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    Cdkn1a cyclin-dependent kinase inhibitor 1A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 114851, updated on 7-May-2017
    Official Symbol
    Cdkn1aprovided by RGD
    Official Full Name
    cyclin-dependent kinase inhibitor 1Aprovided by RGD
    Primary source
    RGD:69328
    See related
    Ensembl:ENSRNOG00000000521
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Cip1; UV96; Waf1
    Summary
    a Cdk inhibitor; involved in negative regulation of the cell cycle [RGD, Feb 2006]
    Orthologs
    Location:
    20p12
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (6348422..6358864)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 20 NC_005119.3 (8592437..8602879)

    Chromosome 20 - NC_005119.4Genomic Context describing neighboring genes Neighboring gene serine/threonine kinase 38 Neighboring gene serine and arginine rich splicing factor 3 Neighboring gene RAB44, member RAS oncogene family Neighboring gene allatostatin-A receptor-like

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    cyclin binding IEA
    Inferred from Electronic Annotation
    more info
     
    cyclin binding ISO
    Inferred from Sequence Orthology
    more info
     
    cyclin-dependent protein kinase activating kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    cyclin-dependent protein kinase activating kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    cyclin-dependent protein serine/threonine kinase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
     
    cyclin-dependent protein serine/threonine kinase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein complex binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest IEA
    Inferred from Electronic Annotation
    more info
     
    DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest ISO
    Inferred from Sequence Orthology
    more info
     
    DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator IEA
    Inferred from Electronic Annotation
    more info
     
    DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator ISO
    Inferred from Sequence Orthology
    more info
     
    G1/S transition of mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    G1/S transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    G2/M transition of mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    G2/M transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    Ras protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Ras protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    animal organ regeneration IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cell cycle arrest ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to DNA damage stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to UV-B IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to UV-B ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to amino acid starvation IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to amino acid starvation ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to extracellular stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to gamma radiation IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to gamma radiation ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to heat IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to ionizing radiation ISO
    Inferred from Sequence Orthology
    more info
     
    cellular senescence IEA
    Inferred from Electronic Annotation
    more info
     
    cellular senescence ISO
    Inferred from Sequence Orthology
    more info
     
    intestinal epithelial cell maturation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IEA
    Inferred from Electronic Annotation
    more info
     
    intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator ISO
    Inferred from Sequence Orthology
    more info
     
    mitotic cell cycle arrest IEA
    Inferred from Electronic Annotation
    more info
     
    mitotic cell cycle arrest ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of G1/S transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cell growth IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cyclin-dependent protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cyclin-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cyclin-dependent protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of B cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of B cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell death IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cyclin-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of fibroblast proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of fibroblast proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of programmed cell death IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of programmed cell death ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of reactive oxygen species metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of reactive oxygen species metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of DNA biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of DNA biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cyclin-dependent protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of protein import into nucleus, translocation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of protein import into nucleus, translocation ISO
    Inferred from Sequence Orthology
    more info
     
    replicative senescence IEA
    Inferred from Electronic Annotation
    more info
     
    response to UV ISO
    Inferred from Sequence Orthology
    more info
     
    response to X-ray IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to arsenic-containing substance IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to corticosterone IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to drug IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to glucocorticoid IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to hyperoxia IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to organic cyclic compound IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to organic substance IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to organonitrogen compound IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to toxic substance IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    PCNA-p21 complex IEA
    Inferred from Electronic Annotation
    more info
     
    PCNA-p21 complex ISO
    Inferred from Sequence Orthology
    more info
     
    cyclin-dependent protein kinase holoenzyme complex IEA
    Inferred from Electronic Annotation
    more info
     
    cyclin-dependent protein kinase holoenzyme complex ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear body IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    nucleolus IEA
    Inferred from Electronic Annotation
    more info
     
    nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein complex ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    cyclin-dependent kinase inhibitor 1
    Names
    cyclin-dependent kinase inhibitor 1A (P21)
    cyclin-dependent kinase inhibitor 1A (p21, Cip1)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_080782.3NP_542960.1  cyclin-dependent kinase inhibitor 1

      See identical proteins and their annotated locations for NP_542960.1

      Status: PROVISIONAL

      Source sequence(s)
      BC100620
      UniProtKB/TrEMBL
      Q64315
      Related
      ENSRNOP00000000628.2, ENSRNOT00000000628.4
      Conserved Domains (1) summary
      pfam02234
      Location:2062
      CDI; Cyclin-dependent kinase inhibitor

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005119.4 Reference Rnor_6.0 Primary Assembly

      Range
      6348422..6358864
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006256128.3XP_006256190.1  cyclin-dependent kinase inhibitor 1 isoform X1

      See identical proteins and their annotated locations for XP_006256190.1

      UniProtKB/TrEMBL
      Q64315
      Related
      ENSRNOP00000072242.1, ENSRNOT00000091731.1
      Conserved Domains (1) summary
      pfam02234
      Location:2062
      CDI; Cyclin-dependent kinase inhibitor

    Alternate Rn_Celera

    Genomic

    1. AC_000088.1 Alternate Rn_Celera

      Range
      8699290..8709718
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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