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    Camkk1 calcium/calmodulin-dependent protein kinase kinase 1, alpha [ Mus musculus (house mouse) ]

    Gene ID: 55984, updated on 3-Apr-2018
    Official Symbol
    Camkk1provided by MGI
    Official Full Name
    calcium/calmodulin-dependent protein kinase kinase 1, alphaprovided by MGI
    Primary source
    MGI:MGI:1891766
    See related
    Ensembl:ENSMUSG00000020785 Vega:OTTMUSG00000006121
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Camkk; AI846603; CaMKKalpha
    Expression
    Broad expression in bladder adult (RPKM 25.3), cortex adult (RPKM 17.1) and 15 other tissues See more
    Orthologs
    Location:
    11; 11 B4
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (73015305..73042073)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (72832510..72855575)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene ATPase, Ca++ transporting, ubiquitous Neighboring gene RIKEN cDNA 4732414G09 gene Neighboring gene purinergic receptor P2X, ligand-gated ion channel, 1 Neighboring gene nuclear cap binding subunit 3 Neighboring gene integrin alpha E, epithelial-associated Neighboring gene histone H3 associated protein kinase

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    calmodulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    calmodulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    calmodulin-dependent protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    calmodulin-dependent protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    calmodulin-dependent protein kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    activation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    positive regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Preferred Names
    calcium/calmodulin-dependent protein kinase kinase 1
    Names
    caM-KK 1
    caM-KK alpha
    caM-kinase IV kinase
    caM-kinase kinase 1
    caM-kinase kinase alpha
    caMKK 1
    caMKK alpha
    calcium calmodulin dependent protein kinase kinase alpha
    NP_061371.2
    XP_006533823.1
    XP_006533824.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_018883.2NP_061371.2  calcium/calmodulin-dependent protein kinase kinase 1

      See identical proteins and their annotated locations for NP_061371.2

      Status: VALIDATED

      Source sequence(s)
      AI846603, AK144483
      Consensus CDS
      CCDS24993.1
      UniProtKB/Swiss-Prot
      Q8VBY2
      Related
      ENSMUSP00000090613.6, OTTMUSP00000006419, ENSMUST00000092937.12, OTTMUST00000013839
      Conserved Domains (2) summary
      smart00220
      Location:128409
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14200
      Location:127410
      STKc_CaMKK1; Catalytic domain of the Serine/Threonine kinase, Calmodulin Dependent Protein Kinase Kinase 1

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      73015305..73042073
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006533761.3XP_006533824.1  calcium/calmodulin-dependent protein kinase kinase 1 isoform X1

      See identical proteins and their annotated locations for XP_006533824.1

      UniProtKB/Swiss-Prot
      Q8VBY2
      Conserved Domains (2) summary
      smart00220
      Location:128409
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14200
      Location:127410
      STKc_CaMKK1; Catalytic domain of the Serine/Threonine kinase, Calmodulin Dependent Protein Kinase Kinase 1
    2. XM_006533760.3XP_006533823.1  calcium/calmodulin-dependent protein kinase kinase 1 isoform X1

      See identical proteins and their annotated locations for XP_006533823.1

      UniProtKB/Swiss-Prot
      Q8VBY2
      Conserved Domains (2) summary
      smart00220
      Location:128409
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14200
      Location:127410
      STKc_CaMKK1; Catalytic domain of the Serine/Threonine kinase, Calmodulin Dependent Protein Kinase Kinase 1

    Reference GRCm38.p4 NOD/MrkTac

    Genomic

    1. NT_166317.2 Reference GRCm38.p4 NOD/MrkTac

      Range
      110121..133186
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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