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    MYO1C myosin IC [ Homo sapiens (human) ]

    Gene ID: 4641, updated on 8-Nov-2017
    Official Symbol
    MYO1Cprovided by HGNC
    Official Full Name
    myosin ICprovided by HGNC
    Primary source
    HGNC:HGNC:7597
    See related
    Ensembl:ENSG00000197879 MIM:606538; Vega:OTTHUMG00000090323
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NMI; MMIb; myr2; MMI-beta
    Summary
    This gene encodes a member of the unconventional myosin protein family, which are actin-based molecular motors. The protein is found in the cytoplasm, and one isoform with a unique N-terminus is also found in the nucleus. The nuclear isoform associates with RNA polymerase I and II and functions in transcription initiation. The mouse ortholog of this protein also functions in intracellular vesicle transport to the plasma membrane. Multiple transcript variants encoding different isoforms have been found for this gene. The related gene myosin IE has been referred to as myosin IC in the literature, but it is a distinct locus on chromosome 19. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    17p13.3
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 17 NC_000017.11 (1464186..1492707, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (1367480..1396001, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon Neighboring gene CRK proto-oncogene, adaptor protein Neighboring gene uncharacterized LOC105371483 Neighboring gene inositol polyphosphate-5-phosphatase K Neighboring gene PITPNA antisense RNA 1 Neighboring gene phosphatidylinositol transfer protein alpha

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • B-WICH complex positively regulates rRNA expression, organism-specific biosystem (from REACTOME)
      B-WICH complex positively regulates rRNA expression, organism-specific biosystemThe B-WICH complex is a large 3 Mdalton complex containing SMARCA5 (SNF2H), BAZ1B (WSTF), ERCC6 (CSB), MYO1C (Nuclear myosin 1c) (Cavellan et al. 2006, Percipalle et al. 2006, Vintermist et al. 2001,...
    • Epigenetic regulation of gene expression, organism-specific biosystem (from REACTOME)
      Epigenetic regulation of gene expression, organism-specific biosystemEpigenetic processes regulate gene expression by modulating the frequency, rate, or extent of gene expression in a mitotically or meiotically heritable way that does not entail a change in the DNA se...
    • Fcgamma receptor (FCGR) dependent phagocytosis, organism-specific biosystem (from REACTOME)
      Fcgamma receptor (FCGR) dependent phagocytosis, organism-specific biosystemPhagocytosis is one of the important innate immune responses that function to eliminate invading infectious agents. Monocytes, macrophages, and neutrophils are the professional phagocytic cells. Phag...
    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Innate Immune System, organism-specific biosystem (from REACTOME)
      Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
    • Insulin Signaling, organism-specific biosystem (from WikiPathways)
      Insulin Signaling, organism-specific biosystemInsulin signaling influences energy metabolism as well as growth. The presence of insulin signals the fed state, and this signal is passed via the AKT branch, which leads to the uptake of glucose fro...
    • Membrane Trafficking, organism-specific biosystem (from REACTOME)
      Membrane Trafficking, organism-specific biosystemThe secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is ma...
    • Positive epigenetic regulation of rRNA expression, organism-specific biosystem (from REACTOME)
      Positive epigenetic regulation of rRNA expression, organism-specific biosystemTranscription of rRNA genes is controlled by epigenetic activation and repression (reviewed in Percipalle and Farrants 2006, McStay and Grummt 2008, Goodfellow and Zomerdijk 2012, Grummt and Langst 2...
    • Regulation of actin dynamics for phagocytic cup formation, organism-specific biosystem (from REACTOME)
      Regulation of actin dynamics for phagocytic cup formation, organism-specific biosystemThe actin cytoskeleton is fundamental for phagocytosis and members of the Rho family GTPases RAC and CDC42 are involved in actin cytoskeletal regulation leading to pseudopod extension. Active RAC and...
    • Translocation of GLUT4 to the plasma membrane, organism-specific biosystem (from REACTOME)
      Translocation of GLUT4 to the plasma membrane, organism-specific biosystemIn adipocytes and myocytes insulin signaling causes intracellular vesicles carrying the GLUT4 (SLC2A4) glucose transporter to translocate to the plasma membrane, allowing the cells to take up glucose...
    • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
      Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ23903

