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    Ptpn22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) [ Mus musculus (house mouse) ]

    Gene ID: 19260, updated on 25-May-2017
    Official Symbol
    Ptpn22provided by MGI
    Official Full Name
    protein tyrosine phosphatase, non-receptor type 22 (lymphoid)provided by MGI
    Primary source
    MGI:MGI:107170
    See related
    Ensembl:ENSMUSG00000027843 Vega:OTTMUSG00000022455
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PEP; Ptpn8; 70zpep
    Orthologs
    Location:
    3; 3 F2.2
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 3 NC_000069.6 (103856802..103912252)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (103664215..103716170)

    Chromosome 3 - NC_000069.6Genomic Context describing neighboring genes Neighboring gene adaptor-related protein complex AP-4, beta 1 Neighboring gene BCLl2-like 15 Neighboring gene rosbin, round spermatid basic protein 1 Neighboring gene putative homeodomain transcription factor 1, opposite strand Neighboring gene putative homeodomain transcription factor 1

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    SH3 domain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein tyrosine kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein tyrosine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    T cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    T cell receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    autophagy IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to muramyl dipeptide IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to muramyl dipeptide ISO
    Inferred from Sequence Orthology
    more info
     
    dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    lipopolysaccharide-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of JUN kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of T cell activation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of T cell activation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of T cell receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of interleukin-6 secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of interleukin-6 secretion ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of interleukin-8 secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of interleukin-8 secretion ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of p38MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of p38MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of tumor necrosis factor production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of tumor necrosis factor production ISO
    Inferred from Sequence Orthology
    more info
     
    phosphoanandamide dephosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of CD8-positive, alpha-beta T cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of ERK1 and ERK2 cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of defense response to virus by host IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of granzyme B production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of interferon-alpha secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of interferon-beta secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of interferon-gamma secretion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein K63-linked ubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein K63-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of toll-like receptor 3 signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of toll-like receptor 3 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of toll-like receptor 4 signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of toll-like receptor 4 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of toll-like receptor 7 signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of toll-like receptor 9 signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription factor import into nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of type I interferon production ISO
    Inferred from Sequence Orthology
    more info
     
    protein dephosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of NIK/NF-kappaB signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of NIK/NF-kappaB signaling ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of T cell receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    NOT regulation of antigen processing and presentation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of calcium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of leukocyte migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of natural killer cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    response to lipopolysaccharide ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasmic side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasmic side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    tyrosine-protein phosphatase non-receptor type 22
    Names
    PEST domain-enriched tyrosine phosphatase
    hematopoietic cell protein-tyrosine phosphatase 70Z-PEP
    protein tyrosine phosphatase, non-receptor type 8
    NP_033005.1
    XP_006501211.1
    XP_006501212.1
    XP_006501213.1
    XP_011238343.1
    XP_011238344.1
    XP_017174993.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008979.2NP_033005.1  tyrosine-protein phosphatase non-receptor type 22

      See identical proteins and their annotated locations for NP_033005.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes a protein.
      Source sequence(s)
      AI327325, BY092932, M90388
      Consensus CDS
      CCDS38577.1
      UniProtKB/Swiss-Prot
      P29352
      Related
      ENSMUSP00000029433.7, OTTMUSP00000025543, ENSMUST00000029433.8, OTTMUST00000053696
      Conserved Domains (2) summary
      smart00194
      Location:24288
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:56288
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

    RNA

    1. NR_104070.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate 5' exon structure and an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AI327325, AK153812
      Related
      ENSMUST00000146071.7, OTTMUST00000053697

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000069.6 Reference GRCm38.p4 C57BL/6J

      Range
      103856802..103912252
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006501148.3XP_006501211.1  tyrosine-protein phosphatase non-receptor type 22 isoform X1

      See identical proteins and their annotated locations for XP_006501211.1

      UniProtKB/Swiss-Prot
      P29352
      Conserved Domains (2) summary
      smart00194
      Location:24288
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:56288
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    2. XM_006501149.3XP_006501212.1  tyrosine-protein phosphatase non-receptor type 22 isoform X1

      See identical proteins and their annotated locations for XP_006501212.1

      UniProtKB/Swiss-Prot
      P29352
      Conserved Domains (2) summary
      smart00194
      Location:24288
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:56288
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    3. XM_011240041.2XP_011238343.1  tyrosine-protein phosphatase non-receptor type 22 isoform X1

      See identical proteins and their annotated locations for XP_011238343.1

      UniProtKB/Swiss-Prot
      P29352
      Conserved Domains (2) summary
      smart00194
      Location:24288
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:56288
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    4. XM_011240042.2XP_011238344.1  tyrosine-protein phosphatase non-receptor type 22 isoform X1

      See identical proteins and their annotated locations for XP_011238344.1

      UniProtKB/Swiss-Prot
      P29352
      Conserved Domains (2) summary
      smart00194
      Location:24288
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:56288
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    5. XM_006501150.2XP_006501213.1  tyrosine-protein phosphatase non-receptor type 22 isoform X1

      See identical proteins and their annotated locations for XP_006501213.1

      UniProtKB/Swiss-Prot
      P29352
      Conserved Domains (2) summary
      smart00194
      Location:24288
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:56288
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    6. XM_017319504.1XP_017174993.1  tyrosine-protein phosphatase non-receptor type 22 isoform X2

    RNA

    1. XR_375500.3 RNA Sequence

    Reference GRCm38.p4 NOD/MrkTac

    Genomic

    1. NT_166287.2 Reference GRCm38.p4 NOD/MrkTac

      Range
      269183..322224
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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