Format

Send to:

Choose Destination

Links from PubMed

    • Showing Current items.

    Mep1a meprin 1 alpha [ Mus musculus (house mouse) ]

    Gene ID: 17287, updated on 9-Apr-2017
    Official Symbol
    Mep1aprovided by MGI
    Official Full Name
    meprin 1 alphaprovided by MGI
    Primary source
    MGI:MGI:96963
    See related
    Ensembl:ENSMUSG00000023914 Vega:OTTMUSG00000029860
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mep1; Mep-1; Mep-1a; AI098089; AW107200
    Orthologs
    Location:
    17 B3; 17 19.73 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 17 NC_000083.6 (43474324..43504141, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (43611278..43639722, complement)

    Chromosome 17 - NC_000083.6Genomic Context describing neighboring genes Neighboring gene adhesion G protein-coupled receptor F1 Neighboring gene adhesion G protein-coupled receptor F5 Neighboring gene ankyrin repeat domain 66 Neighboring gene RIKEN cDNA 1700071M16 gene Neighboring gene phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Protein digestion and absorption, organism-specific biosystem (from KEGG)
      Protein digestion and absorption, organism-specific biosystemProtein is a dietary component essential for nutritional homeostasis in humans. Normally, ingested protein undergoes a complex series of degradative processes following the action of gastric, pancrea...
    • Protein digestion and absorption, conserved biosystem (from KEGG)
      Protein digestion and absorption, conserved biosystemProtein is a dietary component essential for nutritional homeostasis in humans. Normally, ingested protein undergoes a complex series of degradative processes following the action of gastric, pancrea...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    meprin A complex ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    meprin A subunit alpha
    Names
    endopeptidase-2
    meprin A alpha-subunit
    meprin alpha
    NP_032611.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008585.2NP_032611.2  meprin A subunit alpha

      See identical proteins and their annotated locations for NP_032611.2

      Status: PROVISIONAL

      Source sequence(s)
      BC015258
      Consensus CDS
      CCDS37623.1
      UniProtKB/Swiss-Prot
      P28825
      UniProtKB/TrEMBL
      A0A0R4J043
      Related
      ENSMUSP00000024707.8, ENSMUST00000024707.8
      Conserved Domains (6) summary
      cd06263
      Location:281443
      MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
      smart00137
      Location:276443
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      pfam00008
      Location:688722
      EGF; EGF-like domain
      pfam01400
      Location:86273
      Astacin; Astacin (Peptidase family M12A)
      cl00064
      Location:46271
      ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...
      cl02446
      Location:443607
      MATH; MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000083.6 Reference GRCm38.p4 C57BL/6J

      Range
      43474324..43504141 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006523751.3XP_006523814.1  meprin A subunit alpha isoform X1

      See identical proteins and their annotated locations for XP_006523814.1

      UniProtKB/Swiss-Prot
      P28825
      UniProtKB/TrEMBL
      A0A0R4J043
      Conserved Domains (6) summary
      cd06263
      Location:281443
      MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
      smart00137
      Location:276443
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      pfam00008
      Location:688722
      EGF; EGF-like domain
      pfam01400
      Location:86273
      Astacin; Astacin (Peptidase family M12A)
      cl00064
      Location:46271
      ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...
      cl02446
      Location:443607
      MATH; MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane ...
    Support Center