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    Ral GTPase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    actin filament binding IEA
    Inferred from Electronic Annotation
    more info
     
    actin-dependent ATPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    microfilament motor activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein C-terminus binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    basal plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    brush border IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    filamentous actin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane raft IDA
    Inferred from Direct Assay
    more info
    PubMed 
    microvillus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    myosin I complex IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear body IDA
    Inferred from Direct Assay
    more info
     
    nuclear pore IEA
    Inferred from Electronic Annotation
    more info
     
    nucleolus IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ruffle membrane IEA
    Inferred from Electronic Annotation
    more info
     
    stereocilium membrane IEA
    Inferred from Electronic Annotation
    more info
     
    NOT stress fiber IDA
    Inferred from Direct Assay
    more info
    PubMed 
    unconventional myosin complex TAS
    Traceable Author Statement
    more info
    PubMed 
    Preferred Names
    unconventional myosin-Ic
    Names
    myosin-I beta
    myosin-Ic
    nuclear myosin I

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_047063.1 RefSeqGene

      Range
      5001..33522
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001080779.1NP_001074248.1  unconventional myosin-Ic isoform a

      See identical proteins and their annotated locations for NP_001074248.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AI220881, BC068013, CA422782, CD050346, DB241937
      Consensus CDS
      CCDS42226.1
      UniProtKB/Swiss-Prot
      O00159
      Related
      ENSP00000352834.5, OTTHUMP00000115372, ENST00000359786.9, OTTHUMT00000206685
      Conserved Domains (4) summary
      smart00015
      Location:756776
      IQ; Calmodulin-binding motif
      smart00242
      Location:43731
      MYSc; Myosin. Large ATPases
      cd01378
      Location:62718
      MYSc_Myo1; class I myosin, motor domain
      pfam06017
      Location:8741041
      Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding
    2. NM_001080950.1NP_001074419.1  unconventional myosin-Ic isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and 5' CDS, compared to variant 1. The resulting isoform (b) has a shorter and unique N-terminus when compared to isoform a. This isoform is also known as nuclear myosin I.
      Source sequence(s)
      AI220881, BC068013, BP284965, CA422782, CN313279, DB241937
      Consensus CDS
      CCDS45562.1
      UniProtKB/Swiss-Prot
      O00159
      Related
      ENSP00000412197.2, OTTHUMP00000257611, ENST00000438665.6, OTTHUMT00000438826
      Conserved Domains (4) summary
      smart00015
      Location:737757
      IQ; Calmodulin-binding motif
      smart00242
      Location:24712
      MYSc; Myosin. Large ATPases
      cd01378
      Location:43699
      MYSc_Myo1; class I myosin, motor domain
      pfam06017
      Location:8551022
      Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding
    3. NM_033375.4NP_203693.3  unconventional myosin-Ic isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains a distinct 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. The resulting isoform (c) has a shorter N terminus when compared to isoform a.
      Source sequence(s)
      AI220881, BC068013, BP255642, CA422782, DB241937
      Consensus CDS
      CCDS11003.1
      UniProtKB/Swiss-Prot
      O00159
      Related
      ENSP00000354283.2, ENST00000361007.6
      Conserved Domains (4) summary
      smart00015
      Location:721741
      IQ; Calmodulin-binding motif
      smart00242
      Location:8696
      MYSc; Myosin. Large ATPases
      cd01378
      Location:27683
      MYSc_Myo1; class I myosin, motor domain
      pfam06017
      Location:8391006
      Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p7 Primary Assembly

      Range
      1464186..1492707 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018928.2 Alternate CHM1_1.1

      Range
      1376234..1404693 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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