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    Aasdh aminoadipate-semialdehyde dehydrogenase [ Mus musculus (house mouse) ]

    Gene ID: 231326, updated on 25-May-2017
    Official Symbol
    Aasdhprovided by MGI
    Official Full Name
    aminoadipate-semialdehyde dehydrogenaseprovided by MGI
    Primary source
    MGI:MGI:2442517
    See related
    Ensembl:ENSMUSG00000055923 Vega:OTTMUSG00000026517
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    U26; Acsf4; A830035E16; A230062G08Rik
    Summary
    The gene product is a cytosolic enzyme involved in the production of alpha-aminoadipic acid from alpha-aminoadipic semialdehyde. It is postulated that this enzyme plays a role in lysine metabolism. There is currently debate regarding this enzyme's putative requirement of pyrroloquinoline quinine as an essential cofactor. A related pseudogene has been identified on chromosome 2. [provided by RefSeq, Jan 2010]
    Orthologs
    Location:
    5; 5 C3.3
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (76873659..76905519, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (77304960..77334539, complement)

    Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A730089K16 gene Neighboring gene RIKEN cDNA C530008M17 gene Neighboring gene predicted gene, 34369 Neighboring gene phosphoribosyl pyrophosphate amidotransferase Neighboring gene predicted gene, 42102 Neighboring gene phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoribosylaminoimidazole, succinocarboxamide synthetase

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    L-aminoadipate-semialdehyde dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
     
    catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    molecular_function ND
    No biological Data available
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    amino acid activation for nonribosomal peptide biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    beta-alanine metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cellular_component ND
    No biological Data available
    more info
     
    Preferred Names
    acyl-CoA synthetase family member 4
    Names
    2-aminoadipic 6-semialdehyde dehydrogenase
    protein LYS2 homolog
    putative aminoadipate-semialdehyde dehydrogenase
    NP_776126.1
    XP_006534916.1
    XP_006534917.1
    XP_006534919.1
    XP_006534920.1
    XP_006534922.1
    XP_006534923.1
    XP_011247723.1
    XP_011247724.1
    XP_011247725.1
    XP_017176330.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173765.3NP_776126.1  acyl-CoA synthetase family member 4

      See identical proteins and their annotated locations for NP_776126.1

      Status: REVIEWED

      Source sequence(s)
      AC114666, AC166328, BB077169, BY741513
      Consensus CDS
      CCDS19366.1
      UniProtKB/Swiss-Prot
      Q80WC9
      Related
      ENSMUSP00000113792.1, OTTMUSP00000032707, ENSMUST00000120963.7, OTTMUST00000065592
      Conserved Domains (5) summary
      TIGR01733
      Location:34473
      AA-adenyl-dom; amino acid adenylation domain
      pfam00550
      Location:557628
      PP-binding; Phosphopantetheine attachment site
      pfam13360
      Location:7921012
      PQQ_2; PQQ-like domain
      cl11493
      Location:8441090
      PQQ_DH_like; PQQ-dependent dehydrogenases and related proteins
      cl17068
      Location:16532
      AFD_class_I; Adenylate forming domain, Class I superfamily

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

      Range
      76873659..76905519 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006534859.3XP_006534922.1  acyl-CoA synthetase family member 4 isoform X7

      Conserved Domains (4) summary
      COG1520
      Location:592800
      PQQ; Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis]
      pfam00550
      Location:395466
      PP-binding; Phosphopantetheine attachment site
      cl11493
      Location:622742
      PQQ_DH_like; PQQ-dependent dehydrogenases and related proteins
      cl17068
      Location:55370
      AFD_class_I; Adenylate forming domain, Class I superfamily
    2. XM_006534857.3XP_006534920.1  acyl-CoA synthetase family member 4 isoform X6

      Conserved Domains (4) summary
      pfam00550
      Location:395466
      PP-binding; Phosphopantetheine attachment site
      pfam13360
      Location:630850
      PQQ_2; PQQ-like domain
      cl11493
      Location:682928
      PQQ_DH_like; PQQ-dependent dehydrogenases and related proteins
      cl17068
      Location:55370
      AFD_class_I; Adenylate forming domain, Class I superfamily
    3. XM_006534854.2XP_006534917.1  acyl-CoA synthetase family member 4 isoform X2

      Conserved Domains (6) summary
      TIGR01733
      Location:34473
      AA-adenyl-dom; amino acid adenylation domain
      pfam00550
      Location:557628
      PP-binding; Phosphopantetheine attachment site
      pfam13360
      Location:7921013
      PQQ_2; PQQ-like domain
      sd00039
      Location:815849
      7WD40; WD40 repeat [structural motif]
      cl11493
      Location:7841046
      PQQ_DH_like; PQQ-dependent dehydrogenases and related proteins
      cl17068
      Location:16532
      AFD_class_I; Adenylate forming domain, Class I superfamily
    4. XM_017320841.1XP_017176330.1  acyl-CoA synthetase family member 4 isoform X3

