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    DUSP1 dual specificity phosphatase 1 [ Homo sapiens (human) ]

    Gene ID: 1843, updated on 5-Feb-2017
    Official Symbol
    DUSP1provided by HGNC
    Official Full Name
    dual specificity phosphatase 1provided by HGNC
    Primary source
    HGNC:HGNC:3064
    See related
    Ensembl:ENSG00000120129 MIM:600714; Vega:OTTHUMG00000130523
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HVH1; MKP1; CL100; MKP-1; PTPN10
    Summary
    The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues. Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes. Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    5q35.1
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 5 NC_000005.10 (172768090..172771200, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (172195093..172198203, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene neuralized E3 ubiquitin protein ligase 1B Neighboring gene uncharacterized LOC107986479 Neighboring gene uncharacterized LOC101928093 Neighboring gene uncharacterized LOC105377730 Neighboring gene family with sequence similarity 58 member A pseudogene Neighboring gene endoplasmic reticulum-golgi intermediate compartment 1

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Meta-analysis of genome-wide association studies identifies novel loci that influence cupping and the glaucomatous process.
    NHGRI GWA Catalog

    Replication interactions

    Interaction Pubs
    Knockdown of dual specificity protein phosphatase 1 (DUSP1) by siRNAs significantly enhances HIV-1 replication in human acute monocytic leukemia cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Nef nef HIV-1 Nef inhibits TNF-alpha release and enhances the expression of MKP-1 in human macrophages PubMed
    Tat tat Primary human Muller glia cells treated with both HIV-1 clade B and clade C Tat upregulate the expression of MKP-1 PubMed
    Vif vif HIV-1 Vif upregulates the expression of dual specificity phosphatase 1 (DUSP1) in Vif-expression T cells PubMed
    Vpr vpr Treatment of human primary astrocytes with HIV-1 Vpr downregulates expression of eleven genes, BNIP3, CYGB, DUOX2, DUSP1, FOXM1, GAPDH, HPRT1, MT3, MTL5, PTGS2, and SCARA3 PubMed

    Go to the HIV-1, Human Interaction Database

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    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    MAP kinase tyrosine/serine/threonine phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    growth factor binding IEA
    Inferred from Electronic Annotation
    more info
     
    non-membrane spanning protein tyrosine phosphatase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein tyrosine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cellular response to hormone stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    endoderm formation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    inactivation of MAPK activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    mitotic cell cycle arrest ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of DNA biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of MAP kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of MAPK cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of meiotic cell cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    peptidyl-threonine dephosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    peptidyl-tyrosine dephosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    regulation of mitotic cell cycle spindle assembly checkpoint ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    response to cAMP IEA
    Inferred from Electronic Annotation
    more info
     
    response to calcium ion IEA
    Inferred from Electronic Annotation
    more info
     
    response to estradiol IEA
    Inferred from Electronic Annotation
    more info
     
    response to glucocorticoid IEA
    Inferred from Electronic Annotation
    more info
     
    response to hydrogen peroxide IEA
    Inferred from Electronic Annotation
    more info
     
    response to light stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    response to oxidative stress TAS
    Traceable Author Statement
    more info
    PubMed 
    response to retinoic acid IEA
    Inferred from Electronic Annotation
    more info
     
    response to testosterone IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    dual specificity protein phosphatase 1
    Names
    CL 100
    MAP kinase phosphatase 1
    dual specificity protein phosphatase hVH1
    mitogen-activated protein kinase phosphatase 1
    protein-tyrosine phosphatase CL100
    serine/threonine specific protein phosphatase
    NP_004408.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_004417.3NP_004408.1  dual specificity protein phosphatase 1

      See identical proteins and their annotated locations for NP_004408.1

      Status: REVIEWED

      Source sequence(s)
      AA843403, AC022217, AK300487, BC022463
      Consensus CDS
      CCDS4380.1
      UniProtKB/Swiss-Prot
      P28562
      UniProtKB/TrEMBL
      B4DU40
      Related
      ENSP00000239223, OTTHUMP00000216442, ENST00000239223, OTTHUMT00000252943
      Conserved Domains (3) summary
      COG2453
      Location:188313
      CDC14; Protein-tyrosine phosphatase [Signal transduction mechanisms]
      cd00127
      Location:173309
      DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
      cd01446
      Location:7136
      DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p7 Primary Assembly

      Range
      172768090..172771200 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018916.2 Alternate CHM1_1.1

      Range
      171627607..171630717 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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