hormone binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein self-association ISO
    Inferred from Sequence Orthology
    more info
     
    signal transducer activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    G-protein coupled receptor signaling pathway IC
    Inferred by Curator
    more info
    PubMed 
    G-protein coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    Rho protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    activation of Janus kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    angiotensin-activated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    blood vessel development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    brain renin-angiotensin system IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    calcium-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
     
    cell chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to dexamethasone stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    dopamine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    drinking behavior IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    drinking behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    drinking behavior ISO
    Inferred from Sequence Orthology
    more info
     
    heart development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    inflammatory response IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    kidney development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    kidney development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    kidney development ISO
    Inferred from Sequence Orthology
    more info
     
    NOT negative regulation of neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of smooth muscle cell apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    phospholipase C-activating G-protein coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    phospholipase C-activating angiotensin-activated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of blood pressure IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of blood pressure IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of blood pressure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of blood pressure ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of branching involved in ureteric bud morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cellular protein metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cholesterol esterification ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cytokine secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of phospholipase A2 activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of receptor recycling ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of superoxide anion generation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of pH ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of renal output by angiotensin IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of smooth muscle cell apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of systemic arterial blood pressure by circulatory renin-angiotensin IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of vasoconstriction ISO
    Inferred from Sequence Orthology
    more info
     
    renin secretion into blood stream IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    renin-angiotensin regulation of aldosterone production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    renin-angiotensin regulation of aldosterone production ISO
    Inferred from Sequence Orthology
    more info
     
    response to estrogen ISO
    Inferred from Sequence Orthology
    more info
     
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    vasoconstriction ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    endomembrane system ISO
    Inferred from Sequence Orthology
    more info
     
    endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    organelle outer membrane ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    recycling endosome ISO
    Inferred from Sequence Orthology
    more info
     
    vesicle lumen ISO
    Inferred from Sequence Orthology
    more info
     
    vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    type-1A angiotensin II receptor
    Names
    angiotensin II type-1A receptor
    angiotensin receptor 1
    angiotensin receptor 1a

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177322.3NP_796296.1  type-1A angiotensin II receptor

      See identical proteins and their annotated locations for NP_796296.1

      Status: VALIDATED

      Source sequence(s)
      AL607131, CJ066917
      Consensus CDS
      CCDS26415.1
      UniProtKB/Swiss-Prot
      P29754
      Related
      ENSMUSP00000070958, OTTMUSP00000000614, ENSMUST00000066412, OTTMUST00000001293
      Conserved Domains (2) summary
      pfam00001
      Location:45302
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      pfam05296
      Location:26224
      TAS2R; Taste receptor protein (TAS2R)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000079.6 Reference GRCm38.p4 C57BL/6J

      Range
      30336356..30382867
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006516534.1XP_006516597.1  type-1A angiotensin II receptor isoform X1

      See identical proteins and their annotated locations for XP_006516597.1

      UniProtKB/Swiss-Prot
      P29754
      Conserved Domains (2) summary
      pfam00001
      Location:45302
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      pfam05296
      Location:26224
      TAS2R; Taste receptor protein (TAS2R)
    2. XM_011244264.2XP_011242566.1  type-1A angiotensin II receptor isoform X1

      See identical proteins and their annotated locations for XP_011242566.1

      UniProtKB/Swiss-Prot
      P29754
      Conserved Domains (2) summary
      pfam00001
      Location:45302
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      pfam05296
      Location:26224
      TAS2R; Taste receptor protein (TAS2R)
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