    5. XM_011249423.2XP_011247725.1  acyl-CoA synthetase family member 4 isoform X4

      Conserved Domains (5) summary
      TIGR01733
      Location:34473
      AA-adenyl-dom; amino acid adenylation domain
      pfam00550
      Location:557628
      PP-binding; Phosphopantetheine attachment site
      sd00039
      Location:816850
      7WD40; WD40 repeat [structural motif]
      cl11493
      Location:784904
      PQQ_DH_like; PQQ-dependent dehydrogenases and related proteins
      cl17068
      Location:16532
      AFD_class_I; Adenylate forming domain, Class I superfamily
    6. XM_006534856.3XP_006534919.1  acyl-CoA synthetase family member 4 isoform X5

      Conserved Domains (5) summary
      TIGR01733
      Location:34473
      AA-adenyl-dom; amino acid adenylation domain
      pfam00550
      Location:557628
      PP-binding; Phosphopantetheine attachment site
      sd00039
      Location:816850
      7WD40; WD40 repeat [structural motif]
      cl11493
      Location:784904
      PQQ_DH_like; PQQ-dependent dehydrogenases and related proteins
      cl17068
      Location:16532
      AFD_class_I; Adenylate forming domain, Class I superfamily
    7. XM_006534853.2XP_006534916.1  acyl-CoA synthetase family member 4 isoform X1

      See identical proteins and their annotated locations for XP_006534916.1

      UniProtKB/Swiss-Prot
      Q80WC9
      Conserved Domains (5) summary
      TIGR01733
      Location:34473
      AA-adenyl-dom; amino acid adenylation domain
      pfam00550
      Location:557628
      PP-binding; Phosphopantetheine attachment site
      pfam13360
      Location:7921012
      PQQ_2; PQQ-like domain
      cl11493
      Location:8441090
      PQQ_DH_like; PQQ-dependent dehydrogenases and related proteins
      cl17068
      Location:16532
      AFD_class_I; Adenylate forming domain, Class I superfamily
    8. XM_011249422.1XP_011247724.1  acyl-CoA synthetase family member 4 isoform X1

      See identical proteins and their annotated locations for XP_011247724.1

      UniProtKB/Swiss-Prot
      Q80WC9
      Conserved Domains (5) summary
      TIGR01733
      Location:34473
      AA-adenyl-dom; amino acid adenylation domain
      pfam00550
      Location:557628
      PP-binding; Phosphopantetheine attachment site
      pfam13360
      Location:7921012
      PQQ_2; PQQ-like domain
      cl11493
      Location:8441090
      PQQ_DH_like; PQQ-dependent dehydrogenases and related proteins
      cl17068
      Location:16532
      AFD_class_I; Adenylate forming domain, Class I superfamily
    9. XM_011249421.1XP_011247723.1  acyl-CoA synthetase family member 4 isoform X1

      See identical proteins and their annotated locations for XP_011247723.1

      UniProtKB/Swiss-Prot
      Q80WC9
      Conserved Domains (5) summary
      TIGR01733
      Location:34473
      AA-adenyl-dom; amino acid adenylation domain
      pfam00550
      Location:557628
      PP-binding; Phosphopantetheine attachment site
      pfam13360
      Location:7921012
      PQQ_2; PQQ-like domain
      cl11493
      Location:8441090
      PQQ_DH_like; PQQ-dependent dehydrogenases and related proteins
      cl17068
      Location:16532
      AFD_class_I; Adenylate forming domain, Class I superfamily
    10. XM_006534860.3XP_006534923.1  acyl-CoA synthetase family member 4 isoform X8

      Conserved Domains (6) summary
      COG0365
      Location:13176
      Acs; Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase [Lipid transport and metabolism]
      pfam00550
      Location:195266
      PP-binding; Phosphopantetheine attachment site
      pfam13360
      Location:430650
      PQQ_2; PQQ-like domain
      sd00039
      Location:453487
      7WD40; WD40 repeat [structural motif]
      cl11493
      Location:482728
      PQQ_DH_like; PQQ-dependent dehydrogenases and related proteins
      cl17068
      Location:9170
      AFD_class_I; Adenylate forming domain, Class I superfamily

    RNA

    1. XR_001784674.1 RNA Sequence

    2. XR_389268.3 RNA Sequence

    3. XR_389266.3 RNA Sequence

    4. XR_001784675.1 RNA Sequence

    5. XR_880391.2 RNA Sequence

    6. XR_880390.2 RNA Sequence

    7. XR_001784673.1 RNA Sequence

      Related
      ENSMUST00000126741.7, OTTMUST00000065593
    8. XR_389267.2 RNA Sequence

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